2023
Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families
Lima M, Saraiva L, Ramos V, Oliveira M, Costa D, Disorders B, Fernandez T, Crowley J, Storch E, Shavitt R, Miguel E, Cappi C. Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families. Psychiatry Research 2023, 331: 115627. PMID: 38113811, PMCID: PMC11129832, DOI: 10.1016/j.psychres.2023.115627.Peer-Reviewed Original ResearchComparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
Hoffmann M, Pine D, Georgiades K, Szatmari P, Miguel E, Pan P, Gadelha A, Rohde L, Merikangas K, Milham M, Satterthwaite T, Salum G. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil. The Lancet Global Health 2023, 12: e79-e89. PMID: 37980914, PMCID: PMC10716620, DOI: 10.1016/s2214-109x(23)00462-x.Peer-Reviewed Original ResearchGamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatientsBrazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment
de Oliveira M, de Barros P, de Mathis M, Boavista R, Chacon P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, Miguel E, da Silva R, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment. Brazilian Journal Of Psychiatry 2023, 45: 146-161. PMID: 36749887, PMCID: PMC10154009, DOI: 10.47626/1516-4446-2022-2891.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsAdult obsessive-compulsive disorderObsessive-compulsive disorderPharmacological treatmentReuptake inhibitorsEvidence-based pharmacological interventionsFirst-line pharmacological treatmentAmerican Psychiatric Association guidelinesEvidence-based pharmacological treatmentFirst-line treatmentNorepinephrine reuptake inhibitorsPrimary outcome measureSerotonin reuptake inhibitorsGlutamate-modulating agentsHigh-quality evidenceAmerican Heart AssociationLevel of evidenceTreatment of OCDBrazilian Research ConsortiumAdult patientsHeart AssociationTolerable dosesAssociation guidelinesTreatment recommendationsPharmacological interventionsIdentifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample
Cunha G, Caye A, Pan P, Fisher H, Pereira R, Ziebold C, Bressan R, Miguel E, Salum G, Rohde L, Kohrt B, Mondelli V, Kieling C, Gadelha A. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Brazilian Journal Of Psychiatry 2023, 45: 242-248. PMID: 37126861, PMCID: PMC10288471, DOI: 10.1590/1516-4446-2022-2775.Peer-Reviewed Original Research
2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisolChildhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, de Jesus Mari J, Gadelha A. Childhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil. Scientific Reports 2022, 12: 13381. PMID: 35927553, PMCID: PMC9352677, DOI: 10.1038/s41598-022-13975-8.Peer-Reviewed Original ResearchConceptsCriminal convictionsImportance of povertyPublic problemsPopulation attributable risk fractionBrazilian youthGreat social impactYoung peopleModifiable risk factorsPovertySocial impactCrimeConvictionRisk factorsSubsequent criminal convictionsEradication interventionsChildren's exposureMiddle-income countriesFamily exposureYouthMultiple modifiable risk factorsOnly modifiable risk factorAttributable risk fractionSignificant risk factorsMajor public problemCohort studyChronic lung lesions in COVID-19 survivors: predictive clinical model
Carvalho C, Chate R, Sawamura M, Garcia M, Lamas C, Cardenas D, Lima D, Scudeller P, Salge J, Nomura C, Gutierrez M, Araújo A, Segurado A, Montal A, Miethke-Morais A, Levin A, Perondi B, Guedes B, Carmo C, Lázari C, Antonio C, Tanaka C, Leite C, Gomes C, Utiyama E, Burdmann E, Bonfá E, Kallas E, Sabino E, Miguel E, Pinna F, Kawano F, Busatto G, Cerri G, Fonseca G, Souza H, Marcilio I, Rios I, Hallak J, Krieger J, Ferreira J, Marchini J, Oliveira L, Harima L, Batisttella L, Yu L, Castro L, Rocha M, Magri M, Mancini M, de Jesus M, Corrêa M, Francisco M, Rossi M, Silva M, Imamura M, Oliveira M, Gouveia N, Forlenza O, Lotufo P, Bento R, Nitrini R, Damiano R, Chammas R, Francisco R, Fusco S, Barros-Filho T, Mauad T, Guimarães T, Avelino-Silva T, Filho W. Chronic lung lesions in COVID-19 survivors: predictive clinical model. BMJ Open 2022, 12: e059110. PMID: 35697456, PMCID: PMC9195157, DOI: 10.1136/bmjopen-2021-059110.Peer-Reviewed Original ResearchConceptsChest X-rayPredictive clinical modelCOVID-19 survivorsLung lesionsClinical modelLung lesion detectionMMRC scaleChest CTMedical Research Council dyspnoea scaleSARS-CoV-2-infected patientsSARS-CoV-2 infectionCOVID-19 sequelaeSignificant pulmonary abnormalitiesProspective cohort studyGround-glass opacitiesCOVID-19 infectionChronic lung lesionsLesion detectionDyspnoea scalePulmonary involvementTraction bronchiectasisCohort studyCXR findingsHospital dischargePulmonary function
