1989
Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors.
Turnamian S, Binder H. Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors. Journal Of Clinical Investigation 1989, 84: 1924-1929. PMID: 2592566, PMCID: PMC304073, DOI: 10.1172/jci114380.Peer-Reviewed Original ResearchConceptsElectrogenic sodium absorptionReceptor-specific agonistsSodium absorptionAldosterone receptorsRU 28362Continuous infusionDistal colonGlucocorticoid receptorAmiloride-sensitive sodium absorptionColonic electrolyte transportEffects of aldosteroneRat distal colonPotassium transportActive sodiumPotassium secretionAldosteroneSustained increasePotassium absorptionAgonistsReceptorsElectrolyte transportGlucocorticoidsUnidirectional NaInfusionColonAldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitorEffects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport.
Binder H, McGlone F, Sandle G. Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport. The Journal Of Physiology 1989, 410: 425-441. PMID: 2795485, PMCID: PMC1190488, DOI: 10.1113/jphysiol.1989.sp017542.Peer-Reviewed Original ResearchConceptsRU 28362Rat distal colonDistal colonCorticosteroid hormonesChannel blocker tetraethylammonium chlorideEffects of aldosteroneCase of aldosteroneTypes of receptorsChannel blocker amilorideMineralocorticoid receptorEpithelial responseAldosteroneControl animalsGlucocorticoid receptorPattern of responseConventional microelectrodesCell membrane changesTetraethylammonium chlorideCorticosteroidsReceptorsSpironolactoneColonDexamethasoneHormonePotency
1987
Aldosterone increases the maximal turnover rate of the sodium pump
Halevy J, Boulpaep E, Binder H, Hayslett J. Aldosterone increases the maximal turnover rate of the sodium pump. Pflügers Archiv - European Journal Of Physiology 1987, 410: 476-480. PMID: 3432052, DOI: 10.1007/bf00586528.Peer-Reviewed Original ResearchConceptsSodium pumpSodium transportLow sodium dietEffects of aldosteroneAdministration of aldosteroneHigher plasma levelsIntact adrenal glandsRat distal colonEquivalent short-circuit currentAddition of nystatinH aldosteroneSodium dietAdrenal glandChronic conditionsPlasma levelsDistal colonAcute actionsAldosteroneUssing chambersHours of exposureChronic exposureSame time periodApical barrierSimilar changesMucosal solution
1985
Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat
Foster E, Jones W, Hayslett J, Binder H. Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat. Gastroenterology 1985, 88: 41-46. PMID: 3964771, DOI: 10.1016/s0016-5085(85)80130-x.Peer-Reviewed Original ResearchConceptsPotassium-enriched dietChronic potassium loadingNet potassium secretionAldosterone levelsDietary potassiumPotassium adaptationNet potassium transportPotassium secretionAldosterone-independent mechanismsBasal aldosterone levelsPotassium-loaded animalsRole of aldosteronePotassium loadingInfusion of aldosteroneDistal colonic mucosaEffects of aldosteroneIntact adrenal glandsNet potassium absorptionPotassium transportAdrenal glandDistal colonColonic mucosaIntact ratsAdrenalectomized animalsExperimental rats