2024
Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress
da Cunha Menezes E, de Abreu F, Davis J, Maurer S, Roshko V, Richardson A, Dowell J, Cassella S, Stevens H. Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Developmental Biology 2024, 515: 112-120. PMID: 39048051, PMCID: PMC11330572, DOI: 10.1016/j.ydbio.2024.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell MovementFemaleGABAergic NeuronsGene Expression Regulation, DevelopmentalGlutamate DecarboxylaseGlutathione PeroxidaseGlutathione Peroxidase GPX1HypothyroidismMaleMethimazoleMiceNF-E2-Related Factor 2Oxidative StressPlacentaPregnancyPrenatal Exposure Delayed EffectsThyroid HormonesConceptsGestational hypothyroidismGABAergic system developmentMaternal thyroid hormone supplyThyroid hormone supplyCortical GABAergic interneuronsMaternal thyroid hormonesGene expressionCD-1 miceCentral nervous system developmentEmbryonic day 9Central nervous systemIntrauterine restrictionGABAergic interneuronsGABAergic systemGPx1 gene expressionBrain gene expressionMouse brain developmentCD-1HypothyroidismEmbryonic dayNervous system developmentThyroid hormonesRisk factorsNeural system developmentHormonal imbalance
2012
Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex
Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology 2012, 38: 509-521. PMID: 22910687, PMCID: PMC3532962, DOI: 10.1016/j.psyneuen.2012.07.011.Peer-Reviewed Original Research
2010
Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits. Journal Of Neuroscience 2010, 30: 5590-5602. PMID: 20410112, PMCID: PMC2868832, DOI: 10.1523/jneurosci.5837-09.2010.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCerebral cortexFibroblast growth factor receptorCKO miceExcitatory neuronsPrefrontal cortexCortical neuron developmentEntire cerebral cortexRadial glial cellsSpecific fibroblast growth factor receptorsGrowth factor receptorGABAergic neuronsLimbic circuitsCortical neuronsGlial cellsSubcortical stationsBed nucleusCortical developmentLimbic systemStria terminalisSynaptic terminalsSecondary decreaseNeuronal precursorsVentricular zoneNeuron development