2023
The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study
Grevet L, Teixeira D, Pan P, Jackowski A, Zugman A, Miguel E, Rohde L, Salum G. The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study. European Child & Adolescent Psychiatry 2023, 33: 1863-1873. PMID: 37650992, DOI: 10.1007/s00787-023-02283-9.Peer-Reviewed Original ResearchOverall cortical thicknessDuration of breastfeedingTotal intracranial volumeCortical thicknessBrain developmentIntracranial volumeLong-term health benefitsHealth benefitsHigh-risk cohortTotal brain volumeGlobal cortical thicknessStructural brain developmentMental health benefitsMultiple confoundersCortical areasMRI scansBrain areasBrain volumeBreastfeedingMRI T1Time pointsBrain measuresEarly adulthoodYoung adulthoodLongitudinal study
2021
Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factors
2019
Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus
Biazoli C, Salum G, Gadelha A, Rebello K, Moura L, Pan P, Brietzke E, Miguel E, Rohde L, Bressan R, Jackowski A, Sato J. Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. Brain Imaging And Behavior 2019, 14: 961-970. PMID: 30868400, DOI: 10.1007/s11682-019-00073-z.Peer-Reviewed Original ResearchConceptsRight superior temporal gyrusSuperior temporal gyrusTemporal gyrusExtended language networkDifferent developmental trajectoriesBrain functional organizationSchool-based sampleFunctional organizationStructural neuroimaging findingsCognitive controlSocioeconomic statusLanguage networkExternalizing problemsInternalizing problemsDevelopmental trajectoriesEmotional problemsSpontaneous activityRegional spontaneous activityLanguage processingFMRI featuresBrain regionsBrain areasNeuroimaging findingsFunctional networksLinguistic environmentSU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS
Lisboa B, Tahira A, Sant'Anna A, Oliveira K, Miguel E, Hoexter M, Farfel J, Brentani H. SU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS. European Neuropsychopharmacology 2019, 29: s927. DOI: 10.1016/j.euroneuro.2017.08.261.Peer-Reviewed Original ResearchObsessive-compulsive disorderNucleus accumbensSubgenual cingulate gyrusCortico-striatal circuitryOrbitofrontal cortexAffective circuitryCingulate gyrusCaudate nucleusBrain areasCognitive circuitryBrazilian Aging Brain Study GroupCompulsive disorderEnsheathment of neuronsEnrichment analysisBackground Obsessive-compulsive disorderDrug metabolic processFunctional neuroimaging studiesCortico-striatal loopsDopaminergic synapsesBrain BankThalamic circuitryGene expressionStudy groupNeurological system processPsychiatric disorders
2018
Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Bressan R, Jackowski A. Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems. European Child & Adolescent Psychiatry 2018, 28: 835-845. PMID: 30392120, DOI: 10.1007/s00787-018-1240-y.Peer-Reviewed Original ResearchConceptsFamily environmentMental health outcomesFamily coherenceEmotional problemsOrbitofrontal cortexTemporal poleResting-state fMRI dataLeft temporal poleSpontaneous brain oscillationsChild's family environmentRight orbitofrontal cortexOscillatory neural activityHealth outcomesBrain oscillationsBehavioral problemsNeural activityFMRI dataFMRI metricsBrain areasLow-frequency fluctuationsFractional amplitudeLower incidenceSpontaneous activityHigh incidenceExploratory study
2017
Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle
Reimer A, de Oliveira A, Diniz J, Hoexter M, Miguel E, Milad M, Brandão M. Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle. Neuropharmacology 2017, 131: 104-115. PMID: 29225044, DOI: 10.1016/j.neuropharm.2017.12.015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderFear extinctionOCD patientsTreatment of OCDFear extinction retentionExtinction retention deficitsFear extinction trainingOCD pathophysiologyOCD-like symptomsAnterior cingulate cortexFear inhibitionExtinction retentionAccount sex differencesEstrous cycleExtinction trainingRetention deficitsRepetitive behaviorsDistinct neurotransmitter systemsMedial prefrontalUntreated OCD patientsCingulate cortexAnimal modelsSelf-grooming behaviorBrain areasEstrous cycle phase