2006
The Association of Psychological Factors, Physical Activity, Neuropathy, and Quality of Life in Type 2 Diabetes
Chyun DA, Melkus GD, Katten DM, Price WJ, Davey JA, Grey N, Heller G, Wackers FJ. The Association of Psychological Factors, Physical Activity, Neuropathy, and Quality of Life in Type 2 Diabetes. Biological Research For Nursing 2006, 7: 279-288. PMID: 16581898, DOI: 10.1177/1099800405285748.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnxietyAttitude to HealthConnecticutCoronary DiseaseCross-Sectional StudiesDepressionDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHostilityHumansLinear ModelsMaleMiddle AgedMotor ActivityMultivariate AnalysisQuality of LifeRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesVirginiaConceptsQuality of lifeBody mass indexDepressive symptomsMass indexPhysical inactivityMedical Outcomes Study Short Form-36Diabetes-related microvascular complicationsHigher body mass indexPoor QOLAsymptomatic Diabetics (DIAD) studyCardiac risk factorsDiabetes-related factorsShort Form-36Type 2 diabetesPsychological factorsDetection of ischemiaMicrovascular complicationsForm-36Diabetes QualityFemale sexRisk factorsAncillary studiesDiabetic studyPhysical activityType 2
2003
Use of radionuclide imaging in acute coronary syndromes
Abbott B, Wackers F. Use of radionuclide imaging in acute coronary syndromes. Current Cardiology Reports 2003, 5: 25-31. PMID: 12493157, DOI: 10.1007/s11886-003-0034-z.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMyocardial infarctionChest painCoronary syndromeEmergency departmentPerfusion imagingRadionuclide myocardial perfusion imagingAcute chest painTriage of patientsAcute myocardial infarctionPerfusion imaging studyMyocardial perfusion imagingNegative predictive valueReperfusion therapyED evaluationRoutine careRandomized trialsRisk stratificationInfarct sizePrognostic valueDiagnostic challengeUnnecessary hospitalizationPredictive valueTesting modalitiesImaging studiesPrognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
Abbott B, Afshar M, Berger A, Wackers F. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. Journal Of Nuclear Cardiology 2003, 10: 9-16. PMID: 12569326, DOI: 10.1067/mnc.2002.127625.Peer-Reviewed Original ResearchConceptsNormal myocardial perfusion imagingAdenosine myocardial perfusion imagingST-segment depressionMyocardial perfusion imagingIschemic ECG changesCardiac eventsECG changesAdenosine infusionCardiac deathPrognostic significanceECG groupNormal myocardial perfusion imagesBaseline electrocardiographic abnormalitiesAdverse cardiac eventsIschemic electrocardiographic changesNonfatal myocardial infarctionSubsequent cardiac eventsFuture cardiac eventsNormal myocardial perfusionSex-matched groupPerfusion imagesECG evidenceElectrocardiographic abnormalitiesIndependent predictorsElectrocardiographic changes
2002
Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise. Journal Of Nuclear Cardiology 2002, 9: 188-196. PMID: 11986564, DOI: 10.1067/mnc.2002.119973.Peer-Reviewed Original ResearchConceptsLow-level treadmill exerciseMyocardial perfusion imagingTreadmill exerciseElectrocardiographic changesAdverse effectsAdenosine myocardial perfusion imagingSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingIschemic electrocardiographic changesLow-level exerciseMore adverse effectsUnfavorable side effectsSingle photon emissionAdenosine studyAdenosine TcMore patientsMyocardial ischemiaHemodynamic responseStress perfusionSide effectsPerfusion imagingTracer uptakePatientsMPI studiesDetection of Myocardial Ischemia in Patients With Diabetes Mellitus
Wackers FJ, Zaret BL. Detection of Myocardial Ischemia in Patients With Diabetes Mellitus. Circulation 2002, 105: 5-7. PMID: 11772867, DOI: 10.1161/circ.105.1.5.Peer-Reviewed Original Research
2001
Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imaging
2000
Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean restAssociation of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpoint
1999
Can acute rest imaging shorten evaluation in chest pain centers?
Wackers F. Can acute rest imaging shorten evaluation in chest pain centers? Journal Of Nuclear Cardiology 1999, 6: 676-678. PMID: 10608597, DOI: 10.1016/s1071-3581(99)90106-x.Peer-Reviewed Original Research
1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patientsProcedure guideline for myocardial perfusion imaging. Society of Nuclear Medicine.
