1985
Lung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbuminAccumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs
Jacobs H, Jobe A, Ikegami M, Jones S. Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs. Experimental Lung Research 1985, 8: 125-140. PMID: 3839748, DOI: 10.3109/01902148509057517.Peer-Reviewed Original ResearchConceptsAlveolar washTreatment doseAlveolar surfactantMean gestational ageArterial blood gasPeak inspiratory pressureMin of ageSurfactant pool sizeAlveolar surfactant accumulationPhosphatidylcholine specific activityCesarean sectionPremature lambsGestational agePremature lungInspiratory pressureIntratracheal administrationBlood gasTrace doseDilution techniqueDoseAgeAirwayPool sizeBirthAccumulation of surfactant
1984
A protein from airways of premature lambs that inhibits surfactant function
Ikegami M, Jobe A, Jacobs H, Lam R. A protein from airways of premature lambs that inhibits surfactant function. Journal Of Applied Physiology 1984, 57: 1134-1142. PMID: 6209255, DOI: 10.1152/jappl.1984.57.4.1134.Peer-Reviewed Original ResearchLack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age.
Jobe A, Jacobs H, Ikegami M. Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age. Journal Of Developmental Physiology 1984, 6: 417-21. PMID: 6568247.Peer-Reviewed Original ResearchConceptsFetal lung fluidPeak inspiratory pressureDays gestational ageLung diseaseLung fluidPremature lambsGestational ageInspiratory pressureConcentration of phosphatidylcholinePhosphatidylcholine concentrationNarrow gestational age rangePhosphatidylcholine pool sizesGestational age rangeTime of deliveryLung compliance valuesMechanical ventilationAlveolar washTotal phosphatidylcholineDiseaseAge rangeSeverityLack of correlationAgeLambsCompliance valuesSurfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant.
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal Of Clinical Investigation 1984, 73: 848-856. PMID: 6546766, PMCID: PMC425089, DOI: 10.1172/jci111280.Peer-Reviewed Original ResearchConceptsPieces of lungBlood flow distributionPulmonary blood flow distributionLungs of lambsMechanical ventilationRight ductal shuntPulmonary blood flowConstant distending pressurePeriod of ventilationGroups of lambsDuctal shuntPremature lambsAtelectatic areasSurfactant instillationVentricular outputTracheal instillationDistending pressureBlood flowLungLung piecesVentilationInstillationBirthLambsNatural surfactant
1983
Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs
Jobe A, Jacobs H, Ikegami M, Jones S. Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs. Pediatric Research 1983, 17: 444-448. PMID: 6553821, DOI: 10.1203/00006450-198306000-00002.Peer-Reviewed Original ResearchConceptsSurfactant instillationPremature lambsOnly ventilator settingPulmonary artery pressureDays gestational ageSurfactant treatmentArtery pressureCesarean sectionRespiratory supportCardiovascular effectsLung functionGestational ageCardiovascular statusInspiratory pressureRespiratory statusTransient deteriorationCardiac outputAortic pressureTracheal instillationVentilator settingsInfant ventilatorRegional bloodHeart rateInstillationBody weightSurfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 751-5. PMID: 6552894, DOI: 10.1164/arrd.1983.127.6.751.Peer-Reviewed Original ResearchConceptsLung diseaseAlveolar washCompliant lungsMinimal surface tensionLow minimal surface tensionRespiratory distress syndromePeak inspiratory pressurePhosphatidylcholine pool sizesDays gestational ageSurfactant pool sizePremature lambsDistress syndromeGestational ageInspiratory pressureLung tissueRespiratory diseaseTidal volumeLung slicesSurfactant phosphatidylcholineTotal phosphatidylcholineDiseaseSeverityPool sizeRate of incorporationLungLeft ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant. Circulation 1983, 67: 837-843. PMID: 6687448, DOI: 10.1161/01.cir.67.4.837.Peer-Reviewed Original ResearchConceptsPatent ductus arteriosusSystemic blood flowBlood flowVentricular performanceLV end-diastolic pressureEarly pathologic manifestationsOvert LV dysfunctionRight PDA shuntEnd-diastolic pressureHours of lifeLeft ventricular performanceRadionuclide-labeled microspheresDuctus arteriosus occlusionRegional blood flowPDA shuntLV dysfunctionPremature lambsRight shuntDuctus arteriosusEjection fractionPreterm lambsHemodynamic consequencesCardiac outputLeft ventriculographyPathologic manifestations
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements
1981
Sequential treatments of premature lambs with an artificial surfactant and natural surfactant.
Ikegami M, Jobe A, Jacobs H, Jones S. Sequential treatments of premature lambs with an artificial surfactant and natural surfactant. Journal Of Clinical Investigation 1981, 68: 491-496. PMID: 6790576, PMCID: PMC370823, DOI: 10.1172/jci110280.Peer-Reviewed Original ResearchConceptsArtificial surfactantPremature lambsGestational age lambsFetal lung fluidPO2 valuesGroups of lambsPressure-volume characteristicsMinimum surface tensionPremature lungAirway samplesNatural surfactant lipidAge lambsUntreated lambsMean pO2 valuesMinimal surface tensionLung fluidSurfactant lipidsSequential treatmentTreatmentNatural surfactantLambsHgPCO2 valuesAirwayLung