2004
Three distinct mechanisms of HCO3− secretion in rat distal colon
Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3− secretion in rat distal colon. American Journal Of Physiology - Cell Physiology 2004, 287: c612-c621. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsColonic mucosaDistal colonRat distal colonic mucosaDistal colonic mucosaCl- channel blockerSCFA/Channel blockersSerosal layerCrypt cellsCFTR blockerMicroM DIDSApical membrane anion channelApical membraneSecretionDependent secretionColonLumen ClSecretory mechanismMammalian colonBlockersMucosaStat techniqueDIDS
1993
Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro
Hyun C, Binder H. Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. American Journal Of Physiology 1993, 265: g467-g473. PMID: 8214069, DOI: 10.1152/ajpgi.1993.265.3.g467.Peer-Reviewed Original ResearchConceptsEffect of LTD4Inflammatory bowel diseaseLeukotriene D4Specific LTD4 receptor antagonistLamina propria cellsMediators of inflammationLTD4 receptor antagonistRat distal colonRat colonic mucosaElectrogenic Cl- secretionLTD4 effectsVoltage-clamp conditionsBowel diseaseSerotonergic receptorsReceptor antagonistCyclooxygenase metabolitesDistal colonColonic mucosaCyclooxygenase inhibitorSerosal additionCotransport inhibitorMaximal responseCl(-) secretionLipoxygenase metabolitesArachidonic acidInhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon
Ballantyne G, Goldenring J, Fleming F, Rush S, Flint J, Fielding L, Binder H, Modlin I. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. American Journal Of Physiology 1993, 264: g848-g854. PMID: 8388641, DOI: 10.1152/ajpgi.1993.264.5.g848.Peer-Reviewed Original ResearchConceptsVIP-stimulated increasesPeptide YYNeuropeptide YPancreatic polypeptideRabbit distal colonDistal colonRabbit distal colonic mucosaBasal short-circuit currentTetrodotoxin-insensitive mechanismVasoactive intestinal polypeptideDistal colonic mucosaColonic secretionIntestinal polypeptideReceptor phenotypeColonic mucosaParacrine regulatorVIP stimulationUssing chambersTissue cAMPPotent inhibitionCl fluxCyclic monophosphateColonInhibitionStimulation
1991
Apical membrane localization of ouabain-sensitive K(+)-activated ATPase activities in rat distal colon
Del Castillo J, Rajendran V, Binder H. Apical membrane localization of ouabain-sensitive K(+)-activated ATPase activities in rat distal colon. American Journal Of Physiology 1991, 261: g1005-g1011. PMID: 1837421, DOI: 10.1152/ajpgi.1991.261.6.g1005.Peer-Reviewed Original ResearchConceptsRat distal colonOuabain-insensitive fractionDistal colonOuabain-sensitive fractionOuabain-insensitive componentHalf-maximal concentrationApical membraneATPase activityColonic mucosaProximal colonColonActivation curveAbsorptive processesAdenosinetriphosphatase activityApical membrane localizationBasolateral membraneHomogenatesN-ethylmaleimideMucosaActivityOmeprazole
1988
Electrolyte transport in distal colon of sodium-depleted rats: effect of sodium repletion
Turnamian S, Binder H. Electrolyte transport in distal colon of sodium-depleted rats: effect of sodium repletion. American Journal Of Physiology 1988, 255: g329-g338. PMID: 2844099, DOI: 10.1152/ajpgi.1988.255.3.g329.Peer-Reviewed Original ResearchConceptsElectrogenic sodium absorptionElectroneutral sodium chloride absorptionPlasma aldosterone levelsAldosterone levelsSodium chloride absorptionPotassium secretionSodium absorptionSodium repletionDistal colonChloride absorptionElevated plasma aldosterone levelsSodium depletion increasesDistal colonic mucosaSodium-depleted ratsElectroneutral sodium absorptionRat distal colonExcess aldosteroneVoltage-clamp conditionsDietary sodiumColonic mucosaNormal animalsUnidirectional 22NaATPase activityElectrolyte transportSecretion
1986
Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats
