2024
An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study
Dunn W, Li Y, Singal A, Simonetto D, Díaz L, Idalsoaga F, Ayares G, Arnold J, Ayala-Valverde M, Perez D, Gomez J, Escarate R, Fuentes-López E, Ramirez-Cadiz C, Morales-Arraez D, Zhang W, Qian S, Ahn J, Buryska S, Mehta H, Dunn N, Waleed M, Stefanescu H, Bumbu A, Horhat A, Attar B, Agrawal R, Cabezas J, Echavaría V, Cuyàs B, Poca M, Soriano G, Sarin S, Maiwall R, Jalal P, Higuera-de-la-Tijera F, Kulkarni A, Rao P, Guerra-Salazar P, Skladaný L, Kubánek N, Prado V, Clemente-Sanchez A, Rincon D, Haider T, Chacko K, Romero G, Pollarsky F, Restrepo J, Toro L, Yaquich P, Mendizabal M, Garrido M, Marciano S, Dirchwolf M, Vargas V, Jiménez C, Hudson D, García-Tsao G, Ortiz G, Abraldes J, Kamath P, Arrese M, Shah V, Bataller R, Arab J. An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study. Hepatology 2024, 80: 1196-1211. PMID: 38607809, DOI: 10.1097/hep.0000000000000883.Peer-Reviewed Original ResearchAlcohol-associated hepatitisValidation cohortArtificial intelligenceModified Glasgow scoreMaddrey's discriminant functionMortality rateGlobal cohort studyShort-term mortalityPost-test probabilityApproximate mortality ratesSteroid therapyGlasgow scoreAH patientsSteroid useTransplant indicationRetrospective studyDerivation cohortLaboratory valuesCohort studyClinical trialsGlobal cohortPrognostic modelScoring systemAI algorithmsCohortSerum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis
Yamazaki T, Kouno T, Hsu C, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Schnabl B. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology 2024, 80: 403-417. PMID: 38377466, PMCID: PMC11268475, DOI: 10.1097/hep.0000000000000777.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAlcohol use disorderSevere AHAH patientsAhR activationMicrobiota-derived tryptophan metabolitesSurvival rateAssociated with high mortalityCumulative survival rateAssociated with survivalAryl hydrocarbon receptor activationMulticenter cohortFecal metabolomePrognostic markerTryptophan metabolitesReceptor activationAryl hydrocarbon receptorPatientsUse disorderAH cohortSerumHigher mortalityAhRHepatitisCohort
2022
SAT496 SBP vs. non-SBP bacterial infections at admission have comparable outcomes in a multi-center cohort of inpatients with cirrhosis
O’Leary J, Reddy K, Tandon P, Kamath P, Garcia-Tsao G, Wong F, Lai J, Subramanian R, Thuluvath P, Maliakkal B, Vargas H, Biggins S, Thacker L, Bajaj J. SAT496 SBP vs. non-SBP bacterial infections at admission have comparable outcomes in a multi-center cohort of inpatients with cirrhosis. Journal Of Hepatology 2022, 77: s887-s888. DOI: 10.1016/s0168-8278(22)02066-9.Peer-Reviewed Original ResearchSa1456: SBP VERSUS NON-SBP BACTERIAL INFECTIONS AT ADMISSION HAVE COMPARABLE OUTCOMES IN A MULTI-CENTER COHORT OF INPATIENTS WITH CIRRHOSIS
O'Leary J, Reddy K, Tandon P, Kamath P, Garcia-Tsao G, Wong F, Lai J, Subramanian R, Thuluvath P, Maliakkal B, Vargas H, Biggins S, Thacker L, Bajaj J. Sa1456: SBP VERSUS NON-SBP BACTERIAL INFECTIONS AT ADMISSION HAVE COMPARABLE OUTCOMES IN A MULTI-CENTER COHORT OF INPATIENTS WITH CIRRHOSIS. Gastroenterology 2022, 162: s-1175-s-1176. DOI: 10.1016/s0016-5085(22)63501-7.Peer-Reviewed Original Research256: PRIOR PERIODONITIS AND PATIENT-REPORTED OUTCOMES PREDICT THE RISK OF 3-MONTH HOSPITALIZATION IN A MULTI-CENTER CIRRHOSIS COHORT
Bajaj J, Lai J, Tandon P, O'Leary J, Garcia-Tsao G, Wong F, Vargas H, Kamath P, Biggins S, Shaw J, Limon-Miro A, Chew M, Mbachi C, Thacker L, Reddy R. 256: PRIOR PERIODONITIS AND PATIENT-REPORTED OUTCOMES PREDICT THE RISK OF 3-MONTH HOSPITALIZATION IN A MULTI-CENTER CIRRHOSIS COHORT. Gastroenterology 2022, 162: s-54. DOI: 10.1016/s0016-5085(22)60136-7.Peer-Reviewed Original Research
