Featured Publications
Functional connectome-wide associations of schizophrenia polygenic risk
Cao H, Zhou H, Cannon TD. Functional connectome-wide associations of schizophrenia polygenic risk. Molecular Psychiatry 2020, 26: 2553-2561. PMID: 32127647, PMCID: PMC9557214, DOI: 10.1038/s41380-020-0699-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainConnectomeHumansMagnetic Resonance ImagingNerve NetPsychotic DisordersSchizophreniaConceptsSchizophrenia polygenic riskLarge-scale brain networksGeneral cognitive abilityDefault mode systemHigher schizophrenia polygenic risk scoresIndividual's genetic liabilityHuman Connectome ProjectLower functional connectivityPolygenic riskFrontoparietal systemCognitive abilitiesFMRI paradigmNeural mechanismsSchizophrenia polygenic risk scoresBrain networksFunctional connectivityFMRI dataHeritable mental disorderConnectome ProjectVisual systemNeuropsychiatric PhenomicsFunctional dysconnectivityGenetic liabilityMental disordersSchizophrenia
2021
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder
Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 2021, 53: 1196-1204. PMID: 34231451, PMCID: PMC8738774, DOI: 10.1017/s003329172100266x.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide significant single nucleotide polymorphismsLarge-scale genome-wide association studiesSignificant single nucleotide polymorphismsIndependent genome-wide significant single nucleotide polymorphismsSignificant genetic correlationsGenomic regionsSingle nucleotide polymorphismsGene expressionGenetic covariancePleiotropic associationsAssociation studiesGenetic correlationsGenetic variantsNucleotide polymorphismsGenetic overlapDisorder-specific effectsAlcohol use disorderGenetic influencesGenesUse disorders