2020
George A. Beller, MD (Born 1940)
Wackers FJT, Corner T. George A. Beller, MD (Born 1940). Journal Of Nuclear Cardiology 2020, 27: 723-725. PMID: 32367225, DOI: 10.1007/s12350-020-02115-2.Peer-Reviewed Original Research
1997
Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease
Gradel C, Jain D, Batsford W, Wackers F, Zaret B. Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 379-386. PMID: 9362014, DOI: 10.1016/s1071-3581(97)90029-5.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingSustained ventricular tachycardiaPerfusion defect sizeVentricular tachycardiaElectrophysiological studiesArtery diseaseIndependent predictorsMultivariate analysisChronic coronary artery diseaseLeft ventricular ejection fractionSustained monomorphic ventricular tachycardiaGlobal left ventricular functionVentricular ejection fractionLeft ventricular functionPrevious myocardial infarctionMonomorphic ventricular tachycardiaBest independent predictorSize of ischemiaAdditional ischemiaArrhythmia historyInducible patientsNoninducible patientsSize of scarClinical predictorsRelevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri.
Jain D, Thompson B, Wackers F, Zaret B, Investigators F. Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri. Journal Of The American College Of Cardiology 1997, 30: 421-429. PMID: 9247514, DOI: 10.1016/s0735-1097(97)00164-2.Peer-Reviewed Original ResearchConceptsLung/heart ratioAdverse cardiac eventsNon-Q-wave myocardial infarctionCoronary artery diseaseCardiac eventsPerfusion abnormalitiesMyocardial infarctionUnstable anginaArtery diseaseStress-induced left ventricular dysfunctionHigher cardiac event rateLeft ventricular ejection fractionAggressive interventional managementHigher revascularization rateLung thallium uptakeCardiac event rateTotal exercise timeFrequency of anginaLeft ventricular dysfunctionST-segment depressionLower exercise capacityVentricular ejection fractionPrevious myocardial infarctionMyocardial perfusion abnormalitiesNormal myocardial perfusionImproved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Quantitative comparison of planar and SPECT normal data files of thallium-201, technetium-99m-sestamibi, technetium-99m-tetrofosmin and technetium-99m-furifosmin.
Naruse H, Daher E, Sinusas A, Jain D, Natale D, Mattera J, Makuch R, Wackers FJ. Quantitative comparison of planar and SPECT normal data files of thallium-201, technetium-99m-sestamibi, technetium-99m-tetrofosmin and technetium-99m-furifosmin. Journal Of Nuclear Medicine 1996, 37: 1783-8. PMID: 8917175.Peer-Reviewed Original ResearchQuantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects
Siebelink H, Natale D, Sinusas A, Wackers F. Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects. Journal Of Nuclear Cardiology 1996, 3: 483-493. PMID: 8989673, DOI: 10.1016/s1071-3581(96)90058-6.Peer-Reviewed Original ResearchConceptsDefect reversibilitySingle photon emissionDual-isotope SPECTNormal databaseStress-rest single-photon emissionTechnetium 99m-labeled sestamibiStress-induced myocardial ischemiaStress single-photon emissionPerfusion defect reversibilityPrior myocardial infarctionDefect sizeRest/stressSingle-isotope imagingMyocardial infarctionThallium SPECTMyocardial ischemiaIndividual patientsMyocardial perfusionThallium-201PatientsSestamibiCircumferential count profilesTomographic imagingImaging protocolDual-isotope imagingDiagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial
