2010
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes E, Randall P, Santerre J, Given A, Sager T, Correa M, Salamone J. Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience 2010, 170: 268-280. PMID: 20600675, PMCID: PMC3268040, DOI: 10.1016/j.neuroscience.2010.05.068.Peer-Reviewed Original ResearchConceptsEffects of dopamineEffects of ecopipamSame striatal neuronsEffects of adenosineAbility of adenosineEffort-related impairmentsEffort-related choiceFood-seeking behaviorEffort-related choice behaviorConcurrent leverChow intakeDA transmissionSelective adenosine antagonistsStriatal neuronsReceptor antagonistRodent chowDopamine D1D2 antagonismPsychiatric symptomsPsychomotor slowingAdenosine antagonistEffort-related processesBrain circuitryAntagonistMesolimbic dopamineRole of dopamineadenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Salamone J, Correa M, Farrar A, Nunes E, Collins L. Role of dopamineadenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation. Future Neurology 2010, 5: 377-392. DOI: 10.2217/fnl.10.19.Peer-Reviewed Original ResearchEffort-related processesDopamine depletionEffort-related decision makingEffort-related decisionTendency of ratsEffort-related choiceEnergy-related disordersActivational aspectsIntra-accumbens injectionsFood motivationBrain circuitryAccumbens dopamine depletionsBrain dopamineNeuromodulator adenosineMotivationNucleus accumbensPathological aspectsDecision makingDopamine DRecent evidenceAntagonistAdenosineAnergiaAspectsAccumbens
2009
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure
Mott A, Nunes E, Collins L, Port R, Sink K, Hockemeyer J, Müller C, Salamone J. The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology 2009, 204: 103. PMID: 19132351, PMCID: PMC2875244, DOI: 10.1007/s00213-008-1441-z.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A1 Receptor AntagonistsAdenosine A2 Receptor AntagonistsAnimalsBehavior, AnimalChoice BehaviorConditioning, OperantDopamine AntagonistsDose-Response Relationship, DrugDrug InteractionsHaloperidolMaleMaze LearningMotivationNucleus AccumbensPhysical ExertionPsychomotor PerformanceRatsRats, Sprague-DawleyReceptor, Adenosine A1Receptors, Adenosine A2Reinforcement ScheduleXanthinesConceptsEffort-related choiceMSX-3Antagonist haloperidolAdenosine A2A antagonist MSX-3Receptor antagonist MSX-3Adenosine A2A antagonismDA antagonist haloperidolDopamine antagonist haloperidolEffects of haloperidolEffort-related decision makingFood-seeking behaviorA2A antagonismDA transmissionUntreated ratsA1 antagonistD2 receptorsPsychiatric symptomsAdenosine A2APsychomotor slowingA1 antagonismEffort-related processesBrain circuitryFood-reinforced tasksHaloperidolBehavioral activation