2014
ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data
Li J, Li X, Wang Q, Hu S, Wang Y, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, Group F. ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data. The Lancet 2014, 385: 441-451. PMID: 24969506, PMCID: PMC4415374, DOI: 10.1016/s0140-6736(14)60921-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAspirinChinaClopidogrelFemaleFibrinolytic AgentsHealthcare DisparitiesHospital MortalityHospitals, RuralHospitals, UrbanHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPatient AdmissionPercutaneous Coronary InterventionQuality of Health CareRetrospective StudiesTiclopidineTreatment OutcomeConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital mortalityHospital admissionMyocardial infarctionRetrospective analysisPrimary percutaneous coronary interventionAcute myocardial infarction admissionsProportion of patientsUse of aspirinPercutaneous coronary interventionMyocardial infarction admissionsTwo-stage random sampling designQuality of careAnalysis of treatmentBaseline characteristicsCardiac eventsHospital outcomesHospital stayCoronary interventionFamily Planning CommissionClinical profileHospital recordsMedian lengthSTEMI admissions
2008
Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use
Daugherty SL, Ho PM, Spertus JA, Jones PG, Bach RG, Krumholz HM, Peterson ED, Rumsfeld JS, Masoudi FA. Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use. JAMA Internal Medicine 2008, 168: 485-491. PMID: 18332293, DOI: 10.1001/archinte.168.5.485.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinContinuity of Patient CareEvidence-Based MedicineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProportional Hazards ModelsProspective StudiesRegistriesRegression AnalysisTreatment OutcomeConceptsAcute myocardial infarctionMedication useMyocardial infarctionMultivariable analysisEarly outpatientEvidence-based medication useProspective Registry Evaluating OutcomesSecondary analysisEarly Follow-upBeta-blocker useUse of aspirinCurrent guideline recommendationsPrimary care physiciansEvidence-based therapiesHigh rateEligible patientsStatin useClinical characteristicsHospital dischargePrimary outcomeCare physiciansGuideline recommendationsMedication prescriptionsFollow-upEvaluating Outcomes
2006
Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction
Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ, Krumholz HM, Rumsfeld JS. Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction. JAMA Internal Medicine 2006, 166: 1842-1847. PMID: 17000940, DOI: 10.1001/archinte.166.17.1842.Peer-Reviewed Original ResearchConceptsTherapy discontinuationMyocardial infarctionEvidence-based medicationsMulticenter prospective cohortUse of aspirinMultivariable survival analysisTransitions of careDiscontinuation of useProspective registryMortality benefitProspective cohortMultivariable analysisOutpatient settingMI hospitalizationDiscontinuationMortality riskMedicationsPatientsSurvival analysisHigh mortalityMortalityTreatment factorsMonthsInfarctionAspirinPhysician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction
Chen J, Rathore SS, Wang Y, Radford MJ, Krumholz HM. Physician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction. Journal Of General Internal Medicine 2006, 21: 238-244. PMID: 16637823, PMCID: PMC1828098, DOI: 10.1111/j.1525-1497.2006.00326.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionBoard-certified physiciansPhysician board certificationMyocardial infarctionFamily practitionersInternal medicineBoard certificationHigher useUse of aspirinQuality of careMultivariate regression analysisBoard-certified internistsElderly patientsHospitalized patientsClinical guidelinesMedicare patientsAspirinPatientsMortalityPhysiciansFamily practiceCareInfarctionRegression analysisCardiologists
2005
Aspirin Use in Older Patients With Heart Failure and Coronary Artery Disease National Prescription Patterns and Relationship With Outcomes
Masoudi FA, Wolfe P, Havranek EP, Rathore SS, Foody JM, Krumholz HM. Aspirin Use in Older Patients With Heart Failure and Coronary Artery Disease National Prescription Patterns and Relationship With Outcomes. Journal Of The American College Of Cardiology 2005, 46: 955-962. PMID: 16168275, DOI: 10.1016/j.jacc.2004.07.062.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHeart failureAspirin prescriptionAspirin useRenal insufficiencyLower riskLower unadjusted ratesNational prescription patternsUse of aspirinClustering of patientsEvidence of harmCause readmissionCoronary eventsOlder patientsPrescription patternsSecondary preventionArtery diseaseACE inhibitorsMultivariable analysisUnadjusted ratesHospital characteristicsTreatment benefitMedicare beneficiariesAspirinPatientsSex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002
Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM. Sex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002. New England Journal Of Medicine 2005, 353: 671-682. PMID: 16107620, PMCID: PMC2805130, DOI: 10.1056/nejmsa032214.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAspirinBlack PeopleCoronary AngiographyFemaleHealth Services AccessibilityHospital MortalityHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPlatelet Aggregation InhibitorsProcess Assessment, Health CareQuality of Health CareRisk FactorsSex FactorsUnited StatesWhite PeopleConceptsUse of aspirinMyocardial infarctionReperfusion therapyCoronary angiographyRacial differencesTreatment of patientsHospital deathHospital mortalityMultivariable adjustmentUnadjusted analysesNational registryInfarctionWhite womenAspirinAngiographyTherapyWhite menSexPatientsBlack womenSex differencesParticular treatmentBlack menWomenDeath
2004
Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction
Rathore SS, Masoudi FA, Havranek EP, Krumholz HM. Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction. The American Journal Of Medicine 2004, 117: 811-822. PMID: 15589484, PMCID: PMC2790535, DOI: 10.1016/j.amjmed.2004.06.034.Peer-Reviewed Original ResearchConceptsBeta-blocker useMyocardial infarctionWhite patientsCoronary revascularizationBlack patientsRacial differencesCardiac catheterization useLower crude ratesUse of aspirinDay of admissionHealth care useTreatment of patientsAcute myocardial infarctionService Medicare beneficiariesMedical record dataQuality of careElderly feeRevascularization useAspirin useMultivariable adjustmentElderly patientsCardiac catheterizationCardiac proceduresCare useCrude rate
2003
Effects of age on the quality of care provided to older patients with acute myocardial infarction
Rathore SS, Mehta RH, Wang Y, Radford MJ, Krumholz HM. Effects of age on the quality of care provided to older patients with acute myocardial infarction. The American Journal Of Medicine 2003, 114: 307-315. PMID: 12681459, DOI: 10.1016/s0002-9343(02)01531-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAttitude of Health PersonnelCohort StudiesCombined Modality TherapyCoronary Care UnitsCritical CareDrug UtilizationFemaleGuideline AdherenceHealth Services AccessibilityHealth Services for the AgedHumansLogistic ModelsMaleMedicareMyocardial InfarctionOdds RatioPractice Patterns, Physicians'Quality of Health CareRisk AssessmentSurvival AnalysisThrombolytic TherapyUnited StatesConceptsAcute reperfusion therapyAcute myocardial infarctionMyocardial infarctionReperfusion therapyEffect of ageElderly patientsOlder patientsAge-associated variationsGuideline-recommended medical therapyAngiotensin-converting enzyme inhibitorGuideline-indicated therapiesPrescription of aspirinUse of aspirinCooperative Cardiovascular ProjectUse of therapiesQuality of careAcute reperfusionTreatment contraindicationsMedical therapyComorbid conditionsACE inhibitorsMedicare patientsHospital effectsPatientsEnzyme inhibitors
2001
Quality of care among elderly patients hospitalized with unstable angina
Shahi C, Rathore S, Wang Y, Thakur R, Wu W, Lewis J, Petrillo M, Radford M, Krumholz H. Quality of care among elderly patients hospitalized with unstable angina. American Heart Journal 2001, 142: 263-270. PMID: 11479465, DOI: 10.1067/mhj.2001.116477.Peer-Reviewed Original ResearchConceptsQuality of careMinutes of admissionUnstable anginaHealth care policyElderly patientsTherapeutic anticoagulationIntravenous heparinElectrocardiographic examinationCare policyPrescription of aspirinUse of aspirinHalf of patientsEligible patientsRisk stratificationConnecticut hospitalsElderly MedicareAnginaPatientsTherapeutic contraindicationsTherapeutic interventionsAspirinAdmissionHospitalCareAnticoagulationAspirin and the Treatment of Heart Failure in the Elderly
Krumholz HM, Chen YT, Radford MJ. Aspirin and the Treatment of Heart Failure in the Elderly. JAMA Internal Medicine 2001, 161: 577-582. PMID: 11252118, DOI: 10.1001/archinte.161.4.577.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHeart failureArtery diseaseBenefits of aspirinPatients 65 yearsRetrospective cohort studyUse of aspirinGroup of patientsAspirin prescriptionAspirin therapyCohort studyDischarge medicationsOlder patientsPatient characteristicsRandomized trialsVascular diseaseTreatment characteristicsConnecticut hospitalsBaseline differencesAspirinPatientsLower mortalityStrong associationDiseaseStudy sample
1999
Performance of the '100 top hospitals': what does the report card report?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Performance of the '100 top hospitals': what does the report card report? Health Affairs 1999, 18: 53-68. PMID: 10425843, DOI: 10.1377/hlthaff.18.4.53.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionElderly AMI patientsThirty-day mortalityUse of aspirinLower readmission ratesHospital peer groupsTop hospitalsReadmission ratesAMI patientsSuperior clinical performanceHospital studyMyocardial infarctionHospital costsMedicare patientsBetter outcomesHospitalBetter carePatientsClinical performanceLower lengthReperfusionInfarctionAspirinStayMortalityDo “America's Best Hospitals” Perform Better for Acute Myocardial Infarction?