Strauss H, Miller D, Wittry M, Cerqueira M, Garcia E, Iskandrian A, Schelbert H, Wackers F. Procedure guideline for myocardial perfusion imaging. Society of Nuclear Medicine. Journal Of Nuclear Medicine 1998, 39: 918-23. PMID: 9591601.Peer-Reviewed Original ResearchEffects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease
Jain D, Shaker M, Burg M, Wackers F, Soufer R, Zaret B. Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1314-1322. PMID: 9581726, DOI: 10.1016/s0735-1097(98)00092-8.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionPeripheral vascular resistanceCoronary artery diseaseRate-pressure productStress-induced fallSystolic blood pressureArtery diseaseBlood pressureCardiac outputHeart rateMental stressGroup IHemodynamic variablesAnger recallGroup IIMental stressorsEnd-systolic ventricular elastanceMental stress-induced changesSemisupine bicycle exerciseGroup II patientsComparable increaseDiastolic blood pressureVentricular ejection fractionExercise-induced changesVascular resistanceLimitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ. Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. Journal Of Nuclear Medicine 1998, 39: 417-25. PMID: 9529285.Peer-Reviewed Original ResearchConceptsSingle-vessel stenosisMyocardial blood flowDobutamine stressCoronary stenosisTechnetium-99mBlood flowLeft circumflex artery stenosisCircumflex artery stenosisFlow deficitsSingle coronary stenosisCoronary artery diseaseRate-pressure productRegional myocardial blood flowLeft ventricular pressurePeak dobutamine stressOpen-chest dogsNonischemic flowArtery diseaseArtery stenosisPeak dobutamineSestamibi activitySevere stenosisVentricular pressureSestamibi imagingIschemic zone
1997
Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease
Gradel C, Jain D, Batsford W, Wackers F, Zaret B. Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 379-386. PMID: 9362014, DOI: 10.1016/s1071-3581(97)90029-5.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingSustained ventricular tachycardiaPerfusion defect sizeVentricular tachycardiaElectrophysiological studiesArtery diseaseIndependent predictorsMultivariate analysisChronic coronary artery diseaseLeft ventricular ejection fractionSustained monomorphic ventricular tachycardiaGlobal left ventricular functionVentricular ejection fractionLeft ventricular functionPrevious myocardial infarctionMonomorphic ventricular tachycardiaBest independent predictorSize of ischemiaAdditional ischemiaArrhythmia historyInducible patientsNoninducible patientsSize of scarClinical predictorsImproved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Are separate normal data files required for quantitative pharmacologic stress radionuclide myocardial perfusion imaging?
Wackers F. Are separate normal data files required for quantitative pharmacologic stress radionuclide myocardial perfusion imaging? Journal Of Nuclear Cardiology 1996, 3: s31-s40. PMID: 8989685, DOI: 10.1016/s1071-3581(96)90206-8.Peer-Reviewed Original ResearchDiagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial
Hendel R, Verani M, Miller D, Wackers F, McMahon M, Cerqueira M, Botvinick E, Kvols L, Gerson M. Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial. Journal Of Nuclear Cardiology 1996, 3: 291-300. PMID: 8799247, DOI: 10.1016/s1071-3581(96)90088-4.Peer-Reviewed Original ResearchConceptsMyocardial perfusion agentPerfusion agentMulticenter trialNormalcy ratePhase III multicenter trialCoronary artery diseaseTomographic myocardial perfusionMyocardial perfusion imagingPanel of readersNew myocardial perfusion agentNew perfusion tracerPeak exerciseArtery diseaseThallium scintigraphyPerfusion scintigraphyMyocardial scintigraphyExercise workloadStudy groupLaboratory alterationsMyocardial perfusionThallium-201Perfusion imagingDiagnostic utilityScintigraphyPerfusion studies
1995
Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study.
Soufer R, Dey H, Lawson A, Wackers F, Zaret B. Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study. Journal Of Nuclear Medicine 1995, 36: 180-7. PMID: 7830110.Peer-Reviewed Original ResearchConceptsPlanar thallium scintigraphyCardiac eventsThallium scintigraphyReverse redistributionChronic coronary artery diseasePET viabilityAbnormal regional wall motionPlanar thallium imagesMyocardial Infarction trialPercent of patientsFuture cardiac eventsFuture cardiovascular eventsCoronary artery diseaseFavorable clinical outcomeMyocardial metabolic activityRegional wall motion analysisRegional wall motionPercent of segmentsWall motion analysisPET criteriaCardiovascular eventsReperfusion therapyArtery diseaseClinical outcomesPrognostic value
1994
Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patientsReduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin
Hendel R, Parker M, Wackers F, Rigo P, Lahiri A, Zaret B. Reduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin. Journal Of Nuclear Cardiology 1994, 1: 509-514. PMID: 9420744, DOI: 10.1007/bf02939973.Peer-Reviewed Original Research