2014
Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
McCarthy M, Davey J, Wackers F, Chyun D. Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. The Science Of Diabetes Self-Management And Care 2014, 40: 678-687. PMID: 24942531, PMCID: PMC4169341, DOI: 10.1177/0145721714540055.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDiabetes Mellitus, Type 2Diabetic AngiopathiesExerciseFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMotor ActivityMyocardial IschemiaPeripheral Nervous System DiseasesPredictive Value of TestsPrevalenceProspective StudiesRisk FactorsSedentary BehaviorTime FactorsUnited StatesConceptsAsymptomatic Diabetics (DIAD) studyPhysical inactivityType 2 diabetesDetection of ischemiaDiabetic studyOverweight/obesityPrimary care practicesPhysical activity dataGender-related differencesAsymptomatic patientsAutonomic neuropathySilent ischemiaSecondary data analysisCare practicesType 2Secondary analysisIschemiaDiabetesTime pointsInactivityBaselineWomenMenGender differencesYears
2012
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon S, Wackers F, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH. Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study. Diabetes And Vascular Disease Research 2012, 9: 124-130. PMID: 22228772, DOI: 10.1177/1479164111431470.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesCanadaCardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMass ScreeningMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsUnited StatesConceptsType 2 diabetesMyocardial perfusion imagingCardiovascular outcomesStress myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyBetter cardiac outcomesHigh-risk womenCoronary artery diseaseHigh-risk menDetection of ischemiaMPI abnormalitiesAsymptomatic patientsAsymptomatic menCardiac eventsCardiac outcomesArtery diseaseAsymptomatic womenAbnormal screeningDiabetic studyPerfusion imagingDIAD studyWomenMenDiabetesOutcomes
2008
Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Chia S, Senatore F, Raffel O, Lee H, Wackers F, Jang I. Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. JACC Cardiovascular Interventions 2008, 1: 415-423. PMID: 19463339, DOI: 10.1016/j.jcin.2008.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBenzenesulfonatesBiomarkersCardiovascular AgentsCoronary AngiographyCreatine Kinase, MB FormDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardiumPiperazinesPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentStroke VolumeTime FactorsTomography, Emission-Computed, Single-PhotonTreatment OutcomeTroponin ITroponin TUnited StatesVentricular Function, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeClinical outcomesMyocardial infarctionCardiac biomarkersCoronary interventionCreatine kinaseCK-MBLarge ST-segment elevation myocardial infarctionTroponin TIntracellular calcium modulatorsLarger infarct sizeVentricular ejection fractionCardiac biomarker levelsLeft ventricular functionComposite clinical eventsTime-concentration curveEVOLVE trialLower LVEFAdverse eventsEjection fraction
1999
Can acute rest imaging shorten evaluation in chest pain centers?
Wackers F. Can acute rest imaging shorten evaluation in chest pain centers? Journal Of Nuclear Cardiology 1999, 6: 676-678. PMID: 10608597, DOI: 10.1016/s1071-3581(99)90106-x.Peer-Reviewed Original Research
1996
Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation
Verhoeven P, Lee F, Ramahi T, Franco K, de Leon C, Amatruda J, Gorham N, Mattera J, Wackers F. Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation. Journal Of The American College Of Cardiology 1996, 28: 183-189. PMID: 8752812, DOI: 10.1016/0735-1097(96)00094-0.Peer-Reviewed Original ResearchConceptsCoronary artery vasculopathyOrthotopic cardiac transplantationCardiac transplantationEquilibrium radionuclide angiographyPrognostic valueRadionuclide angiographyClinical variablesNoninvasive testingHuman leukocyte antigen mismatchesStress thallium-201 imagingThallium-201 myocardial perfusion imagingConsecutive transplant recipientsRoutine noninvasive testingStress myocardial imagingCold ischemic timeStress myocardial perfusionThallium-201 imagingTwo-dimensional echocardiographyNoninvasive diagnostic testingMyocardial perfusion imagingOnly significant predictorAntigen mismatchesLate deathsTransplant recipientsIschemic time
1994
Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patientsFetal Responses to Maternal Exercise: Effect on Fetal Breathing and Body Movement
Winn H, Hess O, Goldstein I, Wackers F, Hobbins J. Fetal Responses to Maternal Exercise: Effect on Fetal Breathing and Body Movement. American Journal Of Perinatology 1994, 11: 263-266. PMID: 7945619, DOI: 10.1055/s-2007-994588.Peer-Reviewed Original ResearchConceptsFetal body movementsMaternal heart rateMaternal exerciseFetal breathingHeart rateAge-predicted maximal heart rateMaximal heart rateReal-time ultrasonographyStandardized exercise testBlood pressureBruce protocolFetal responseGestational ageHealthy patientsExercise testFetal activityBody movementsSignificant decreaseBreathingTotal durationPatientsSignificant increaseExercisePregnancyUltrasonography
1993
Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol.
Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol. Journal Of Nuclear Medicine 1993, 34: 1254-9. PMID: 8326381.Peer-Reviewed Original ResearchConceptsOrgan ratiosGastrointestinal tractRest imagesImaging protocolSymptom-limited treadmill exerciseDecay-corrected countsLeft anterior oblique viewStress imagesAnterior oblique viewPortion of liverOptimal imaging protocolMyocardial perfusion imaging agentPeak exerciseTreadmill exerciseClinical trialsTechnetium-99mRadiotracer injectionMyocardial perfusionTetrofosmin imagesGallbladderPhase IEntire heartLiverTractOblique view
1991
Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest
Kayden D, Sigal S, Soufer R, Mattera J, Zaret B, Wackers F. Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. Journal Of The American College Of Cardiology 1991, 18: 1480-1486. PMID: 1939949, DOI: 10.1016/0735-1097(91)90678-3.Peer-Reviewed Original ResearchConceptsInjection of thalliumRedistribution imagesDefect reversibilityThallium-201 reinjectionThallium-201 defectsLate redistribution imagingPoor quality studiesDiagnostic informationClinical variablesRedistribution imagingThallium defectsThallium imagesMyocardial viabilityReversible defectsStress imagingThallium-201PatientsBetter diagnostic informationStress testingExercisePresent studyQuality studiesInjectionLate redistributionReinjectionAdenosine or dipyridamole: Which is preferred for myocardial perfusion imaging?
Wackers F. Adenosine or dipyridamole: Which is preferred for myocardial perfusion imaging? Journal Of The American College Of Cardiology 1991, 17: 1295-1296. PMID: 2016446, DOI: 10.1016/s0735-1097(10)80138-x.Peer-Reviewed Original Research
1990
Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction.
Pellikka P, Behrenbeck T, Verani M, Mahmarian J, Wackers F, Gibbons R. Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction. Journal Of Nuclear Medicine 1990, 31: 1269-75. PMID: 2143527.Peer-Reviewed Original ResearchConceptsReperfusion therapyMyocardial infarctionTc-sestamibiAcute reperfusion therapyFirst myocardial infarctionSuccessful reperfusionTomographic myocardial perfusion imagesSerial changesHypoperfused myocardiumMean decreaseFinal studyMyocardial perfusionPatientsSignificant improvementMyocardial perfusion imagesSecond studyTherapyPerfusion imagesReperfusionInfarctionPerfusionFurther decreaseHrTomographic imagingImagingComparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial.
Rogers W, Baim D, Gore J, Brown B, Roberts R, Williams D, Chesebro J, Babb J, Sheehan F, Wackers F. Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. Circulation 1990, 81: 1457-1476. PMID: 2110033, DOI: 10.1161/01.cir.81.5.1457.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCombined Modality TherapyCoronary AngiographyCoronary Artery BypassExercise TestFemaleHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyRandomized Controlled Trials as TopicStroke VolumeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorConceptsCoronary artery bypass graft surgeryPercutaneous transluminal coronary angioplastyInvasive strategy groupConservative-strategy groupAcute myocardial infarctionTreatment groupsPrimary study end pointResidual infarct artery stenosisArtery bypass graft surgeryPatent infarct-related arteryImmediate invasive strategyPredischarge exercise testingSimilar cumulative ratesBypass graft surgeryStudy end pointInfarct-related arteryTransluminal coronary angioplastyVentricular ejection fractionInitial management strategyLong-term outcomesConservative strategyStrategy groupTissue-type plasminogen activatorNonfatal reinfarctionGraft surgery
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201Early image acquisition after administration of indium-111 platelets in clinically suspected deep venous thrombosis
Farlow D, Ezekowitz M, Rao S, Martinez C, Denny D, Morse S, Decho J, Wackers F, Strauss E. Early image acquisition after administration of indium-111 platelets in clinically suspected deep venous thrombosis. The American Journal Of Cardiology 1989, 64: 363-368. PMID: 2502903, DOI: 10.1016/0002-9149(89)90536-5.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisVenous thrombosisPlatelet scintigraphyEarly imagingAsymptomatic high-risk patientsSymptomatic deep venous thrombosisAcute deep venous thrombosisIndium-111 platelet scintigraphyHigh-risk patientsIndium-111 plateletsEarly image acquisitionIndium-111 oxinePlatelet injectionPlatelet scanAnticoagulated patientsSymptomatic patientsContrast venographyRecent onsetTimely institutionIntravenous administrationScintigraphyBlinded observersPatientsThrombosisLow sensitivityVariables predictive of good functional outcome following thrombolytic therapy in the Thrombolysis in Myocardial Infarction phase II (TIMI II) pilot study
