2024
BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans.
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAlgorithmsBone DensityFemaleHumansMaleNatural Language ProcessingConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracy
2023
Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol use
2021
Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT
Jin S, Li M, Wang Q, Zeng X, Xia W, Yu W, Guan W, Hsieh E. Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT. Arthritis Research & Therapy 2021, 23: 127. PMID: 33894786, PMCID: PMC8067377, DOI: 10.1186/s13075-021-02503-0.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonArthritis, RheumatoidBone DensityChinaCross-Sectional StudiesFemaleHumansRadiusTibiaConceptsBone mineral densityRheumatoid arthritisRisk of fractureCross-sectional studyMineral densityFragility fracturesDistal radiusHealthy controlsBone microarchitectureBone strengthHigh-resolution peripheral quantitative computed tomographySex-matched healthy controlsPeripheral quantitative computed tomographyDual-energy X-ray absorptiometryVolumetric bone mineral densityFemale reproductive factorsRA-related characteristicsThoracolumbar X-rayTraditional risk factorsQuantitative computed tomographyX-ray absorptiometryCortical bone thicknessThin cortical boneGroup of ageChinese RegistryLong-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals
Guan W, Pan W, Yu W, Cao W, Lin Q, Zhang Z, Song X, Li Y, Tian J, Xu Y, Li T, Hsieh E. Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals. Archives Of Osteoporosis 2021, 16: 41. PMID: 33624129, PMCID: PMC9675940, DOI: 10.1007/s11657-021-00890-0.Peer-Reviewed Original ResearchConceptsTrabecular bone scoreBone mineral densityTH bone mineral densityNormal bone mineral densityAntiretroviral therapyBone scoreART initiationFemoral neckMineral densityBone microarchitectureTotal hip (TH) BMDLumbar spine (LS) BMDBone mineral density changesFN bone mineral densityLarge tertiary care hospitalRetrospective chart reviewTertiary care hospitalMineral density changesMean percent decreaseResultsFour hundred fiftyPercent decreaseAdult PWHChart reviewCare hospitalBMD changesComparison of Differences in Bone Mineral Density Measurement With 3 Hologic Dual-Energy X-Ray Absorptiometry Scan Modes
Yu W, Zhang Z, Pan W, Guan W, Lin Q, Xia W, Li T, Hsieh E. Comparison of Differences in Bone Mineral Density Measurement With 3 Hologic Dual-Energy X-Ray Absorptiometry Scan Modes. Journal Of Clinical Densitometry 2021, 24: 645-650. PMID: 33504451, PMCID: PMC9674387, DOI: 10.1016/j.jocd.2021.01.003.Peer-Reviewed Original Research
2020
Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy
Guo F, Song X, Li Y, Guan W, Pan W, Yu W, Li T, Hsieh E. Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy. Osteoporosis International 2020, 32: 321-332. PMID: 32803316, PMCID: PMC9509525, DOI: 10.1007/s00198-020-05584-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAsiaBone DensityChinaHIV InfectionsHumansMaleMiddle AgedRetrospective StudiesConceptsTenofovir disoproxil fumarateLong-term clinical managementBone mineral density lossMineral density lossAntiretroviral therapyDisoproxil fumarateClinical managementRisk factorsGreater bone mineral density lossInitiation of TDFDual-energy x-ray absorptiometry testingHIV-specific parametersNon-TDF groupUndetectable viral loadOutpatient HIV clinicRelated risk factorsLarge tertiary hospitalBone mineral densityDensity lossAntiretroviral initiationTDF groupWeek 96HIV clinicWeek 48HIV diagnosisAge‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
Yu F, Xu Y, Hou Y, Lin Y, Jiajue R, Jiang Y, Wang O, Li M, Xing X, Zhang L, Qin L, Hsieh E, Xia W. Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population. Journal Of Bone And Mineral Research 2020, 35: 2159-2170. PMID: 32564403, PMCID: PMC9719438, DOI: 10.1002/jbmr.4116.Peer-Reviewed Original ResearchConceptsHigh-resolution peripheral quantitative computed tomographyPeripheral quantitative computed tomographyVolumetric bone mineral densityCortical bone lossHR-pQCT parametersBone mineral densityHealthy Chinese menNormative reference rangesQuantitative computed tomographyHR-pQCT scansLatest-generation scannersYears of ageHR-pQCT measuresFracture risk assessmentBone strength parametersDifferent disease statesBone lossCortical porosityMineral densityBone microarchitectureEarly diagnosisComputed tomographyChinese menReference rangeNutritional status
2019
Impact of reference point selection on DXA-based measurement of forearm bone mineral density
Yu W, Ying Q, Guan W, Lin Q, Zhang Z, Chen J, Engelke K, Hsieh E. Impact of reference point selection on DXA-based measurement of forearm bone mineral density. Archives Of Osteoporosis 2019, 14: 107. PMID: 31707587, PMCID: PMC9721067, DOI: 10.1007/s11657-019-0658-2.Peer-Reviewed Original Research
2018
Continued Interest and Controversy: Vitamin D in HIV
Hsieh E, Yin MT. Continued Interest and Controversy: Vitamin D in HIV. Current HIV/AIDS Reports 2018, 15: 199-211. PMID: 29713871, PMCID: PMC6003869, DOI: 10.1007/s11904-018-0401-4.BooksConceptsVitD deficiencyVitD supplementationExtra-skeletal outcomesSetting of HIVSubgroup of HIVBone mineral densityRecent FindingsRecent studiesART regimensD deficiencyClinical outcomesPoor outcomeSummaryFurther researchVitamin DChronic diseasesClinical trialsDifferent demographic strataMineral densityClinical roleHIVGreater riskDemographic strataSignificant heterogeneityOutcomesRiskSupplementationVertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps
Hsieh E, Wang Q, Zhang R, Niu X, Xia W, Fraenkel L, Insogna KL, Li J, Smith JS, Zhou C, Qiao YL, Zhang P. Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BMC Cancer 2018, 18: 104. PMID: 29378534, PMCID: PMC5789645, DOI: 10.1186/s12885-018-4014-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsVertebral fracturesCancer survivorsCross-sectional studyBreast cancerBone lossCancer treatment-induced bone lossHealthy community-dwelling postmenopausal womenProgesterone receptor-positive breast cancerHealth servicesBreast cancer survivor cohortCommunity-dwelling postmenopausal womenFracture-related risk factorsPeking Vertebral Fracture StudyTreatment-induced bone lossReceptor-positive breast cancerChinese breast cancer survivorsCancer survivor cohortLarge cancer hospitalThoracolumbar X-rayVitamin D supplementsPrevalent vertebral fracturesBone density scanInitiation of treatmentAdjusted odds ratio