2021
Cirrhosis Is Associated With High Mortality and Readmissions Over 90 Days Regardless of COVID‐19: A Multicenter Cohort
Bajaj JS, Garcia‐Tsao G, Wong F, Biggins SW, Kamath PS, McGeorge S, Chew M, Pearson M, Shaw J, Kalluri A, Fagan A, Olofson A, Moini M, de la Rosa Rodriguez R, Reddy KR. Cirrhosis Is Associated With High Mortality and Readmissions Over 90 Days Regardless of COVID‐19: A Multicenter Cohort. Liver Transplantation 2021, 27: 1343-1347. PMID: 33427401, PMCID: PMC8014819, DOI: 10.1002/lt.25981.Peer-Reviewed Original Research
2020
Reduced Clot Stability by Thromboelastography as a Potential Indicator of Procedure‐Related Bleeding in Decompensated Cirrhosis
Zanetto A, Rinder HM, Senzolo M, Simioni P, Garcia‐Tsao G. Reduced Clot Stability by Thromboelastography as a Potential Indicator of Procedure‐Related Bleeding in Decompensated Cirrhosis. Hepatology Communications 2020, 5: 272-282. PMID: 33553974, PMCID: PMC7850311, DOI: 10.1002/hep4.1641.Peer-Reviewed Original ResearchConceptsProcedure-related bleedingTEG maximum amplitudeNonbleeding patientsDecompensated cirrhosisPlatelet countTEG parametersCoagulation testsClot stabilityLife-threatening bleedingConventional coagulation testsInternational normalized ratioRoutine coagulation testsPreprocedural prophylaxisProspective cohortLethal complicationProspective studyNormalized ratioCirrhosisBleedingLarge cohortHigh riskPatientsThromboelastographyΑ angleCohortSGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension
Saffo S, Garcia‐Tsao G, Taddei T. SGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension. Journal Of Diabetes 2020, 13: 265-269. PMID: 33210815, DOI: 10.1111/1753-0407.13136.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBenzhydryl CompoundsCohort StudiesDiabetes Mellitus, Type 2FemaleGlucosidesGlycated HemoglobinHumansHypertension, PortalLiver CirrhosisMaleMiddle AgedOutcome Assessment, Health CarePolyuriaSodium-Glucose Transporter 2 InhibitorsTertiary Care CentersUrinary Tract InfectionsYoung AdultConceptsSGLT2 inhibitorsPortal hypertensionDiabetes mellitusSodium-glucose cotransporter 2 inhibitorsGlucose cotransporter 2 inhibitorsCenter cohort studyCotransporter 2 inhibitorsCohort of patientsPotential therapeutic targetFavorable pleiotropic effectsCohort studyRenal diseaseClinical trialsClinical dataTherapeutic targetPatientsCirrhosisHypertensionMellitusOngoing evaluationInhibitorsPleiotropic effectsCohortDiseaseTrials
2019
Su1527 – Potentially Preventable Readmissions and Complications in Hospitalized Patients with Hepatic Encephalopathy in a Large Multi-Center Cohort
Bajaj J, Tandon P, O’Leary J, Wong F, Garcia-Tsao G, Biggins S, Kamath P, Thuluvath P, Lai J, Vargas H, Subramanian R, Maliakkal B, Fallon M, Thacker L, Reddy K. Su1527 – Potentially Preventable Readmissions and Complications in Hospitalized Patients with Hepatic Encephalopathy in a Large Multi-Center Cohort. Gastroenterology 2019, 156: s-562. DOI: 10.1016/s0016-5085(19)38297-6.Peer-Reviewed Original Research573 – Predictive Factors for the Development of Acute-Onchronic Liver Failure in a North American Cohort of Hospitalized Cirrhotic Patients with Decompensation
Wong F, Reddy K, Tandon P, O'Leary J, Garcia-Tsao G, Lai J, Vargas H, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. 573 – Predictive Factors for the Development of Acute-Onchronic Liver Failure in a North American Cohort of Hospitalized Cirrhotic Patients with Decompensation. Gastroenterology 2019, 156: s-1205. DOI: 10.1016/s0016-5085(19)39995-0.Peer-Reviewed Original ResearchTargets to improve quality of care for patients with hepatic encephalopathy: data from a multi‐centre cohort