Hendel R, Verani M, Miller D, Wackers F, McMahon M, Cerqueira M, Botvinick E, Kvols L, Gerson M. Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial. Journal Of Nuclear Cardiology 1996, 3: 291-300. PMID: 8799247, DOI: 10.1016/s1071-3581(96)90088-4.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseExercise TestFemaleFuransHeartHumansMaleMiddle AgedOrganotechnetium CompoundsRadionuclide ImagingThallium RadioisotopesConceptsMyocardial perfusion agentPerfusion agentMulticenter trialNormalcy ratePhase III multicenter trialCoronary artery diseaseTomographic myocardial perfusionMyocardial perfusion imagingPanel of readersNew myocardial perfusion agentNew perfusion tracerPeak exerciseArtery diseaseThallium scintigraphyPerfusion scintigraphyMyocardial scintigraphyExercise workloadStudy groupLaboratory alterationsMyocardial perfusionThallium-201Perfusion imagingDiagnostic utilityScintigraphyPerfusion studiesPrognostic value of noninvasive testing one year after orthotopic cardiac transplantation
Verhoeven P, Lee F, Ramahi T, Franco K, de Leon C, Amatruda J, Gorham N, Mattera J, Wackers F. Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation. Journal Of The American College Of Cardiology 1996, 28: 183-189. PMID: 8752812, DOI: 10.1016/0735-1097(96)00094-0.Peer-Reviewed Original ResearchConceptsCoronary artery vasculopathyOrthotopic cardiac transplantationCardiac transplantationEquilibrium radionuclide angiographyPrognostic valueRadionuclide angiographyClinical variablesNoninvasive testingHuman leukocyte antigen mismatchesStress thallium-201 imagingThallium-201 myocardial perfusion imagingConsecutive transplant recipientsRoutine noninvasive testingStress myocardial imagingCold ischemic timeStress myocardial perfusionThallium-201 imagingTwo-dimensional echocardiographyNoninvasive diagnostic testingMyocardial perfusion imagingOnly significant predictorAntigen mismatchesLate deathsTransplant recipientsIschemic timeRadionuclide detection of myocardial ischemia and myocardial viability: Is the glass half empty or half full?
Wackers F. Radionuclide detection of myocardial ischemia and myocardial viability: Is the glass half empty or half full? Journal Of The American College Of Cardiology 1996, 27: 1598-1600. PMID: 8636542, DOI: 10.1016/0735-1097(96)00101-5.Peer-Reviewed Original Research
1995
Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome
Fleisher L, Rosenbaum S, Nelson A, Jain D, Wackers F, Zaret B. Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome. Anesthesiology 1995, 83: 906-917.. PMID: 7486176, DOI: 10.1097/00000542-199511000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDipyridamoleElectrocardiography, AmbulatoryFemaleHeart DiseasesHumansIntraoperative ComplicationsMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsPreoperative CarePrognosisProspective StudiesRadionuclide AngiographySensitivity and SpecificitySurvival AnalysisThallium RadioisotopesVasodilator AgentsConceptsPerioperative cardiac eventsPredictive valueDipyridamole thalliumCardiac eventsPreoperative dipyridamole thallium imagingLong-term cardiac survivalGreatest likelihood ratioNoncardiac surgery patientsPerioperative cardiac morbidityDipyridamole-thallium imagingLong-term mortalityLong-term prognosisAmbulatory electrocardiographic monitoringShort-term outcomesLong-term outcomesLikelihood ratioPositive predictive valueLog-rank statisticsNuclear cardiology laboratoryCardiac morbidityNoncardiac surgerySurgery patientsThallium imagingCardiac survivalElectrocardiographic monitoringRelationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study.
