2024
Using clinical and genetic risk factors for risk prediction of 8 cancers in the UK Biobank
Hu J, Ye Y, Zhou G, Zhao H. Using clinical and genetic risk factors for risk prediction of 8 cancers in the UK Biobank. JNCI Cancer Spectrum 2024, 8: pkae008. PMID: 38366150, PMCID: PMC10919929, DOI: 10.1093/jncics/pkae008.Peer-Reviewed Original ResearchPolygenic risk scoresUK BiobankCancer riskClinical risk factorsRisk of breast cancerRisk factorsPolygenic risk score modelHigh risk of developing cancerRisk of developing cancerLate-onset patientsRisk predictionClinical variablesHigh-risk individualsCox proportional hazards modelsProportional hazards modelGenetic risk factorsBaseline traitsClinical risk modelRisk scoreEarly-onset patientsHazards modelLate-onset groupEarly-onset groupBreast cancerHigh risk
2019
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesHigh linkage disequilibrium regionLinkage disequilibrium regionWide association studyDisequilibrium regionBioinformatics analysisTranscriptomic profilesMillion Veteran ProgramChromosome 17Genetic risk factorsNew insightsUK Biobank dataReexperiencing of traumaStriatal medium spiny neuronsVeteran ProgramSignificant regionsCAMKVEuropean AmericansBiobank dataMedium spiny neuronsTCF4BiologyKANSL1African American cohort
2017
T45 Genetic Factor Common To Schizophrenia And Hiv Infection Is Associated With Risky Sexual Behavior
Wang Q, Polimanti R, Kranzler H, Farrer L, Zhao H, Gelernter J. T45 Genetic Factor Common To Schizophrenia And Hiv Infection Is Associated With Risky Sexual Behavior. European Neuropsychopharmacology 2017, 27: s460-s461. DOI: 10.1016/j.euroneuro.2016.09.533.Peer-Reviewed Original ResearchRisky sexual behaviorBody mass indexHIV infectionPolygenic risk scoresRisk scoreSexual behaviorHuman immunodeficiency virus (HIV) infectionSame effect directionImmunodeficiency virus infectionSZ-polygenic risk scoreGenetic risk factorsGenetic risk scoreSemi-Structured AssessmentMass indexRisk factorsEpidemiologic correlationsVirus infectionObservational studySynaptic transmissionHIVBipolar disorderNerve impulse transmissionSerious disorderDrug dependenceInfection