Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig
Bia F, Lucia H, Bia M, Vine W, Tuttle A. Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig. Intervirology 1985, 24: 154-165. PMID: 2999030, DOI: 10.1159/000149635.Peer-Reviewed Original ResearchConceptsPrimary cytomegalovirus infectionGuinea pigsCytomegalovirus infectionPrimary CMV infectionEffect of cyclosporinePresence of CMVGuinea pig CMVGuinea pig modelInternal organsHartley guinea pigsTotal body weightUntreated controlsCMV isolationOral CsACMV infectionCsA administrationLymphocyte valuesLymphocytes/Inflammatory responseMean changeViral inclusionsBody weightPig modelDay 0CMVPulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia
Miller S, Bia F, Coleman D, Lucia H, Young K, Root R. Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia. Infection And Immunity 1985, 47: 211-216. PMID: 2981196, PMCID: PMC261498, DOI: 10.1128/iai.47.1.211-216.1985.Peer-Reviewed Original ResearchConceptsPulmonary macrophagesInterstitial pneumoniaCytomegalovirus interstitial pneumoniaMacrophage oxidative functionTissue culture infective dosesH2O2 releaseCMV interstitial pneumoniaPulmonary macrophage functionGuinea pig CMVSalivary gland suspensionsBuffy coat cellsBone marrow cellsPhorbol myristate acetateO2 consumptionCMV pneumoniaPulmonary granulocytesCytomegalovirus infectionVariety of pathogensWhole lungControl animalsPulmonary lavageUninfected controlsMacrophage functionVirus isolationDay 7