2009
Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
Wagshul M, McAllister J, Rashid S, Li J, Egnor M, Walker M, Yu M, Smith S, Zhang G, Chen J, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Experimental Neurology 2009, 218: 33-40. PMID: 19348801, DOI: 10.1016/j.expneurol.2009.03.034.Peer-Reviewed Original ResearchConceptsVentricular dilationAqueductal flowVentricular volumeInjection of kaolinNew experimental modelCSF pulsatilityClinical presentationMild ventriculomegalyVentricular sizeBasal cisternsChronic elevationAbnormal pulsationsCerebral aqueductHydrocephalic animalsEffective treatmentAdult ratsIntact controlsNormal levelsHydrocephalusExperimental modelT MRIRatsMonth periodVentriculomegalyDilation
2007
Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays
Anschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays. Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDose-Response Relationship, RadiationMagnetic Resonance ImagingMaleRadiation Injuries, ExperimentalRadiosurgeryRatsRats, Inbred F344ConceptsT2 signalCentral nervous system diseaseHigh T2 signalNervous system diseasesTesla magnetic resonance imagingFocal brain lesionsMagnetic resonance imagingBrain lesionsRadiosurgical approachRat brainSystem diseasesStereotactic radiosurgeryHigh-dose irradiationFuture treatmentLow dosesLesionsResonance imagingLow T1Dose irradiationBrainTreatmentPrecise targetsX-ray
2005
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy
Ma Y, Hof P, Grant S, Blackband S, Bennett R, Slatest L, McGuigan M, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience 2005, 135: 1203-1215. PMID: 16165303, DOI: 10.1016/j.neuroscience.2005.07.014.Peer-Reviewed Original Research
2001
Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study
McDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study. NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtrophyBrainBrain IschemiaBrain MappingCerebral VentriclesDisease Models, AnimalHippocampusImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, Neurologic MutantsMicroscopyNeurodegenerative DiseasesProsencephalonConceptsApoE-deficient miceModels of neurodegenerationPostischemic dayBrain atrophyMouse modelNeurodegenerative diseasesDorsal hippocampal volumeBrain volume changesMin of ischemiaHigh signal intensity areaTransgenic mouse modelProgression of pathologyCorresponding time pointsSignal intensity areaMagnetic resonance imagingHigh-resolution MRIT1-weighted MR imagingC57 miceDorsal hippocampusHippocampal volumeClinical conditionsIschemiaMRI studiesPredetermined protocolCognitive declineProgress in high field MRI at the University of Florida
Beck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida. Magnetic Resonance Materials In Physics, Biology And Medicine 2001, 13: 152-157. PMID: 11755090, PMCID: PMC3363288, DOI: 10.1007/bf02678590.Peer-Reviewed Original Research
2000
In vivo magnetic resonance imaging of transgene expression
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E, Basilion J. In vivo magnetic resonance imaging of transgene expression. Nature Medicine 2000, 6: 351-354. PMID: 10700241, DOI: 10.1038/73219.Peer-Reviewed Original Research
1999
Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy
Benveniste H, Einstein G, Kim K, Hulette C, Johnson G. Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14079-14084. PMID: 10570201, PMCID: PMC24193, DOI: 10.1073/pnas.96.24.14079.Peer-Reviewed Original ResearchAgedAged, 80 and overAlzheimer DiseaseColoring AgentsHumansMagnetic Resonance ImagingMiddle AgedPlaque, AmyloidProtonsIn vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine
Benveniste H, Qui H, Hedlund L, Hüttemeier P, Steele S, Johnson G. In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine. Regional Anesthesia & Pain Medicine 1999, 24: 311-318. PMID: 10445769, DOI: 10.1016/s1098-7339(99)90104-9.Peer-Reviewed Original ResearchConceptsDiffusion-weighted magnetic resonance microscopyRat spinal cordSpinal cordHyperbaric 5Hyperbaric lidocaineNeurologic deficitsGroup 2Group 1White matterGray matterIrreversible neurologic deficitsPersistent neurologic deficitsSpinal cord ischemiaContinuous spinal anesthesiaPresence of ischemiaBlood-nerve barrierEffects of ischemiaWhite matter tractsCord ischemiaIntrathecal anesthesiaIntrathecal lidocaineSpinal anesthesiaSpinal catheterPathophysiologic mechanismsCardiac arrest
