2020
Ordinal Outcomes Are Superior to Binary Outcomes for Designing and Evaluating Clinical Trials in Compensated Cirrhosis
D’Amico G, Abraldes JG, Rebora P, Valsecchi MG, Garcia‐Tsao G. Ordinal Outcomes Are Superior to Binary Outcomes for Designing and Evaluating Clinical Trials in Compensated Cirrhosis. Hepatology 2020, 72: 1029-1042. PMID: 31837238, PMCID: PMC11090179, DOI: 10.1002/hep.31070.Peer-Reviewed Original ResearchConceptsClinical trialsGrade 1Prevention of decompensationBaseline platelet countDevelopment of varicesSignificant outcome differencesLow baseline riskPrimary therapeutic targetCirrhosis decompensationCompensated cirrhosisInception cohortComposite endpointEsophageal varicesPlatelet countBinary outcomesDisease progressionSignificant treatment effectBaseline riskGrade 3Sample sizeOutcome differencesTherapeutic targetDecompensationGrade 2Larger sample sizeAttribution of Nonalcoholic Steatohepatitis as an Etiology of Cirrhosis for Clinical Trials Eligibility: Recommendations From the Multi-stakeholder Liver Forum
Noureddin M, Chan J, Barradas K, Dimick-Santos L, Schabel E, Omokaro S, Anania F, Myers R, Miller V, Sanyal A, Chalasani N, Group L, Anania F, Bajaj J, Barradas K, Berzigotti A, Birman P, Bosch J, Brower A, Calboli D, Chalasani N, Chan J, Charlton W, Dickinson K, Dimick-Santos L, Filozof C, Forsgren M, Fuchs M, Garcia-Tsao G, Gonzalez-Abraldes J, Gruss H, Hansen M, Hosman S, Imperial J, Jones D, Lalazar G, Leinhard O, Lyons E, McColgan B, Mehta R, Mesenbrink P, Miller V, Myers R, Noureddin M, Omokaro S, Pei V, Ratziu V, Regev A, Riccio R, Sanyal A, Schabel E, Seo S, Smith A, Szitanyi P, Traber P. Attribution of Nonalcoholic Steatohepatitis as an Etiology of Cirrhosis for Clinical Trials Eligibility: Recommendations From the Multi-stakeholder Liver Forum. Gastroenterology 2020, 159: 422-427.e1. PMID: 32353369, DOI: 10.1053/j.gastro.2020.04.039.Commentaries, Editorials and Letters
1998
Portal hypertension and variceal bleeding: An AASLD single topic symposium
Grace N, Groszmann R, Garcia‐Tsao G, Burroughs A, Pagliaro L, Makuch R, Bosch J, Stiegmann G, Henderson J, de Franchis R, Wagner J, Conn H, Rodes J. Portal hypertension and variceal bleeding: An AASLD single topic symposium. Hepatology 1998, 28: 868-880. PMID: 9731585, DOI: 10.1002/hep.510280339.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial
Bosch J, Groszmann R, García‐Pagán J, Terés J, García‐Tsao G, Navasa M, Mas A, Rodés J. Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial. Hepatology 1989, 10: 962-968. PMID: 2511136, DOI: 10.1002/hep.1840100612.Peer-Reviewed Original ResearchConceptsTransdermal nitroglycerinVariceal hemorrhageVariceal bleedingPlacebo-controlled clinical trialActive variceal bleedingEffectiveness of vasopressinDouble-blind techniqueSlow-release preparationHospital mortalityTransfusion requirementsRecurrent bleedingBalloon tamponadeCirrhotic patientsEmergency surgeryVasopressin infusionClinical trialsDefinitive controlDrug combinationsTotal doseNitroglycerinBleedingHemorrhagePatientsInitial controlVasopressin
1988
Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial
Grace N, Conn H, Resnick R, Groszmann R, Atterbury C, Wright S, Gusberg R, Vollman R, Garcia‐Tsao G, Fisher R, O'Hara E, McDermott W, Maselli J, Widrich W, Matloff D, Horst D, Banks N, Alberts J. Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial. Hepatology 1988, 8: 1475-1481. PMID: 3056820, DOI: 10.1002/hep.1840080602.Peer-Reviewed Original ResearchConceptsDistal splenorenal shunt groupPortal-systemic shuntsDistal splenorenal shuntShunt groupSplenorenal shuntVariceal hemorrhageMajor variceal hemorrhageReasonable operative riskRecurrent variceal hemorrhageGroup of patientsPortal venous flowShunt patientsAngiographic evidenceLate mortalityOperative mortalityCirrhotic patientsLiver groupOperative riskRenal veinInferior venaAngiographic demonstrationVenous flowPatientsTotal mortalityShuntColchicine in the Treatment of Cirrhosis of the Liver
Kershenobich D, Vargas F, Garcia-Tsao G, Tamayo R, Gent M, Rojkind M. Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal Of Medicine 1988, 318: 1709-1713. PMID: 3287167, DOI: 10.1056/nejm198806303182602.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicColchicineDouble-Blind MethodFemaleFollow-Up StudiesHepatitisHumansLiver CirrhosisLiver Cirrhosis, AlcoholicMaleMiddle AgedRandom AllocationConceptsTreatment of cirrhosisPlacebo groupHistologic improvementColchicine groupSurvival rateMinimal portal fibrosisPlacebo-controlled trialPercent of patientsUse of colchicineAlcoholic cirrhosisOverall survivalPortal fibrosisMore biopsiesHepatic cirrhosisLiver biopsyPosthepatitic cirrhosisHistologic studyC. FiftyCirrhosisSide effectsPatientsCollagen synthesisLiverBiopsyPreliminary evidence
1987
Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions
Blei A, Garcia-Tsao G, Groszmann R, Kahrilas P, Ganger D, Morse S, Fung H. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions. Gastroenterology 1987, 93: 576-583. PMID: 3301517, DOI: 10.1016/0016-5085(87)90921-8.Peer-Reviewed Original ResearchConceptsIsosorbide dinitratePortal pressureArterial pressureHemodynamic changesHemodynamic evaluationHepatic vein wedge pressureHepatic venous gradientSystemic hemodynamic changesMean arterial pressureEffects of placeboValues 4 hStable cirrhoticsAlcoholic cirrhosisCardiac indexPortal hypertensionWedge pressureHemodynamic benefitsVenous gradientVasoactive metabolitesPharmacologic agentsIndividual patientsBaseline valuesExperimental animalsDinitratePatientsPortal hemodynamics during nitroglycerin administration in cirrhotic patients
Garcia‐Tsao G, Groszmann R. Portal hemodynamics during nitroglycerin administration in cirrhotic patients. Hepatology 1987, 7: 805-809. PMID: 3115881, DOI: 10.1002/hep.1840070502.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientEffects of nitroglycerinMean arterial pressurePortal pressureArterial pressureNitroglycerin administrationBlood flowExperimental animalsAzygos blood flowPortal venous hemodynamicsPortal hypertensive patientsPortal blood flowVenous dilatorHypertensive patientsAlcoholic cirrhosisArterial vasodilatorCirrhotic patientsBlood pressurePortal hemodynamicsSublingual nitroglycerinVenous hemodynamicsHemodynamic responsePeak changesHeart rate