2021
Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer
Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer. Pancreas 2021, 50: 1267-1273. PMID: 34860810, DOI: 10.1097/mpa.0000000000001919.Peer-Reviewed Original Research
2018
Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA total
2017
Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset?
Sahli Z, Umbricht C, Schneider E, Zeiger M. Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset? Thyroid 2017, 27: 1393-1399. PMID: 28859553, DOI: 10.1089/thy.2017.0238.Peer-Reviewed Original ResearchConceptsCancer prevalenceSuspicious fine-needle aspiration (FNA) cytologyNon-invasive follicular thyroid neoplasmFine needle aspiration cytologyThyroid cancer prevalencePapillary-like nuclear featuresFollicular thyroid neoplasmPrecancerous lesionsDifferential diagnosisAspiration cytologyLatter diagnosisClinical validityThyroid neoplasmsOriginal validation studyMolecular panelDiagnostic markerMolecular testsNuclear featuresNIFTP reclassificationPrevalence
2016
Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review
Han P, Weng C, Khawaja H, Nagarajan N, Schneider E, Umbricht C, Witwer K, Zeiger M. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review. Thyroid 2015, 25: 1322-1329. PMID: 26414548, DOI: 10.1089/thy.2015.0193.Peer-Reviewed Original ResearchConceptsAggressive clinicopathologic featuresPapillary thyroid cancerClinicopathologic featuresThyroid cancerRoutine central lymph node dissectionSystematic reviewCentral lymph node dissectionMiR expression levelsLymph node dissectionLymph node metastasisLarger tumor sizeUseful prognostic markerExpression levelsWeb of ScienceFull-text publicationsNode dissectionLymphovascular invasionDistant metastasisIndependent predictorsNode metastasisAggressive featuresPrognostic significanceProspective studyTumor sizePrognostic marker