1995
Fluid absorption in isolated perfused colonic crypts.
Singh S, Binder H, Boron W, Geibel J. Fluid absorption in isolated perfused colonic crypts. Journal Of Clinical Investigation 1995, 96: 2373-2379. PMID: 7593625, PMCID: PMC185889, DOI: 10.1172/jci118294.Peer-Reviewed Original ResearchConceptsCrypt cellsNM vasoactive intestinal peptideFluid absorptionLarge intestinal functionColonic cryptsVasoactive intestinal peptideLamina propria cellsNet fluid secretionRat distal colonNet fluid absorptionDibutyryl cyclic AMPIntestinal peptideDistal colonIntestinal functionLamina propriaPathophysiological paradigmCrypt preparationMM acetylcholineBasal stateNeurohumoral agonistsFluid secretionCellular elementsEpithelial cellsIntestinal cryptsCrypts
1968
Acute Irradiation Proctitisi in Man Development of eosinophilic crypt abscesses
Gelfand M, Tepper M, Katz L, Binder H, Yesner R, Floch M. Acute Irradiation Proctitisi in Man Development of eosinophilic crypt abscesses. Gastroenterology 1968, 54: 401-411. PMID: 5643028, DOI: 10.1016/s0016-5085(68)80101-5.Peer-Reviewed Original ResearchConceptsCrypt abscessesTissue eosinophiliaMarked tissue eosinophiliaMucoid rectal dischargeProminent tissue eosinophiliaLoss of vascularityPelvic irradiationRectal dischargeAbnormal mucosaRectal mucosaLeukocytic infiltrationMalignant diseaseBiopsy specimensHistological abnormalitiesInjurious stimuliCrypt epitheliumLamina propriaRadiation therapyX-ray treatmentAbscessLuminal patternMucosaTherapyNicotinamide adenine dinucleotideHistochemical studies