2015
BMP signaling and microtubule organization regulate synaptic strength
Ball R, Peled E, Guerrero G, Isacoff E. BMP signaling and microtubule organization regulate synaptic strength. Neuroscience 2015, 291: 155-166. PMID: 25681521, PMCID: PMC4369397, DOI: 10.1016/j.neuroscience.2015.01.069.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAnimals, Genetically ModifiedBone Morphogenetic ProteinsCalciumDNA-Binding ProteinsDrosophilaDrosophila ProteinsFemaleFluorescent DyesImmunohistochemistryMicrotubule-Associated ProteinsMicrotubulesNeuromuscular JunctionPatch-Clamp TechniquesPresynaptic TerminalsReceptors, Cell SurfaceSynaptic TransmissionTranscription FactorsConceptsBone morphogenetic proteinMicrotubule organizationGlutamatergic Drosophila neuromuscular junctionDrosophila neuromuscular junctionLarval neuromuscular junctionDistal boutonsNeuromuscular junctionBMP pathwaySynaptic transmissionMorphogenetic proteinsSynaptic growthMolecular pathwaysSynaptic strengthMicrotubule systemHomeostatic regulationPathwayMicrotubulesSpastin mutationsPostsynaptic partnersMutationsTransmission strengthSelective mannerMuscle fibersProteinRegulation
2010
A Comprehensive Linkage Map of the Dog Genome
Wong A, Ruhe A, Dumont B, Robertson K, Guerrero G, Shull S, Ziegle J, Millon L, Broman K, Payseur B, Neff M. A Comprehensive Linkage Map of the Dog Genome. Genetics 2010, 184: 595-605. PMID: 19966068, PMCID: PMC2828735, DOI: 10.1534/genetics.109.106831.Peer-Reviewed Original ResearchConceptsLinkage mapUnique biologyReference sequenceLinkage disequilibriumComplete linkage mapComprehensive linkage mapSex-averaged mapPhase-known meiosesNonmodel organismsDog genomeSelective sweepsGenomewide patternsMultipoint linkage analysisReference genomeEvolutionary adaptationMicrosatellite markersFramework mapRecombination rateLinkage analysisMap assemblyGenotype dataSex-specific differencesGenomeMeiosisHuman disease counterparts
2005
Heterogeneity in synaptic transmission along a Drosophila larval motor axon
Guerrero G, Reiff D, Agarwal G, Ball R, Borst A, Goodman C, Isacoff E. Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nature Neuroscience 2005, 8: 1188-1196. PMID: 16116446, PMCID: PMC1402256, DOI: 10.1038/nn1526.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsCalcium SignalingDiagnostic ImagingDrosophilaDrosophila ProteinsElectric StimulationEvoked PotentialsGene Expression Regulation, DevelopmentalImmunohistochemistryLarvaLuminescent ProteinsMembrane PotentialsMotor NeuronsMutagenesis, InsertionalNeuromuscular JunctionPatch-Clamp TechniquesSynaptic TransmissionConceptsNeuromuscular junctionGlutamate receptorsSynaptic transmissionAxonal branchesMotor axonsPostsynaptic terminalsIndividual boutonsBoutonsProximal connectionLarval neuromuscular junctionTransmission strengthLarval motor axonsDrosophila melanogaster larval neuromuscular junctionDistal boutonsDistal onesHigh Ca2Ca2InfluxAxonsReceptorsIn Vivo Performance of Genetically Encoded Indicators of Neural Activity in Flies
Reiff D, Ihring A, Guerrero G, Isacoff E, Joesch M, Nakai J, Borst A. In Vivo Performance of Genetically Encoded Indicators of Neural Activity in Flies. Journal Of Neuroscience 2005, 25: 4766-4778. PMID: 15888652, PMCID: PMC1464576, DOI: 10.1523/jneurosci.4900-04.2005.Peer-Reviewed Original ResearchAnimalsAnimals, Genetically ModifiedDose-Response Relationship, RadiationDrosophilaElectric StimulationFluorescence Resonance Energy TransferFluorescent DyesGene Expression RegulationGenetic EngineeringImmunohistochemistryIn Vitro TechniquesLarvaLuminescent ProteinsMicroscopy, ConfocalMolecular Probe TechniquesNeuromuscular JunctionNeuronsPresynaptic TerminalsReproducibility of ResultsTime Factors
2001
Genetically encoded optical sensors of neuronal activity and cellular function
Guerrero G, Isacoff E. Genetically encoded optical sensors of neuronal activity and cellular function. Current Opinion In Neurobiology 2001, 11: 601-607. PMID: 11595495, DOI: 10.1016/s0959-4388(00)00256-7.Peer-Reviewed Original ResearchConceptsCellular signalsFluorescent proteinSpecific cellular signalsCellular functionsIntracellular messengerSpecific mutationsStructural rearrangementsFP fluorescenceCyclic nucleotidesNeurotransmitter releaseNew insightsProteinMembrane voltageOptical sensorsNeural circuitsNucleotidesFluorescenceMessengerMutationsRearrangementNitric oxideSignalsChemical environmentNeuronal activityFusion
2000
Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2α
Kramer P, Guerrero G, Krishnamurthy R, Mitchell P, Wray S. Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2α. Cells And Development 2000, 94: 79-94. PMID: 10842061, DOI: 10.1016/s0925-4773(00)00316-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationDNA-Binding ProteinsEmbryonic InductionEpithelial CellsFemaleGene Expression Regulation, DevelopmentalGonadotropin-Releasing HormoneIntermediate Filament ProteinsMaleMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Mutant StrainsNasal CavityNerve Tissue ProteinsNeural Cell Adhesion MoleculesNeuronsOlfactory MucosaOlfactory PathwaysPeripherinsTrans-ActivatorsTranscription Factor AP-2Transcription FactorsConceptsLHRH neuronsHormone-releasing hormoneRespiratory epitheliumNeural cell adhesion moleculeOlfactory epitheliumExpression of LHRHPeripherin-positive fibersNasal placodeIntermediate filament protein peripherinMain olfactory epitheliumTranscription factor APOlfactory epithelial structuresAP-2alphaOlf-1Embryonic day 12.5NCAM stainingCell adhesion moleculeEpithelial areaAP-2alpha expressionMutant miceCell groupsProtein peripherinAdhesion moleculesNeuronsEpithelium