2015
Gatekeeper role of brain antigen‐presenting CD11c+ cells in neuroinflammation
Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. Gatekeeper role of brain antigen‐presenting CD11c+ cells in neuroinflammation. The EMBO Journal 2015, 35: 89-101. PMID: 26612827, PMCID: PMC4718005, DOI: 10.15252/embj.201591488.Peer-Reviewed Original ResearchConceptsPathogenic T cellsT cellsFrequent chronic inflammatory diseaseChronic inflammatory diseaseAntigen-presenting cellsInflammatory chemokines CCL5Autoimmune neuroinflammationPerivascular clustersTh17 cellsDendritic cellsMultiple sclerosisInflammatory diseasesChemokine CCL5Disease severityCNSGM-CSFExpression correlatesTwo-photon microscopyNeuroinflammationGatekeeper functionSurvivalCellsGatekeeper rolePotent typeImpaired enrichment
2011
Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner
Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner. Immunity 2011, 34: 554-565. PMID: 21511184, PMCID: PMC3113617, DOI: 10.1016/j.immuni.2011.01.020.Peer-Reviewed Original ResearchConceptsIL-10 signalingT cellsIL-10-dependent mannerIL-10-producing cellsIL-17A-producing CD4T cell-specific blockadeT helper 17 (Th17) cellsHelper 17 cellsIL-10 treatmentChronic inflammatory diseaseInterleukin-10 receptorRegulatory CD4Intestinal inflammationRegulatory cellsInflammatory diseasesExtracellular microorganismsReceptor αCell frequencySmall intestineHost defenseCD4Selective increaseDirect signalingVivoCells
2006
CD69 targeting differentially affects the course of collagen-induced arthritis
Sancho D, Gómez M, del Hoyo G, Lamana A, Esplugues E, Lauzurica P, Martinez-A C, Sánchez-Madrid F. CD69 targeting differentially affects the course of collagen-induced arthritis. Journal Of Leukocyte Biology 2006, 80: 1233-1241. PMID: 16921025, DOI: 10.1189/jlb.1205749.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, T-LymphocyteArthritis, ExperimentalCell ProliferationCollagen Type IIImmunoglobulin GInflammationInterferon-gammaLectins, C-TypeLymphocyte DepletionMiceMice, Inbred BALB CMice, Inbred DBAMice, KnockoutT-LymphocytesConceptsCollagen-induced arthritisCII-specific T cellsLymphocyte proliferative responsesChronic inflammatory diseaseActivation of leukocytesWild-type animalsInflammation correlatesAdoptive transferDBA/1 miceProinflammatory cytokinesInflammatory diseasesInflammatory fociCD69 expressionCD69 mAbT cellsImmune responseIFN-gammaInflammatory sitesProliferative responseCD69Type II collagenArthritisDecreased productionDiseaseMice