Halevy J, Budinger M, Hayslett J, Binder H. Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats. Gastroenterology 1986, 91: 1227-1233. PMID: 3758615, DOI: 10.1016/s0016-5085(86)80021-x.Peer-Reviewed Original ResearchConceptsElectroneutral sodium chloride absorptionElectrogenic sodium absorptionSodium chloride absorptionRole of aldosteroneSodium-depleted animalsSodium absorptionChloride absorptionAldosterone infusionDistal colonPotassium secretionAmiloride-sensitive sodium absorptionContinuous aldosterone infusionDietary sodium depletionDistal colonic mucosaElevated aldosterone levelsActive potassium secretionRat distal colonAddition of amilorideRegulation of sodiumVoltage-clamp conditionsAldosterone levelsTime-dependent mannerSodium depletionColonic mucosaAldosteroneDietary potassium modulates active potassium absorption and secretion in rat distal colon
Foster E, Sandle G, Hayslett J, Binder H. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. American Journal Of Physiology 1986, 251: g619-g626. PMID: 3022598, DOI: 10.1152/ajpgi.1986.251.5.g619.Peer-Reviewed Original ResearchConceptsNet potassium absorptionNet potassium secretionPotassium secretionDistal colonic mucosaPotassium-loaded ratsRat distal colonPotassium transportActive potassium absorptionDietary potassiumPotassium absorptionColonic mucosaDistal colonMucosal amilorideLarge intestinePotassium depletionBody storesActive potassium transportSecretionBathing solutionPotassium loadingGroupK fluxesMucosaColonControlSodium and chloride transport in the large intestine of potassium-loaded rats
Budinger M, Foster E, Hayslett J, Binder H. Sodium and chloride transport in the large intestine of potassium-loaded rats. American Journal Of Physiology 1986, 251: g249-g252. PMID: 2426972, DOI: 10.1152/ajpgi.1986.251.2.g249.Peer-Reviewed Original ResearchConceptsPotassium secretionSodium absorptionRat distal colonic mucosaElectroneutral sodium chloride absorptionPotassium loadingNa-K-ATPase activityElectrogenic sodium absorptionDistal colonic mucosaActive potassium secretionPotassium-loaded ratsNet sodium absorptionSodium chloride absorptionActive sodium transportVoltage-clamp conditionsDietary potassiumColonic functionColonic mucosaNet chloride fluxNet sodium fluxJNanetNet sodiumLarge intestineChloride fluxSodium transportIdentical increase
1985
Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat
Foster E, Jones W, Hayslett J, Binder H. Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat. Gastroenterology 1985, 88: 41-46. PMID: 3964771, DOI: 10.1016/s0016-5085(85)80130-x.Peer-Reviewed Original ResearchConceptsPotassium-enriched dietChronic potassium loadingNet potassium secretionAldosterone levelsDietary potassiumPotassium adaptationNet potassium transportPotassium secretionAldosterone-independent mechanismsBasal aldosterone levelsPotassium-loaded animalsRole of aldosteronePotassium loadingInfusion of aldosteroneDistal colonic mucosaEffects of aldosteroneIntact adrenal glandsNet potassium absorptionPotassium transportAdrenal glandDistal colonColonic mucosaIntact ratsAdrenalectomized animalsExperimental rats
1982
Mechanism of potassium adaptation
Hayslett J, Binder H. Mechanism of potassium adaptation. American Journal Of Physiology 1982, 243: f103-f112. PMID: 7051849, DOI: 10.1152/ajprenal.1982.243.2.f103.Peer-Reviewed Original ResearchConceptsPotassium secretionPotassium adaptationChronic renal insufficiencyNa-K-ATPase activityAdministration of glucocorticoidsPotassium loadingNa-K-ATPaseTransepithelial potential differenceRenal insufficiencyPotassium excretionColonic mucosaExcretory loadDietary potassium loadingDistal nephronLarge intestinePotassium homeostasisDietary loadingElevated levelsPotassium pumpBasolateral portionEpitheliumCellular changesDistal portionSecretionBasolateral cell membrane