2020
George A. Beller, MD (Born 1940)
Wackers FJT, Corner T. George A. Beller, MD (Born 1940). Journal Of Nuclear Cardiology 2020, 27: 723-725. PMID: 32367225, DOI: 10.1007/s12350-020-02115-2.Peer-Reviewed Original Research
2015
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing
Jovin IS, Ebisu KA, Oprea AD, Brandt CA, Natale D, Finta LA, Dziura J, Wackers FJ. The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing. Journal Of Nuclear Cardiology 2015, 23: 773-779. PMID: 26338428, DOI: 10.1007/s12350-015-0268-3.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsOdds ratioPerfusion defectsMyocardial perfusion stress testMyocardial perfusion stress testingStress testStress myocardial perfusion scansMyocardial single photon emissionAdenosine stress testInfluence of clopidogrelLikelihood of ischemiaMyocardial perfusion testingUse of clopidogrelCoronary vascular toneExercise stress testMyocardial perfusion scanMyocardial perfusion imagingSingle photon emissionAdenosine receptor antagonistDiagnosis of ischemiaPerfusion scanPerfusion testingVascular toneReceptor antagonistTomography scan
2011
85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
Jain M, Nkonde C, Lin BA, Walker A, Wackers FJ. 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing. Journal Of Nuclear Cardiology 2011, 18: 1026-1035. PMID: 21922347, DOI: 10.1007/s12350-011-9454-0.Peer-Reviewed Original ResearchConceptsMaximal age-predicted heart rateAge-predicted heart rateInducible ischemiaPeak exerciseExercise testingPositive ECGHeart rateExercise endpointPositive exercise ECGExercise treadmill testingRegistry patientsProspective registryExercise capacityRetrospective cohortTreadmill testingPatient cohortExercise ECGValid endpointPatientsMore womenEndpointIschemiaClinical laboratoriesECGCohort
2009
Customized Exercise Testing⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Wackers FJ. Customized Exercise Testing⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology. Journal Of The American College Of Cardiology 2009, 54: 546-548. PMID: 19643317, DOI: 10.1016/j.jacc.2009.04.044.Peer-Reviewed Original ResearchCardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes : The DIAD Study: A Randomized Controlled Trial
Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE, Investigators F. Cardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes : The DIAD Study: A Randomized Controlled Trial. JAMA 2009, 301: 1547-1555. PMID: 19366774, PMCID: PMC2895332, DOI: 10.1001/jama.2009.476.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseType 2 diabetesNonfatal myocardial infarctionAsymptomatic coronary artery diseaseMyocardial perfusion imagingCardiac event rateMyocardial infarctionCardiac deathMPI defectsCardiac outcomesEvent ratesScreened groupArtery diseaseSymptoms of CADRadionuclide myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyHigh cardiac riskLow event ratesPositive predictive valueDetection of ischemiaPrimary medical preventionCoronary revascularizationDiabetes clinicIdentifies patientsControlled Trials
2007
Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increase
2006
Letter to the Editor
Venkataraman R, Al-Shaer M, Wackers F. Letter to the Editor. Journal Of Nuclear Cardiology 2006, 13: 300. PMID: 16580967, DOI: 10.1016/j.nuclcard.2006.01.009.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonographyTo the editor
Venkataraman R, Al-Shaer M, Wackers F. To the editor. Journal Of Nuclear Cardiology 2006, 13: 300-300. DOI: 10.1007/bf02971255.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonographyScreening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring
Scholte A, Bax J, Wackers F. Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring. Journal Of Nuclear Cardiology 2006, 13: 11-18. PMID: 16464712, DOI: 10.1016/j.nuclcard.2005.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2Diagnosis, Computer-AssistedExercise TestHumansIncidenceMass ScreeningPrognosisRadionuclide ImagingReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySurvival RateVentricular Dysfunction, LeftConceptsSilent coronary artery diseaseCoronary artery diseaseCoronary calcium scoringType 2 diabetes mellitusMyocardial perfusion imagingArtery diseaseDiabetes mellitusCalcium scoringPerfusion imagingAsymptomatic individualsStress myocardial perfusion imagingRadionuclide myocardial perfusion imagingEarly appropriate treatmentRecent prospective studiesRates of morbidityAsymptomatic patientsCardiovascular complicationsProspective studyOverall prevalenceClinical combinationAppropriate treatmentClinical investigationMellitusClinical importanceDisease
2004
Cardiac Abnormalities in Diabetic Patients With Neuropathy
Johnson BF, Nesto RW, Pfeifer MA, Slater WR, Vinik AI, Chyun DA, Law G, Wackers FJ, Young LH. Cardiac Abnormalities in Diabetic Patients With Neuropathy. Diabetes Care 2004, 27: 448-454. PMID: 14747227, DOI: 10.2337/diacare.27.2.448.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde ReductaseBenzothiazolesCardiac OutputDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesDouble-Blind MethodEnzyme InhibitorsExercise TestFemaleHeartHeart Conduction SystemHeart RateHumansMaleMiddle AgedPhthalazinesPlacebosStroke VolumeThiazolesVentricular Function, LeftConceptsLeft ventricular ejection fractionDiabetic patientsARI treatmentCardiac outputStroke volumeCardiac abnormalitiesAldose reductase inhibitorExercise left ventricular ejection fractionAbnormal heart rate variabilityDiastolic peak filling rateAsymptomatic cardiac abnormalitiesGated radionuclide ventriculographyMaximal bicycle exercisePlacebo-treated subjectsDiastolic filling rateVentricular ejection fractionCoronary artery diseaseValvular heart diseasePeak filling rateExercise cardiac outputLV stroke volumeHeart rate variabilityBlinded treatmentInsulin useArtery disease
