2019
Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Shannahoff-Khalsa D, Fernandes RY, de B. Pereira C, March JS, Leckman JF, Golshan S, Vieira MSR, Polanczyk GV, Miguel EC, Shavitt RG. Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial. Frontiers In Psychiatry 2019, 10: 793. PMID: 31780963, PMCID: PMC6859828, DOI: 10.3389/fpsyt.2019.00793.Peer-Reviewed Original ResearchY-BOCS scoresFirst-line therapyObsessive-compulsive disorderClinical trialsSecondary measuresY-BOCSShort Form-36 Health SurveyBaseline Y-BOCS scoresCompulsive ScaleGreater improvementRelative efficacyClinical Global ImpressionEffective treatment scheduleYale-Brown Obsessive Compulsive ScaleHigh psychosocial impairmentBeck Depression InventoryBeck Anxiety InventoryLife-long disorderObsessive Compulsive ScaleYale-Brown ObsessiveYoga meditationLine therapyPrimary outcomeTreat analysisReuptake inhibitors
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbidities
2014
Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder.
Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. Journal Of Neurosurgery 2014, 121: 123-30. PMID: 24702323, DOI: 10.3171/2014.2.jns131423.Peer-Reviewed Original ResearchConceptsLimbic system surgeryClinical outcomesWorse responseMean Y-BOCS scoreTreatment-refractory obsessive-compulsive disorderSymptom dimensionsPreoperative symptom severityWorse clinical outcomesTreatment-refractory patientsYale-Brown Obsessive Compulsive ScaleY-BOCS scoresSymptom Checklist scoresHoarding dimensionObsessive Compulsive ScaleSurgery needObsessive-compulsive disorderSurgical modalitiesAblative surgeryPoor responseWorse outcomesTreatment outcomesDimensional Yale-Brown Obsessive Compulsive ScaleYBOCS scoresPatientsSurgery
2012
‘Impulsive compulsivity’ in obsessive-compulsive disorder: A phenotypic marker of patients with poor clinical outcome
Kashyap H, Fontenelle L, Miguel E, Ferrão Y, Torres A, Shavitt R, Ferreira-Garcia R, do Rosário M, Yücel M. ‘Impulsive compulsivity’ in obsessive-compulsive disorder: A phenotypic marker of patients with poor clinical outcome. Journal Of Psychiatric Research 2012, 46: 1146-1152. PMID: 22647523, DOI: 10.1016/j.jpsychires.2012.04.022.Peer-Reviewed Original ResearchConceptsPoor clinical outcomeObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleSubstance use disorders
2011
Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment
Miguita K, Cordeiro Q, Shavitt R, Miguel E, Vallada H. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arquivos De Neuro-Psiquiatria 2011, 69: 283-287. PMID: 21625751, DOI: 10.1590/s0004-282x2011000300003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, TricyclicClomipramineDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenotypeHumansMaleMutationNorepinephrine Plasma Membrane Transport ProteinsObsessive-Compulsive DisorderPolymorphism, GeneticReceptors, SerotoninSerotonin Plasma Membrane Transport ProteinsYoung AdultSuicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research Consortium
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean score
2008
Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities
2005
Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder
Diniz J, Rosario-Campos M, Hounie A, Curi M, Shavitt R, Lopes A, Miguel E. Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. Journal Of Psychiatric Research 2005, 40: 487-493. PMID: 16289552, DOI: 10.1016/j.jpsychires.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChi-Square DistributionDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMultivariate AnalysisObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesPsychometricsRetrospective StudiesSeverity of Illness IndexTic DisordersTourette SyndromeConceptsObsessive-compulsive disorderTourette syndromeOCD patientsVocal ticsYale Global Tic Severity ScaleNumber of comorbiditiesStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleSymptom onsetChronic motorTic disordersCommon disorderSeverity ScalePatientsClinical InterviewChronic ticsDSM-IVBehaviors InterviewCompulsive ScaleSomatic obsessionsDisordersCompulsive disorderOCD phenotype
2001
Adults With Early-Onset Obsessive-Compulsive Disorder
Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. Adults With Early-Onset Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2001, 158: 1899-1903. PMID: 11691698, DOI: 10.1176/appi.ajp.158.11.1899.Peer-Reviewed Original ResearchConceptsSymptom onsetObsessive-compulsive disorderSelective serotonin reuptake inhibitorsOCD patientsSerotonin reuptake inhibitorsEarlier symptom onsetEarly-onset groupLater symptom onsetOnset obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleComorbid tic disordersAdult OCD patientsObsessive Compulsive ScaleReuptake inhibitorsAdult outpatientsTic disordersTreatment outcomesOCD symptom onsetBimodal ageEarly onsetHeterogeneous disorderCompulsive ScaleDisordersAgePatients