2017
Zika virus causes testicular atrophy
Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.Peer-Reviewed Original ResearchConceptsZika virusTesticular atrophyAcute viremic phaseZIKV-infected miceMosquito-borne flavivirusTestosterone-producing Leydig cellsProgressive testicular atrophyZIKV persistenceFetal infectionViremic phaseNeonatal abnormalitiesSerum testosteroneZIKV infectionNeurological dysfunctionSubcutaneous injectionZIKV replicationLeydig cellsVirus replicationVertical transmissionEpithelial cellsMiceViral RNAReproductive deficienciesAtrophyMale fertility
2016
Zika virus infection of Hofbauer cells
Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal Of Reproductive Immunology 2016, 77 PMID: 27966815, PMCID: PMC5299062, DOI: 10.1111/aji.12613.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeHofbauer cellsZika virusZIKV infectionDevelopment of CZSDengue virusSpread of ZIKVVertical transmissionFetal placental macrophagesPlacental Hofbauer cellsZika virus infectionAntenatal infectionNeonatal outcomesPlacental responsesZika syndromeVirus infectionCurrent evidenceCongenital abnormalitiesRecent studiesNeonatal developmentFetal capillariesRelated flavivirusesInfectionSpecific molecular mechanismsCertain viruses
2012
Horizontal and Vertical Transmission of West Nile Virus Genotype NY99 by Culex salinarius and Genotypes NY99 and WN02 by Culex tarsalis
Anderson JF, Main AJ, Cheng G, Ferrandino FJ, Fikrig E. Horizontal and Vertical Transmission of West Nile Virus Genotype NY99 by Culex salinarius and Genotypes NY99 and WN02 by Culex tarsalis. American Journal Of Tropical Medicine And Hygiene 2012, 86: 134-139. PMID: 22232464, PMCID: PMC3247122, DOI: 10.4269/ajtmh.2012.11-0473.Peer-Reviewed Original Research
2008
Extrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae)
Anderson J, Main A, Delroux K, Fikrig E. Extrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 51 DOI: 10.1603/0022-2585(2008)45[445:eipfha]2.0.co;2.Peer-Reviewed Original ResearchWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 13Day 16Extrinsic incubationMembrane feederHorizontal transmission ratesCulex pipiens pipiens L.Initiation of amplificationFirst bloodmealVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNVExtrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae).
Anderson J, Main A, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-51. PMID: 18533438, DOI: 10.1603/0022-2585(2008)45[445:eipfha]2.0.co;2.Peer-Reviewed Original ResearchConceptsWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 13Day 16Extrinsic incubationMembrane feederCulex pipiens pipiens L.Horizontal transmission ratesInitiation of amplificationFirst bloodmealVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNVExtrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae)
Anderson J, Main A, Delroux K, Fikrig E. Extrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-451. DOI: 10.1603/0022-2585%282008%2945%5b445%3aeipfha%5d2.0.co%3b2.Peer-Reviewed Original ResearchWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 16Extrinsic incubationMembrane feederCulex pipiens pipiens L.Horizontal transmission ratesFirst bloodmealInitiation of amplificationVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNVBloodmealExtrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae)
Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-451. DOI: 10.1093/jmedent/45.3.445.Peer-Reviewed Original ResearchConceptsWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 13Day 16Extrinsic incubationMembrane feederHorizontal transmission ratesCulex pipiens pipiens L.Initiation of amplificationFirst bloodmealVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNV