2017
Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle
Reimer A, de Oliveira A, Diniz J, Hoexter M, Miguel E, Milad M, Brandão M. Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle. Neuropharmacology 2017, 131: 104-115. PMID: 29225044, DOI: 10.1016/j.neuropharm.2017.12.015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderFear extinctionOCD patientsTreatment of OCDFear extinction retentionExtinction retention deficitsFear extinction trainingOCD pathophysiologyOCD-like symptomsAnterior cingulate cortexFear inhibitionExtinction retentionAccount sex differencesEstrous cycleExtinction trainingRetention deficitsRepetitive behaviorsDistinct neurotransmitter systemsMedial prefrontalUntreated OCD patientsCingulate cortexAnimal modelsSelf-grooming behaviorBrain areasEstrous cycle phase
2012
Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients
Ferrão Y, Shavitt R, Prado H, Fontenelle L, Malavazzi D, de Mathis M, Hounie A, Miguel E, do Rosário M. Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients. Psychiatry Research 2012, 197: 253-258. PMID: 22361443, DOI: 10.1016/j.psychres.2011.09.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSensory phenomenaOCD patientsConsecutive OCD patientsPresence/severityLogistic regression analysisFrequency/severityClinical characteristicsTic disordersFamily historyRepetitive behaviorsPatientsTourette syndromeGreater severityPsychopathological aspectsLevel of insightSeverityDisordersSymptom dimensionsRegression analysisFurther investigationSubstantial numberOC symptomsSymmetry/
1997
Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome
Miguel E, Baer L, Coffey B, Rauch S, Savage C, O'Sullivan R, Phillips K, Moretti C, Leckman J, Jenike M. Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome. The British Journal Of Psychiatry 1997, 170: 140-145. PMID: 9093502, DOI: 10.1192/bjp.170.2.140.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive behaviorsSensory phenomenaAutonomic anxietyMore cognitionsOCD groupGilles de la Tourette's syndromeOCD subtypesSubjective experienceGTS groupSemi-structured interviewsCognitionTourette syndromeValid predictorPhenomenological differencesAnxietyLa Tourette's syndromeAdult outpatientsPhenomenological studyDisordersBehaviorTreatment responsePredictorsInterviewsExperience
1995
Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's disorder.
Miguel E, Coffey B, Baer L, Savage C, Rauch S, Jenike M. Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's disorder. The Journal Of Clinical Psychiatry 1995, 56: 246-55. PMID: 7775367.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive behaviorsOCD patientsCognitive phenomenaSensory phenomenaAutonomic anxietyComorbid obsessive-compulsive disorderTourette's disorderAffective experienceSuch sensationsTourette's subjectsAnxietyCognitionOCD outpatientsStructured interviewsTourette patientsDisordersSuch symptomsTouretteBehaviorRecent evidenceOutpatientsSubjectsInterviewsPhenomenology