2016
TFH cells progressively differentiate to regulate the germinal center response
Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology 2016, 17: 1197-1205. PMID: 27573866, PMCID: PMC5030190, DOI: 10.1038/ni.3554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody AffinityB-LymphocytesCD4 AntigensCell CommunicationCell DifferentiationCells, CulturedGene Expression RegulationGerminal CenterHumansInterleukin-4InterleukinsMiceMice, Inbred C57BLMice, Mutant StrainsMutationNippostrongylusPositive Regulatory Domain I-Binding Factor 1Strongylida InfectionsT-Lymphocytes, Helper-InducerTranscription Factors
2015
Progressive differentiation of follicular B helper T cells regulates the germinal center response (IRC11P.430)
Herman E, Weinstein J, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. Progressive differentiation of follicular B helper T cells regulates the germinal center response (IRC11P.430). The Journal Of Immunology 2015, 194: 197.12-197.12. DOI: 10.4049/jimmunol.194.supp.197.12.Peer-Reviewed Original ResearchFollicular B helper T cellsHelper T cellsTfh cellsGerminal centersT cellsIL-21IL-4Thymus-dependent humoral immune responsesIL-21 mRNAB cell folliclesTfh cell differentiationCD4 T cellsHumoral immune responseSecondary lymphoid organsEffective antibody responseGerminal center responseAntibody-secreting cellsActivated B cellsTranscription factor Bcl6B cell maturationAntibody responseLymphoid organsImmune responseB cellsCenter response
2012
Bcl6 expression specifies the T follicular helper cell program in vivo
Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. Journal Of Experimental Medicine 2012, 209: 1841-1852. PMID: 22987803, PMCID: PMC3457730, DOI: 10.1084/jem.20120219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationCell DifferentiationCluster AnalysisDNA-Binding ProteinsGene ExpressionGene Expression ProfilingGene OrderGene TargetingGenes, ReporterGerminal CenterImmunologic MemoryMiceMice, TransgenicProto-Oncogene Proteins c-bcl-6Receptors, CXCR5T-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTranscription, GeneticConceptsEffector T cell lineagesFollicular helper cellsT cell differentiationT-cell lineageGerminal center reactionTfh cellsHelper cellsImmune responseReporter miceCenter reactionBCL6 expressionFide markerBona fide markersEarly phaseVivoBCL6Pivotal roleCell lineagesCell differentiationCellsCell programCXCR5TfhTranscription factorsReporter system