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction? New England Journal Of Medicine 1999, 340: 286-292. PMID: 9920954, DOI: 10.1056/nejm199901283400407.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinFemaleHealth Care SurveysHospitalsHumansLogistic ModelsMaleMedicareMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CareQuality of Health CareSeverity of Illness IndexThrombolytic TherapyUnited StatesConceptsAcute myocardial infarctionShort-term mortalityMyocardial infarctionAmerica's Best HospitalsBest HospitalsSurvival advantageLower short-term mortalityBeta-blocker therapyRates of therapyHigh rateOutcomes of patientsUse of aspirinCooperative Cardiovascular ProjectElderly Medicare beneficiariesType of hospitalQuality of hospitalsReperfusion therapyElderly patientsRate of useBypass surgeryCardiac catheterizationCoronary angioplastyMedicare beneficiariesInfarctionAspirin
1998
Trends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina
Krumholz H, Philbin D, Wang Y, Vaccarino V, Murillo J, Therrien M, Williams J, Radford M. Trends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina. Journal Of The American College Of Cardiology 1998, 31: 957-963. PMID: 9561993, DOI: 10.1016/s0735-1097(98)00106-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngina, UnstableAnticoagulantsAspirinConnecticutFemaleGuideline AdherenceHeparinHospitalsHumansMaleMedicarePlatelet Aggregation InhibitorsPractice Guidelines as TopicQuality Indicators, Health CareQuality of Health CareRetrospective StudiesSurvival AnalysisUnited StatesConceptsUse of aspirinUnstable anginaElderly patientsConsecutive patientsHospital admissionRetrospective cohort studyPrincipal discharge diagnosisPatterns of treatmentCare of patientsGuideline-based useQuality of careHealth care policyAHCPR guidelinesChest painHospital dischargeCohort studyMedical chartsPatient factorsDischarge diagnosisPatient outcomesPractice patternsConnecticut hospitalsPractice guidelinesAnginaMedicare beneficiaries
1996
Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes.
Krumholz HM, Radford MJ, Ellerbeck EF, Hennen J, Meehan TP, Petrillo M, Wang Y, Jencks SF. Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes. Annals Of Internal Medicine 1996, 124: 292-8. PMID: 8554223, DOI: 10.7326/0003-4819-124-3-199602010-00002.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrescription of aspirinMyocardial infarctionPatient characteristicsPrescribed useMortality rate 6 monthsBetter overall health statusRate 6 monthsBeta-blocker therapyPatients 65 yearsUse of aspirinPatient demographic characteristicsAcute care hospitalsOverall health statusPrescribed aspirinDischarge medicationsElderly patientsHospital dischargeSecondary preventionCare hospitalClinical factorsMedical chartsMultivariable analysisCardiac proceduresTreatment characteristics
1995
Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes.
Krumholz H, Radford M, Ellerbeck E, Hennen J, Meehan T, Petrillo M, Wang Y, Kresowik T, Jencks S. Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes. Circulation 1995, 92: 2841-7. PMID: 7586250, DOI: 10.1161/01.cir.92.10.2841.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUse of aspirinDays of hospitalizationElderly patientsMyocardial infarctionMedicare beneficiariesHospital medical recordsElderly Medicare beneficiariesHigh-risk characteristicsPopulation-based sampleDelivery of careQuality of careAspirin therapyMore comorbiditiesAspirin useChest painAbsolute contraindicationHeart failureThrombolytic therapyPotential confoundersMedical recordsSafe treatmentEffective therapyHigh riskLower odds