Rogers W, Bourge R, Papapietro S, Wackers F, Zaret B, Forman S, Dodge H, Robertson T, Passamani E, Braunwald E, Investigators F. Variables predictive of good functional outcome following thrombolytic therapy in the Thrombolysis in Myocardial Infarction phase II (TIMI II) pilot study. The American Journal Of Cardiology 1989, 63: 503-512. PMID: 2521976, DOI: 10.1016/0002-9149(89)90889-8.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGood functional outcomeAngioplasty groupEjection fractionPeak exerciseHospital dischargeFunctional outcomePilot studyMyocardial Infarction Phase II (TIMI II) studyIntravenous recombinant tissue plasminogen activatorLeft ventricular ejection fractionPhase II pilot studyRecombinant tissue plasminogen activatorPhase II studyGood ventricular functionHours of onsetPercutaneous transluminal angioplastyRt-PA infusionVentricular ejection fractionObservational pilot studyST-segment elevationEquilibrium radionuclide ventriculographyGated equilibrium radionuclide ventriculographyAbsence of arrhythmiasTissue plasminogen activator
1987
Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography
Schwartz R, McKenzie W, Alexander J, Sager P, D'Souza A, Manatunga A, Schwartz P, Berger H, Setaro J, Surkin L, Wackers F, Zaret B. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography. The American Journal Of Medicine 1987, 82: 1109-1118. PMID: 3605130, DOI: 10.1016/0002-9343(87)90212-9.Peer-Reviewed Original ResearchConceptsClinical congestive heart failureCongestive heart failureVentricular ejection fractionAbsolute left ventricular ejection fractionLeft ventricular ejection fractionHeart failureEjection fractionDoxorubicin therapyMild congestive heart failureClinical predictor variablesDiscontinuation of doxorubicinTotal cumulative dosageHigh-risk patientsHigh-risk subsetMajority of patientsHigh cumulative doseCommunity hospital settingProportional hazards regressionSeven-year experienceCommunity hospital environmentSerial radionuclideLast followVentricular dysfunctionClinical outcomesRoutine therapy
1985
Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain
Wackers F, Russo D, Russo D, Clements J. Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain. Journal Of The American College Of Cardiology 1985, 6: 27-30. PMID: 3159779, DOI: 10.1016/s0735-1097(85)80247-3.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseThallium-201 stress scintigraphyArtery diseaseStress scintigraphyPretest likelihoodCardiac eventsChest painPrognostic significanceQuantitative thallium-201 scintigraphyChest pain syndromeThallium-201 scintigraphyHigh pretest likelihoodLow pretest likelihoodBasis of symptomsAnginal complaintsMean followPain syndromeExcellent prognosisNormal findingsConsecutive seriesStress electrocardiographyNormal studiesPatientsScintigraphyDiseaseQuantitative planar thallium-201 stress scintigraphy: A critical evaluation of the method
Wackers F, Fetterman R, Mattera J, Clements J. Quantitative planar thallium-201 stress scintigraphy: A critical evaluation of the method. Seminars In Nuclear Medicine 1985, 15: 46-66. PMID: 3885400, DOI: 10.1016/s0001-2998(85)80043-x.Peer-Reviewed Original Research
1976
Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction.
Wackers F, Lie K, Becker A, Durrer D, Wellens H. Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction. Heart 1976, 38: 906. PMID: 971375, PMCID: PMC483104, DOI: 10.1136/hrt.38.9.906.Peer-Reviewed Original ResearchConceptsCongestive heart failureAcute myocardial infarctionHeart failureCardiogenic shockCoronary arteryMyocardial infarctionSevere diseaseFatal congestive heart failureRefractory congestive heart failurePump failureThree-vessel diseaseCoronary bypass surgeryRight coronary arteryCoronary artery diseaseLeft circumflex arteryCent narrowingBypass surgeryArtery diseaseLeft anteriorCircumflex arteryPathological findingsSevere narrowingEqual incidenceAnatomical findingsPatientsValue and Limitations of Thallium-201 Scintigraphy in the Acute Phase of Myocardial Infarction
Wackers F, Sokole E, Samson G, Schoot J, Lie K, Liem K, Wellens H. Value and Limitations of Thallium-201 Scintigraphy in the Acute Phase of Myocardial Infarction. New England Journal Of Medicine 1976, 295: 1-5. PMID: 1272283, DOI: 10.1056/nejm197607012950101.Peer-Reviewed Original Research