2016
Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopment
2015
ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER
Hoexter M, Diniz J, Lopes A, Batistuzzo M, Shavitt R, Dougherty D, Duran F, Bressan R, Busatto G, Miguel E, Sato J. ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2015, 32: 900-908. PMID: 26032588, DOI: 10.1002/da.22380.Peer-Reviewed Original ResearchConceptsTreatment-naïve OCD patientsObsessive-compulsive disorderTreatment responseIndependent cohortOCD patientsOFC thicknessRefractory OCD patientsTreatment-naïve patientsOrbitofrontal cortex thicknessSecond independent cohortLogistic regression modelsBaseline thicknessClinical trialsTreatment outcomesInitial cohortClinical utilityOrbitofrontal thicknessIneffective treatmentPatientsCohortMedial OFCNeuroimaging techniquesMorphometric biomarkersBiomarkersCortex thickness