1993
Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon
Ballantyne G, Goldenring J, Fleming F, Rush S, Flint J, Fielding L, Binder H, Modlin I. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. American Journal Of Physiology 1993, 264: g848-g854. PMID: 8388641, DOI: 10.1152/ajpgi.1993.264.5.g848.Peer-Reviewed Original ResearchConceptsVIP-stimulated increasesPeptide YYNeuropeptide YPancreatic polypeptideRabbit distal colonDistal colonRabbit distal colonic mucosaBasal short-circuit currentTetrodotoxin-insensitive mechanismVasoactive intestinal polypeptideDistal colonic mucosaColonic secretionIntestinal polypeptideReceptor phenotypeColonic mucosaParacrine regulatorVIP stimulationUssing chambersTissue cAMPPotent inhibitionCl fluxCyclic monophosphateColonInhibitionStimulation
1989
Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport.
Binder H, McGlone F, Sandle G. Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport. The Journal Of Physiology 1989, 410: 425-441. PMID: 2795485, PMCID: PMC1190488, DOI: 10.1113/jphysiol.1989.sp017542.Peer-Reviewed Original ResearchConceptsRU 28362Rat distal colonDistal colonCorticosteroid hormonesChannel blocker tetraethylammonium chlorideEffects of aldosteroneCase of aldosteroneTypes of receptorsChannel blocker amilorideMineralocorticoid receptorEpithelial responseAldosteroneControl animalsGlucocorticoid receptorPattern of responseConventional microelectrodesCell membrane changesTetraethylammonium chlorideCorticosteroidsReceptorsSpironolactoneColonDexamethasoneHormonePotency
1986
Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.
Sandle G, Hayslett J, Binder H. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986, 27: 309. PMID: 3699552, PMCID: PMC1433405, DOI: 10.1136/gut.27.3.309.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisInactive ulcerative colitisUlcerative colitisControl subjectsPharmacological dosesIntravenous administrationNet sodiumAcute ulcerative colitisAnti-inflammatory actionEffects of glucocorticoidsNet sodium absorptionColonic sodiumRectal pdAcute increaseAcute effectsColitisHydrocortisone hemisuccinateNormal subjectsPatientsGlucocorticoid hormonesSodium absorptionNet electrolyteGlucocorticoidsSimilar increaseSimilar changes
1984
Apical membrane properties and amiloride binding kinetics of the human descending colon
Wills N, Alles W, Sandle G, Binder H. Apical membrane properties and amiloride binding kinetics of the human descending colon. American Journal Of Physiology 1984, 247: g749-g757. PMID: 6095681, DOI: 10.1152/ajpgi.1984.247.6.g749.Peer-Reviewed Original ResearchColonic potassium transport.
Foster E, Hayslett J, Binder H. Colonic potassium transport. Kroc Foundation Series 1984, 17: 47-63. PMID: 6096514.Peer-Reviewed Original Research
1982
Demonstration of net potassium absorption in mammalian colon
Hayslett J, Halevy J, Pace P, Binder H. Demonstration of net potassium absorption in mammalian colon. American Journal Of Physiology 1982, 242: g209-g214. PMID: 7065184, DOI: 10.1152/ajpgi.1982.242.3.g209.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveColonIntestinal AbsorptionMaleMembrane PotentialsPerfusionPotassiumRatsSodiumConceptsPotassium-deficient animalsNet potassium absorptionNet potassium secretionPlasma potassium levelsPotassium secretionNet potassium movementPotassium levelsPotassium-loaded animalsPotassium movementMammalian colonColon of controlLow-sodium solutionDistal colonPotassium absorptionSodium solutionControl animalsProximal segmentDistal lumensIntestinal transportNet secretionColonCarrier-mediated processSecretionAdditional studiesVivo studies