2006
Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch
Subramanya S, Ramakrishna BS, Binder HJ, Farthing MJ, Young GP. Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch. Journal Of Pediatric Gastroenterology And Nutrition 2006, 43: 568-575. PMID: 17130730, DOI: 10.1097/01.mpg.0000239998.43141.b2.Peer-Reviewed Original ResearchConceptsOsmolarity oral rehydration solutionGlucose-ORSOral rehydration solutionNet water absorptionRehydration solutionWhole-gut perfusionSmall bowel absorptionColonic fluid absorptionSeverity of diarrheaAmylase-resistant starchSteady-state perfusionEscherichia coli heat-stable enterotoxinColi heat-stable enterotoxinBowel perfusionBowel absorptionSevere diarrheaDifferent etiologiesHigher net absorptionSegmental perfusionWistar ratsHeat-stable enterotoxinClinical practiceNet secretionExperimental animalsPerfusion
1999
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan S, Ramakrishna BS, Binder H. Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids. Digestive Diseases And Sciences 1999, 44: 1924-1930. PMID: 10505736, DOI: 10.1023/a:1018871412748.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsNa absorptionNaCl absorptionControl normal mucosaNet Cl secretionRat distal colonSodium chloride absorptionPresence of SCFAEffect of butyrateElectroneutral NaCl absorptionVoltage-clamp conditionsFatty acidsDistal colonNormal mucosaRat colonAbsorptive pathwaysCl(-) secretionChloride absorptionColonCAMP elevationSCFAMucosaSecretagoguesAdenosine monophosphateSecretion