Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome
Bullert A, Wang H, Linahon M, Chimenti M, Adamcakova-Dodd A, Li X, Dailey M, Klingelhutz A, Ankrum J, Stevens H, Thorne P, Lehmler H. Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome. Toxicology 2024, 509: 153965. PMID: 39369937, DOI: 10.1016/j.tox.2024.153965.Peer-Reviewed Original ResearchBehavior compared to controlsImpact locomotor activityFemale ratsPCB52 exposureNose-only inhalationWorking memoryBrains of femalesBehavioral effectsLocomotor activityMale Sprague-Dawley ratsMale ratsRat brainStriatumNeurobehavioral testsBrain transcriptomeCerebellar cortexSprague-Dawley ratsBrainConsecutive daysNo significant differenceImmunohistochemical evaluationRatsChromatography-tandem mass spectrometryTotal cellsSignificant differenceCorrelation of telomere length in brain tissue with peripheral tissues in living human subjects
Carver A, Hing B, Elser B, Lussier S, Yamanashi T, Howard M, Kawasaki H, Shinozaki G, Stevens H. Correlation of telomere length in brain tissue with peripheral tissues in living human subjects. Frontiers In Molecular Neuroscience 2024, 17: 1303974. PMID: 38516039, PMCID: PMC10954899, DOI: 10.3389/fnmol.2024.1303974.Peer-Reviewed Original ResearchCorrelation of telomere lengthPeripheral tissuesTissue telomere lengthTelomere lengthDisorder pathophysiologyAssessed telomere lengthBuccal telomere lengthBrain disordersHuman brainBrainIntractable epilepsyLiving human subjectsBrain samplesAverage telomere lengthTime pointsTissue samplesBrain tissueChromosome stabilityTissueHuman subjectsSalivaLiving subjectsSubjects