1998
Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson A. Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. DOI: 10.1097/00115550-199823060-00014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF ratsSpinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson G. Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. PMID: 9840856, DOI: 10.1016/s1098-7339(98)90087-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF rats
1997
Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study
Qiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study. Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain IschemiaFemaleImage Processing, Computer-AssistedMagnetic Resonance ImagingPyridazinesQuinolinesRatsRats, Inbred F344Receptors, GlycineTime FactorsConceptsMiddle cerebral arteryStroke volumeIpsilateral common carotid arteryReduced stroke volumeFocal ischemic lesionsCommon carotid arteryGlycine/NMDA antagonistsMCA occlusionCerebral arteryIschemic lesionsMultiple time pointsNMDA antagonistsCarotid arteryDrug treatmentRat brainGroup 2Group 1Control groupVivo studiesTime pointsZD9379ArteryOcclusionHoursTreatment
1996
A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy
Hall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy. NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain IschemiaDisease Models, AnimalFemaleMagnetic Resonance ImagingMicroscopyModels, NeurologicalRatsRats, Inbred F344Stroke Volume
1993
Histology by magnetic resonance microscopy.
Johnson G, Benveniste H, Black R, Hedlund L, Maronpot R, Smith B. Histology by magnetic resonance microscopy. Magnetic Resonance Quarterly 1993, 9: 1-30. PMID: 8512830.Peer-Reviewed Original Research
1992
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBrainBrain IschemiaDiffusionFemaleGlutamatesGlutamic AcidMagnetic Resonance ImagingN-MethylaspartateOuabainRatsRats, Inbred StrainsStaining and LabelingConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1991
MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow
Maki J, Benveniste H, Macfall J, Piantadosi C, Johnson G. MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow. Journal Of Magnetic Resonance Imaging 1991, 1: 673-681. PMID: 1823172, DOI: 10.1002/jmri.1880010609.Peer-Reviewed Original ResearchConceptsCerebral blood flowRat cerebral blood flowBlood flowArterial carbon dioxide pressureLaser Doppler flowmetry studyMR imaging studiesMagnetic resonance imaging techniquesRat brainLDF valuesCarbon dioxide pressureImaging studiesMR imagingTissue microcirculationImaging valuesPaCO2MicrocirculationQualitative pictureMotion sensitivityPresent studyCarbon dioxide-induced changeImaging techniquesFC techniqueRat motionsGradient coilsImagingDiffusion/microcirculation MRI in the rat brain
Macfall J, Maki J, Johnson G, Hedlund L, Benveniste H, Copher G. Diffusion/microcirculation MRI in the rat brain. Magnetic Resonance In Medicine 1991, 19: 305-310. PMID: 1908936, DOI: 10.1002/mrm.1910190219.Peer-Reviewed Original ResearchQuantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain IschemiaCerebral InfarctionDiagnosis, Computer-AssistedMagnetic Resonance ImagingNecrosisRatsRats, Inbred StrainsSilverConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid arteryMaximization of contrast‐to‐noise ratio to distinguish diffusion and microcirculatory flow
Maki J, Benveniste H, MacFall J, Johnson G. Maximization of contrast‐to‐noise ratio to distinguish diffusion and microcirculatory flow. Journal Of Magnetic Resonance Imaging 1991, 1: 39-46. PMID: 1802129, DOI: 10.1002/jmri.1880010105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral InfarctionDiffusionIn Vitro TechniquesMagnetic Resonance ImagingMicrocirculationModels, StructuralRats