2003
Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
Abbott B, Afshar M, Berger A, Wackers F. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. Journal Of Nuclear Cardiology 2003, 10: 9-16. PMID: 12569326, DOI: 10.1067/mnc.2002.127625.Peer-Reviewed Original ResearchConceptsNormal myocardial perfusion imagingAdenosine myocardial perfusion imagingST-segment depressionMyocardial perfusion imagingIschemic ECG changesCardiac eventsECG changesAdenosine infusionCardiac deathPrognostic significanceECG groupNormal myocardial perfusion imagesBaseline electrocardiographic abnormalitiesAdverse cardiac eventsIschemic electrocardiographic changesNonfatal myocardial infarctionSubsequent cardiac eventsFuture cardiac eventsNormal myocardial perfusionSex-matched groupPerfusion imagesECG evidenceElectrocardiographic abnormalitiesIndependent predictorsElectrocardiographic changes
2002
Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise. Journal Of Nuclear Cardiology 2002, 9: 188-196. PMID: 11986564, DOI: 10.1067/mnc.2002.119973.Peer-Reviewed Original ResearchConceptsLow-level treadmill exerciseMyocardial perfusion imagingTreadmill exerciseElectrocardiographic changesAdverse effectsAdenosine myocardial perfusion imagingSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingIschemic electrocardiographic changesLow-level exerciseMore adverse effectsUnfavorable side effectsSingle photon emissionAdenosine studyAdenosine TcMore patientsMyocardial ischemiaHemodynamic responseStress perfusionSide effectsPerfusion imagingTracer uptakePatientsMPI studies
2001
Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imaging
2000
Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpointAn economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial
Stowers S, Eisenstein E, Wackers F, Berman D, Blackshear J, Jones A, Szymanski T, Lam L, Simons T, Natale D, Paige K, Wagner G. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial. Annals Of Emergency Medicine 2000, 35: 17-25. PMID: 28140201, DOI: 10.1016/s0196-0644(00)70100-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainClinical ProtocolsCoronary AngiographyCost ControlElectrocardiographyEmergency TreatmentExercise TestFemaleHospital CostsHumansLength of StayMaleMedicareMiddle AgedMyocardial InfarctionReproducibility of ResultsRisk FactorsSingle-Blind MethodTomography, Emission-Computed, Single-PhotonUnited StatesConceptsEarly exercise stress testingExercise stress testingLength of stayChest painHospital costsSingle photon emissionCoronary angiographyStress testingDiagnostic strategiesTomography myocardial perfusion imagingCost/charge ratiosAggressive diagnostic strategyNegative scan resultsPositive scan resultsAcute chest painIntermediate-risk patientsAcute coronary syndromeExercise treadmill testingAdverse clinical outcomesShorter median lengthEmergency department patientsAcute myocardial infarctionScan resultsMyocardial perfusion imagingPhoton emission
1999
Risk Stratification Soon After Acute Infarction
Wackers F, Zaret B. Risk Stratification Soon After Acute Infarction. Circulation 1999, 100: 2040-2042. PMID: 10562256, DOI: 10.1161/01.cir.100.20.2040.Peer-Reviewed Original ResearchCan acute rest imaging shorten evaluation in chest pain centers?
Wackers F. Can acute rest imaging shorten evaluation in chest pain centers? Journal Of Nuclear Cardiology 1999, 6: 676-678. PMID: 10608597, DOI: 10.1016/s1071-3581(99)90106-x.Peer-Reviewed Original Research
1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patientsProcedure guideline for myocardial perfusion imaging. Society of Nuclear Medicine.
Strauss H, Miller D, Wittry M, Cerqueira M, Garcia E, Iskandrian A, Schelbert H, Wackers F. Procedure guideline for myocardial perfusion imaging. Society of Nuclear Medicine. Journal Of Nuclear Medicine 1998, 39: 918-23. PMID: 9591601.Peer-Reviewed Original Research
1997
Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease
Gradel C, Jain D, Batsford W, Wackers F, Zaret B. Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 379-386. PMID: 9362014, DOI: 10.1016/s1071-3581(97)90029-5.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingSustained ventricular tachycardiaPerfusion defect sizeVentricular tachycardiaElectrophysiological studiesArtery diseaseIndependent predictorsMultivariate analysisChronic coronary artery diseaseLeft ventricular ejection fractionSustained monomorphic ventricular tachycardiaGlobal left ventricular functionVentricular ejection fractionLeft ventricular functionPrevious myocardial infarctionMonomorphic ventricular tachycardiaBest independent predictorSize of ischemiaAdditional ischemiaArrhythmia historyInducible patientsNoninducible patientsSize of scarClinical predictors