2016
Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review
Han P, Weng C, Khawaja H, Nagarajan N, Schneider E, Umbricht C, Witwer K, Zeiger M. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review. Thyroid 2015, 25: 1322-1329. PMID: 26414548, DOI: 10.1089/thy.2015.0193.Peer-Reviewed Original ResearchConceptsAggressive clinicopathologic featuresPapillary thyroid cancerClinicopathologic featuresThyroid cancerRoutine central lymph node dissectionSystematic reviewCentral lymph node dissectionMiR expression levelsLymph node dissectionLymph node metastasisLarger tumor sizeUseful prognostic markerExpression levelsWeb of ScienceFull-text publicationsNode dissectionLymphovascular invasionDistant metastasisIndependent predictorsNode metastasisAggressive featuresPrognostic significanceProspective studyTumor sizePrognostic marker
2012
Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer?
Lee K, Li C, Schneider E, Wang Y, Somervell H, Krafft M, Umbricht C, Zeiger M. Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer? Surgery 2012, 152: 977-983. PMID: 23062653, PMCID: PMC3715093, DOI: 10.1016/j.surg.2012.08.019.Peer-Reviewed Original ResearchConceptsCentral lymph node dissectionLymph node metastasisPapillary thyroid cancerBRAF mutation statusMutation statusBRAF mutationsNode metastasisSurgical managementClinicopathologic featuresThyroid cancerPresence of LNMRoutine central lymph node dissectionMultivariate logistic regression analysisLymph node dissectionAggressive clinicopathologic featuresInstitutional review board approvalLogistic regression analysisFine-needle aspirationFine-needle aspiration samplesReview board approvalNode dissectionTotal thyroidectomyLymphatic invasionChi-square analysisBoard approvalBRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer
Zeiger M, Schneider E. BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer. Annals Of Surgical Oncology 2012, 20: 3-4. PMID: 22941167, DOI: 10.1245/s10434-012-2614-x.Peer-Reviewed Original Research