2001
OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticks
1992
Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens
de Souza M, Fikrig E, Smith A, Flavell R, Barthold SW. Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens. The Journal Of Infectious Diseases 1992, 165: 471-478. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, ImmunologicFlow CytometryImmunoglobulin GImmunoglobulin MLipopolysaccharidesLipoproteinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HRecombinant ProteinsSpecific Pathogen-Free OrganismsConceptsBorrelia burgdorferi antigensNaive splenocytesNonspecific proliferationProliferative responseB. burgdorferiC3H/HeNCrlBR miceRecombinant outer surface proteinB cell-enriched fractionC3H/HeJ miceNonspecific proliferative responseAntigen-specific proliferationStrains of miceCell-enriched fractionB. burgdorferi spirochetesIgG synthesisHeJ miceB cellsMitogenic effectOuter surface proteinsMurine lymphocytesLyme borreliosisMiceSplenocytesBurgdorferiAntigen