Soufer R, Dey H, Lawson A, Wackers F, Zaret B. Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study. Journal Of Nuclear Medicine 1995, 36: 180-7. PMID: 7830110.Peer-Reviewed Original ResearchConceptsPlanar thallium scintigraphyCardiac eventsThallium scintigraphyReverse redistributionChronic coronary artery diseasePET viabilityAbnormal regional wall motionPlanar thallium imagesMyocardial Infarction trialPercent of patientsFuture cardiac eventsFuture cardiovascular eventsCoronary artery diseaseFavorable clinical outcomeMyocardial metabolic activityRegional wall motion analysisRegional wall motionPercent of segmentsWall motion analysisPET criteriaCardiovascular eventsReperfusion therapyArtery diseaseClinical outcomesPrognostic valueMyocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injectionClinical investigative perspective
Wackers F. Clinical investigative perspective. Journal Of Nuclear Cardiology 1995, 2: 75-77. PMID: 9420766, DOI: 10.1016/s1071-3581(05)80012-1.Peer-Reviewed Original ResearchConceptsClinical useExciting new agentPhase III studyNew imaging agentWidespread clinical useIII studyNew agentsClinical protocolsClinical investigatorsNew radiopharmaceuticalsExperienced investigatorsImaging agentCliniciansAcademic investigatorsInvestigatorsFinal approvalExciting new discoveriesScientific evaluationRadiopharmaceutical researchAgentsImaging methodology
1994
Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina
Bodenheimer M, Wackers F, Schwartz R, Brown M, Group T. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1994, 74: 1196-1200. PMID: 7977089, DOI: 10.1016/0002-9149(94)90547-9.Peer-Reviewed Original ResearchMeSH KeywordsAngina, UnstableExercise TestFemaleHumansMaleMiddle AgedMyocardial InfarctionPrognosisRadionuclide ImagingSurvival AnalysisThallium RadioisotopesConceptsNonfatal infarctionCardiac eventsUnstable anginaCardiac deathMyocardial infarctionReversible defectsExercise thallium studiesNonfatal myocardial infarctionAcute coronary eventsLarge prospective studiesAcute cardiac eventsKaplan-Meier curvesAcute myocardial infarctionLog-rank statisticsCoronary eventsExercise thalliumPatient 1Prognostic significanceProspective studyMyocardial ischemiaThallium studiesThallium testThallium imagesInfarctionPatientsLimited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patientsReduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin
Hendel R, Parker M, Wackers F, Rigo P, Lahiri A, Zaret B. Reduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin. Journal Of Nuclear Cardiology 1994, 1: 509-514. PMID: 9420744, DOI: 10.1007/bf02939973.Peer-Reviewed Original ResearchRadionuclide Evaluation of Coronary Artery Disease in the 1990S Choosing The Best Stress, Best Tracer, Best Technique
Wackers F. Radionuclide Evaluation of Coronary Artery Disease in the 1990S Choosing The Best Stress, Best Tracer, Best Technique. Cardiology Clinics 1994, 12: 385-389. PMID: 8033184, DOI: 10.1016/s0733-8651(18)30117-6.Peer-Reviewed Original ResearchThe maze of myocardial perfusion imaging protocols in 1994
Wackers F. The maze of myocardial perfusion imaging protocols in 1994. Journal Of Nuclear Cardiology 1994, 1: 180-188. PMID: 9420685, DOI: 10.1007/bf02984090.Peer-Reviewed Original ResearchMeSH KeywordsHeartHumansOrganophosphorus CompoundsOrganotechnetium CompoundsOximesRadionuclide ImagingTechnetium Tc 99m SestamibiThallium Radioisotopes
1993
A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy
Mortelmans L, Nuyts J, Scheys I, Wackers F, Lesaffre E, Brzostek T, De Roo M, De Geest H, Suetens P, Verbruggen A, Van de Werf F. A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy. European Journal Of Nuclear Medicine And Molecular Imaging 1993, 20: 1193-1200. PMID: 8299655, DOI: 10.1007/bf00171018.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansMethodsMyocardial InfarctionTechnetium Tc 99m SestamibiThallium RadioisotopesThrombolytic TherapyTomography, Emission-Computed, Single-PhotonConceptsEnzymatic infarct sizePerfusion defectsThrombolytic therapyVentricular functionInfarct sizeInfarct-related vesselLarge perfusion defectsThallium-201 chloridePost-infarct patientsPerfusion defect sizeGlobal ventricular functionRegional ventricular functionPerfusion tomographyContrast angiographyPatientsBeneficial effectsTherapyMyocardial perfusion tomogramsSignificant differencesPlanar quantificationValve planeDetection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA 1993, 269: 2379-85. PMID: 8479063, DOI: 10.1001/jama.269.18.2379.Peer-Reviewed Original ResearchConceptsAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsNon-invasive testingPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsStable patientsExercise durationLung uptake