2022
Randomization for the susceptibility effect of an infectious disease intervention
Eck DJ, Morozova O, Crawford FW. Randomization for the susceptibility effect of an infectious disease intervention. Journal Of Mathematical Biology 2022, 85: 37. PMID: 36127558, PMCID: PMC9809173, DOI: 10.1007/s00285-022-01801-8.Peer-Reviewed Original ResearchConceptsInfectious disease interventionsInfection outcomesInfection riskDisease interventionDirect effectRandomized trialsTreatment allocationInfectious disease transmissionStudy subjectsHarmful treatmentPathogen of interestInterventionOutcomesTreatmentRandomization designVaccineDisease transmissionSusceptibility effectsTrialsRiskRandomizationInfectionIndividualsSARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021
Tran TN, Wikle NB, Yang F, Inam H, Leighow S, Gentilesco B, Chan P, Albert E, Strong ER, Pritchard JR, Hanage WP, Hanks EM, Crawford FW, Boni MF. SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021. JAMA Network Open 2022, 5: e2214171. PMID: 35616938, PMCID: PMC9136627, DOI: 10.1001/jamanetworkopen.2022.14171.Peer-Reviewed Original ResearchConceptsHigh vaccine coveragePopulation immunityPublic health agenciesVaccine coverageVaccination campaignMAIN OUTCOMECOVID-19 positive test resultsSARS-CoV-2 attack ratesIntensive care unit occupancyHealth agenciesLarge epidemic waveProportion of vaccinesAttack rateObservational case seriesPopulation-level immunitySARS-CoV-2Median ageCase seriesCOVID-19 casesPercentage of individualsVaccination planningDelta variantOngoing epidemicPandemic settingVaccineVaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 2022, 375: eabl4292. PMID: 35084937, PMCID: PMC9261115, DOI: 10.1126/science.abl4292.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Effectiveness of vaccinesEffectiveness of vaccinationTotal vaccine effectivenessSARS-CoV-2Household contactsSecond doseCoronavirus 2Household transmissionDelta variantDay 10VaccinationBNT162b2COVID-19InfectionChain binomial modelVaccineDoseImmunity
2015
Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Pitzer VE, Bilcke J, Heylen E, Crawford FW, Callens M, De Smet F, Van Ranst M, Zeller M, Matthijnssens J. Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium? Scientific Reports 2015, 5: 18585. PMID: 26687288, PMCID: PMC4685644, DOI: 10.1038/srep18585.Peer-Reviewed Original ResearchConceptsVaccine introductionStrain-specific vaccine effectivenessVaccine-derived immunityRotavirus vaccine introductionVaccine-induced immunityAbsence of vaccinationRotavirus populationLarge-scale vaccinationDistribution of genotypesRotavirus gastroenteritisVaccine effectivenessHomotypic strainHospitalization dataPredominant rotavirusStrain replacementVaccinationVaccineImmunityInfectionViral populationsPopulationGastroenteritisYearsIncidenceRotavirus