2004
Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity
Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity. American Journal Of Pathology 2004, 165: 977-985. PMID: 15331421, PMCID: PMC1618599, DOI: 10.1016/s0002-9440(10)63359-7.Peer-Reviewed Original ResearchConceptsChronic infectionHumoral immunityProtective nicheB. burgdorferiDecorin expressionLower decorin expressionDecorin-deficient miceWild-type miceStrong immune responseDecorin-binding protein ASpirochete burdenUrinary bladderImmune responsePersistent infectionMurine infectionEarly infectionInfectionExtracellular microbesDbpA expressionLyme disease spirocheteBorrelia burgdorferiC expressionTargeted disruptionBurgdorferiMice
1999
Borrelia burgdorferi erpT expression in the arthropod vector and murine host
Fikrig E, Chen M, Barthold S, Anguita J, Feng W, Telford S, Flavell R. Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Molecular Microbiology 1999, 31: 281-290. PMID: 9987129, DOI: 10.1046/j.1365-2958.1999.01171.x.Peer-Reviewed Original ResearchConceptsRNA polymerase chain reactionPolymerase chain reactionB. burgdorferi-infected miceBurgdorferi-infected miceB. burgdorferiMurine infectionChain reactionMurine hostImmunization of miceExtracutaneous sitesDifferential antibodyPersistent infectionArthropod vectorsIndirect immunofluorescenceBSK II mediumMiceImmunofluorescence studiesInfectionBurgdorferiAntibodiesAntigenBorrelia burgdorferi genesSmall minorityMammalian hostsNorthern blot
1997
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.
Fikrig E, Barthold SW, Chen M, Chang CH, Flavell RA. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. The Journal Of Immunology 1997, 159: 5682-6. PMID: 9548512, DOI: 10.4049/jimmunol.159.11.5682.Peer-Reviewed Original ResearchConceptsMHC class IIT cellsClass IINaive C3H/HeN miceC3H/HeN miceC57/BL6 miceCIITA-deficient miceRegression of arthritisResolution of arthritisResolution of carditisDevelopment of arthritisMurine Lyme borreliosisMHC class II transactivatorClass II moleculesClass II transactivatorIgG2b AbsProtective antibodiesBL6 miceHeN miceDeficient miceProtective AbsSCID micePersistent infectionArthritisCD4 repertoire