2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung peopleCOMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned
Fukuti P, Uchôa C, Mazzoco M, da Cruz I, Echegaray M, de Castro Humes E, Silveira J, Di Santi T, Miguel E, Corchs F, program C, Fatori D, Campello G, de Oliveira G, Argolo F, de M. Ferreira F, Machado G, Argeu A, de Oliveira G, de Pádua Serafim A, de Lima Siqueira L, de Rossi L, Rios I, de Oliveira T, Antoniazzi L, Gagliotti D, Abelama E, de Oliveira P, Correia A, Gonçalves L, Tortato L, Busato W, Guimarães-Fernandes F, Alves M, Leite O, de Campos Lindenberg Schoueri P, de Assis Roque M, Merlin S, Boer G, Sallet P, Malbergier A, Spedo M, Kamitsuji C, de Faria E, de Godoy Moreira M, Kaufman A, Abdo C, de Tubino Scanavino M, Lancman S, Tavares H, Polanczyk G, Brunoni A, Forlenza O, de Barros-Filho T. COMVC-19: A Program to protect healthcare workers' mental health during the COVID-19 Pandemic. What we have learned. Clinics 2021, 76: e2631. PMID: 34817044, PMCID: PMC8579850, DOI: 10.6061/clinics/2021/e2631.Peer-Reviewed Original ResearchConceptsNursing staffHospital das Clinicas da FaculdadeHealthcare workers' mental healthMedicina da Universidade de São PauloMental healthCOVID-19 patientsMental health impairmentMental health treatmentCOVID-19 pandemicMental health programsWorkers' mental healthCommon diagnosisPreventive actionsSleep disturbancesMood disordersPsychiatric evaluationMultimodal interventionHealth treatmentDepression symptomsHealth programsPublic hospitalsHealth impairmentSymptomsMobile phone appMost participantsThe impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil
Hoffmann M, McDaid D, Salum G, Silva-Ribeiro W, Ziebold C, King D, Gadelha A, Miguel E, de Jesus Mari J, Rohde L, Pan P, Bressan R, Mojtabai R, Evans-Lacko S. The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil. Epidemiology And Psychiatric Sciences 2021, 30: e69. PMID: 36178130, PMCID: PMC8581950, DOI: 10.1017/s2045796021000561.Peer-Reviewed Original ResearchConceptsBullying perpetrationAdverse educational outcomesPsychiatric conditionsEducational outcomesWell-Being Behavior AssessmentImpact of fearHigh family riskMental health problemsFamily riskLiteracy performanceGrade repetitionChild psychiatric conditionsFuture educational outcomesCommunity cohortPopulation attributable risk percentageSchool dropoutPerpetrationNegative long-term effectsSample attritionAttributable risk percentageLarge Brazilian cohortBehavior assessmentNegative impactRobust negative impactBrazilian childrenMental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersA randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents
Fatori D, Fonseca Zuccolo P, Shephard E, Brentani H, Matijasevich A, Archanjo Ferraro A, Aparecida Fracolli L, Chiesa AM, Leckman J, Constantino Miguel E, V. Polanczyk G. A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. Scientific Reports 2021, 11: 14432. PMID: 34257407, PMCID: PMC8277870, DOI: 10.1038/s41598-021-93938-7.Peer-Reviewed Original ResearchConceptsWeeks of pregnancyAdolescent mothersNurse Home Visiting ProgramStandardized effect sizeChild's ageHome Visiting ProgramTrajectories of outcomesInfant Development-Third EditionEffect sizeLow-income adolescent mothersChildren's expressive language developmentAnthropometric indicesNurse homeDaily stimulationEndpoint assessmentBayley ScalesPregnant adolescentsVisiting ProgramExpressive language developmentPromising interventionChild developmentIntervention effectsPregnancyPoor urban areasAlpha frequencyPost-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil
Busatto G, de Araújo A, da Silva Duarte A, Levin A, Guedes B, Kallas E, Pinna F, de Souza H, da Silva K, Sawamura M, Seelaender M, Imamura M, Garcia M, Forlenza O, Nitrini R, Damiano R, Rocha V, Batisttella L, de Carvalho C, Initiative O, da Costa Leite C, Gomes C, Burdmann E, Miguel E, Cerri G, Fonseca G, Hallak J, Krieger J, Yu L, Castro L, Corrêa M, Mancini M, Rossi M, Gouveia N, Lotufo P, Bento R, Chammas R, Francisco R, Mauad T, Avelino-Silva T, Filho W, Group H, Bonfá E, Utiyama E, Segurado A, Perondi B, Miethke-Morais A, Montal A, Harima L, Fusco S, Silva M, Rocha M, Marcilio I, Rios I, Kawano F, de Jesus M, Carmo C, Tanaka C, Marchini J, Ferreira J, Oliveira M, Guimarães T, dos Santos Lázari C, Sabino E, MC Magri M, Barros-Filho T, Francisco M. Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil. BMJ Open 2021, 11: e051706. PMID: 34193506, PMCID: PMC8249176, DOI: 10.1136/bmjopen-2021-051706.Peer-Reviewed Original ResearchConceptsMultidisciplinary assessmentLaboratory-confirmed COVID-19SARS-CoV-2 infectionProspective observational evaluationCohort of patientsCOVID-19 inpatientsPost-acute sequelaeProspective observational studyLarge academic health centerGreater disease severityCOVID-19Cardiopulmonary functioningMultiorgan symptomsEligible subjectsInflammatory markersPeer-reviewed journalsResearch Ethics CommitteeBlood testsClinical manifestationsMuscle ultrasoundOlfactory statusHealth centersObservational studyDisease featuresPathophysiological investigationsPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variablesPromoting mother‐infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home‐visiting program for adolescent mothers in Brazil
Alarcão FSP, Shephard E, Fatori D, Amável R, Chiesa A, Fracolli L, Matijasevich A, Brentani H, Nelson CA, Leckman J, Miguel EC, Polanczyk GV. Promoting mother‐infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home‐visiting program for adolescent mothers in Brazil. Developmental Science 2021, 24: e13113. PMID: 33844435, PMCID: PMC8596406, DOI: 10.1111/desc.13113.Peer-Reviewed Original ResearchConceptsMother-infant attachmentHome visit programHealthy parent-child relationshipsEarly attachment relationshipsAdolescent mothersParent-child relationshipMother-infant interactionGood social behaviourMother-infant relationshipSocial processingAttachment relationshipsNeural correlatesNc amplitudeMother's faceElectrophysiological correlatesAge 6 monthsHome-visiting interventionInfant developmentSocial behaviorPregnant youthSecondary outcomesMiddle-income countriesFirst trimesterMother's healthIntervention group
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosisPredicting marriage and divorce in obsessive-compulsive disorder
Muhlbauer J, Ferrão Y, Eppingstall J, Albertella L, do Rosário M, Miguel E, Fontenelle L. Predicting marriage and divorce in obsessive-compulsive disorder. Journal Of Sex & Marital Therapy 2020, 47: 90-98. PMID: 32783604, DOI: 10.1080/0092623x.2020.1804021.Peer-Reviewed Original ResearchSocial losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsMaternal Parenting Electronic Diary in the Context of a Home Visit Intervention for Adolescent Mothers in an Urban Deprived Area of São Paulo, Brazil: Randomized Controlled Trial
Fatori D, Argeu A, Brentani H, Chiesa A, Fracolli L, Matijasevich A, Miguel E, Polanczyk G. Maternal Parenting Electronic Diary in the Context of a Home Visit Intervention for Adolescent Mothers in an Urban Deprived Area of São Paulo, Brazil: Randomized Controlled Trial. JMIR MHealth And UHealth 2020, 8: e13686. PMID: 32720906, PMCID: PMC7420524, DOI: 10.2196/13686.Peer-Reviewed Original ResearchConceptsWeeks of pregnancyMonths of ageCompliance rateAdolescent mothersNurse homePregnant adolescentsDeprived areasHome-visiting interventionElectronic daily diaryLow-income adolescent mothersMaternal parentingControlled TrialsMiddle-income countriesAdverse outcomesEligibility criteriaUrban deprived areasControl groupPregnancyMaternal parenting behaviorsDaily diariesElectronic diaryMonthsInterventionMothersWeeks