2011
Control of TH17 cells occurs in the small intestine
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature 2011, 475: 514-518. PMID: 21765430, PMCID: PMC3148838, DOI: 10.1038/nature10228.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesCD3 ComplexCD4-Positive T-LymphocytesCell MovementChemokine CCL20Disease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleGene Expression ProfilingGene Expression RegulationInfluenza A virusInterleukin-17Intestine, SmallMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicOrthomyxoviridae InfectionsReceptors, CCR6SepsisStaphylococcal InfectionsTh17 CellsConceptsTh17 cellsImmune systemSmall intestineCD3-specific antibodiesT helper cellsModel of sepsisNumerous autoimmune diseasesRheumatoid arthritisMultiple sclerosisAutoimmune diseasesHelper cellsGastrointestinal tractViral infectionIntestineCellsSepsisTh17ArthritisSclerosisPathogenesisInfectionInfluenzaDiseaseMiceTract
2004
Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2
Lainez B, Fernandez-Real J, Romero X, Esplugues E, Cañete J, Ricart W, Engel P. Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2. International Immunology 2004, 16: 169-177. PMID: 14688072, DOI: 10.1093/intimm/dxh014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlternative SplicingAnimalsArthritis, RheumatoidBase SequenceChlorocebus aethiopsCloning, MolecularCOS CellsEnzyme-Linked Immunosorbent AssayEtanerceptFemaleHumansImmunoglobulin GMaleMiddle AgedMolecular Sequence DataProtein IsoformsReceptors, Tumor Necrosis FactorSepsisTransfectionTumor Necrosis Factor-alphaConceptsAlternative splicingCell death inductionTNF-alpha-induced apoptosisExtracellular ectodomainMultiple inflammatory pathologiesCytoplasmic domainNovel isoformHuman TNFR2COS cellsExpression studiesDeath inductionCell typesTNF-alpha functionReceptors TNFR1SplicingExon 7Soluble formIsoformsBiological effectsBiological activityTumor necrosis factor receptor 2Pleiotropic cytokineNecrosis factor receptor 2Factor receptor 2TNFR2