Bajaj JS, O’Leary J, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia‐Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR. Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi‐centre cohort. Alimentary Pharmacology & Therapeutics 2019, 49: 1518-1527. PMID: 31032966, PMCID: PMC6538445, DOI: 10.1111/apt.15265.Peer-Reviewed Original ResearchConceptsQuality of careAspiration pneumoniaEnd-stage Liver Disease cohortLiver disease cohortMulti-center cohortNorth American ConsortiumLiver transplantMELD scoreCirrhotic patientsDual therapyHepatic encephalopathyPneumonia developmentReadmission analysisBetter prognosisPatient cohortTherapy patientsDisease cohortLarge cohortPatientsMedicationsCohortAmerican ConsortiumTherapyReadmissionPneumoniaSAT-013-Potentially Preventable readmissions and complications in hospitalized patients with hepatic encephalopathy in a large multi-center cohort
Bajaj J, Tandon P, O’leary J, Wong F, Garcia-Tsao G, Biggins S, Kamath P, Thuluvath P, Lai J, Vargas H, Subramanian R, Maliakkal B, Fallon M, Thacker L, Reddy R. SAT-013-Potentially Preventable readmissions and complications in hospitalized patients with hepatic encephalopathy in a large multi-center cohort. Journal Of Hepatology 2019, 70: e630-e631. DOI: 10.1016/s0618-8278(19)31256-3.Peer-Reviewed Original ResearchSAT-139-Predictive factors for the development of acute-on-chronic liver failure in a North American cohort of hospitalized patients with cirrhosis and decompensation
Wong F, Reddy R, Tandon P, O’leary J, Garcia-Tsao G, Lai J, Vargas H, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. SAT-139-Predictive factors for the development of acute-on-chronic liver failure in a North American cohort of hospitalized patients with cirrhosis and decompensation. Journal Of Hepatology 2019, 70: e691-e692. DOI: 10.1016/s0618-8278(19)31378-7.Peer-Reviewed Original Research
2015
P0120 : The 3-month readmission rate remains unacceptably high in a large multi-center cohort of cirrhotic patients
Bajaj J, Reddy K, Garcia-Tsao G, Wong F, Fallon M, Subramanian R, Biggins S, Maliakkal B, Kamath P, Thuluvath P, Thacker L, O’leary J, behalf of NACSELD. O. P0120 : The 3-month readmission rate remains unacceptably high in a large multi-center cohort of cirrhotic patients. Journal Of Hepatology 2015, 62: s345-s346. DOI: 10.1016/s0168-8278(15)30340-8.Peer-Reviewed Original Research575 The 3-Month Readmission Rate Remains Unacceptably High in a Large Multi-Center Cohort of Cirrhotic Patients
Bajaj J, Reddy K, Garcia-Tsao G, Wong F, Fallon M, Subramanian R, Biggins S, Maliakkal B, Kamath P, Thuluvath P, Thacker L, O'Leary J. 575 The 3-Month Readmission Rate Remains Unacceptably High in a Large Multi-Center Cohort of Cirrhotic Patients. Gastroenterology 2015, 148: s-982-s-983. DOI: 10.1016/s0016-5085(15)33360-6.Peer-Reviewed Original ResearchP0119 : Validation Of The NACSELD Infection-Related Acute-on-Chronic Liver Failure (I-ACLF) score in an independent multicenter cohort
O’Leary J, Reddy K, Garcia-Tsao G, Biggins S, Wong F, Fallon M, Subramanian R, Kamath P, Thuluvath P, Maliakkal B, Patton H, Tandon P, Thacker L, Bajaj J, behalf of NACSESLD. O. P0119 : Validation Of The NACSELD Infection-Related Acute-on-Chronic Liver Failure (I-ACLF) score in an independent multicenter cohort. Journal Of Hepatology 2015, 62: s345. DOI: 10.1016/s0168-8278(15)30339-1.Peer-Reviewed Original Research