2022
Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation
Busatto G, de Araujo A, Castaldelli-Maia J, Damiano R, Imamura M, Guedes B, de Rezende Pinna F, Sawamura M, Mancini M, da Silva K, Garcia M, Sumita N, Brunoni A, da Silva Duarte A, Burdmann E, Kallas E, Cerri G, Nitrini R, Bento R, Rocha V, de Souza H, Miguel E, de Carvalho C, Forlenza O, Batistella L. Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation. Psychological Medicine 2022, 52: 2387-2398. PMID: 35521752, PMCID: PMC9151630, DOI: 10.1017/s0033291722001374.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPost-acute sequelaeC-reactive proteinSystemic inflammationBlood levelsPhysical disabilityD-dimer blood levelsCentral nervous system manifestationsPersistent physical disabilityPersistent systemic inflammationNervous system manifestationsSevere COVID-19Cognitive manifestationsPoor physical performanceElevated blood levelsCoronavirus disease 2019Pattern of symptomsDifferent organ systemsExploratory factor analysisSame followSystem manifestationsD-dimerClinical manifestationsKidney dysfunctionPerson visits
2016
Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
Mansur R, Cunha G, Asevedo E, Zugman A, Rizzo L, Grassi-Oliveira R, Levandowski M, Gadelha A, Pan P, Teixeira A, McIntyre R, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage. Psychoneuroendocrinology 2016, 71: 94-101. PMID: 27258821, DOI: 10.1016/j.psyneuen.2016.05.015.Peer-Reviewed Original ResearchConceptsParental mood disorderMental health problemsSerum interleukin-6Interleukin-6Perinatal complicationsEnvironmental risk factorsHealth problemsRisk factorsSerum levelsPsychiatric diagnosisParents' psychiatric diagnosisHigher serum levelsHigh Risk Cohort StudyMultiple risk factorsSocial disadvantageCohort studySystemic inflammationSocio-demographic characteristicsInflammatory activationMood disordersPsychiatric disordersDisorder pathogenesisComplicationsFamilial riskCumulative risk model