2016
Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review
Han P, Weng C, Khawaja H, Nagarajan N, Schneider E, Umbricht C, Witwer K, Zeiger M. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review. Thyroid 2015, 25: 1322-1329. PMID: 26414548, DOI: 10.1089/thy.2015.0193.Peer-Reviewed Original ResearchConceptsAggressive clinicopathologic featuresPapillary thyroid cancerClinicopathologic featuresThyroid cancerRoutine central lymph node dissectionSystematic reviewCentral lymph node dissectionMiR expression levelsLymph node dissectionLymph node metastasisLarger tumor sizeUseful prognostic markerExpression levelsWeb of ScienceFull-text publicationsNode dissectionLymphovascular invasionDistant metastasisIndependent predictorsNode metastasisAggressive featuresPrognostic significanceProspective studyTumor sizePrognostic marker
2012
BRAF V600E mutation and Its Association with Clinicopathological Features of Papillary Thyroid Cancer: A Meta-Analysis
Li C, Lee K, Schneider E, Zeiger M. BRAF V600E mutation and Its Association with Clinicopathological Features of Papillary Thyroid Cancer: A Meta-Analysis. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4559-4570. PMID: 23055546, PMCID: PMC3513529, DOI: 10.1210/jc.2012-2104.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAmino Acid SubstitutionCarcinomaCarcinoma, PapillaryFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGlutamic AcidHumansLymphatic MetastasisMaleMutation, MissenseProto-Oncogene Proteins B-rafSex CharacteristicsThyroid Cancer, PapillaryThyroid NeoplasmsTumor BurdenValineConceptsLymph node metastasisPapillary thyroid cancerLymph node dissectionTall cell variant papillary thyroid cancerRoutine central lymph node dissectionCentral lymph node dissectionClassic papillary thyroid cancerNode dissectionBRAF V600E mutationClinicopathological featuresAbsence of capsuleTumor sizeMale genderOdds ratioThyroid cancerBRAF mutationsMantel-Haenszel pooled odds ratiosPresence of LNMV600E mutationStudy-specific odds ratiosManagement of patientsPooled odds ratioAggressive clinicopathological featuresImportant clinical decisionsConsecutive patients
2011
Predictive factors of malignancy in pediatric thyroid nodules
Roy R, Kouniavsky G, Schneider E, Allendorf JD, Chabot JA, Logerfo P, Dackiw AP, Colombani P, Zeiger MA, Lee JA. Predictive factors of malignancy in pediatric thyroid nodules. Surgery 2011, 150: 1228-1233. PMID: 22136845, DOI: 10.1016/j.surg.2011.09.023.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsy specimensPediatric thyroid nodulesPositive predictive valuePalpable lymphadenopathyThyroid nodulesThyroid cancerFamily historyPredictive valueAspiration biopsy specimensPediatric thyroidectomyFinal pathologyClinical factorsClinicopathologic factorsRetrospective reviewTertiary hospitalPredictive factorsHypoechoic lesionsBiopsy specimensHypoechoic nodulesIndeterminate lesionsMalignancyFNAB resultsLymphadenopathyGreater riskCancer