1993
Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolism
1991
Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose
Hilgier W, Benveniste H, Diemer N, Albrecht J. Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose. Acta Neurologica Scandinavica 1991, 83: 353-355. PMID: 1887755, DOI: 10.1111/j.1600-0404.1991.tb03961.x.Peer-Reviewed Original ResearchConceptsBrain regionsLocal cerebral metabolic rateCerebral metabolic rateDiscrete brain regionsHepatic encephalopathyParticular brain regionsCerebral cortexGlutamatergic neuronsGlutamatergic neurotransmissionMedulla oblongataAuditory cortexGlucose utilizationDeoxyglucose uptakeBioenergetic failureEnergy metabolismRatsCortexPossible linkMetabolic ratePossible contributionThioacetamideOblongataEncephalopathyHippocampusStriatumThe excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique