2002
Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation
Foxman EF, Zhang M, Hurst SD, Muchamuel T, Shen D, Wawrousek EF, Chan CC, Gery I. Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation. The Journal Of Immunology 2002, 168: 2483-2492. PMID: 11859142, DOI: 10.4049/jimmunol.168.5.2483.Peer-Reviewed Original ResearchConceptsExperimental autoimmune uveoretinitisOcular inflammationAutoimmune uveoretinitisInflammatory mediatorsInflamed eyesChemokine receptorsMouse eyeAg-specific Th1Chemokine mRNA productionInflammation-related moleculesRetinal pigment epithelium cellsPotential therapeutic targetRetinal pigment epitheliumPigment epithelium cellsReal-time RT-PCRMultiplicity of mediatorsTime RT-PCRAdoptive transferInfiltrating leukocytesUpstream cytokinesTh cellsVision lossLaser capture microdissectionTh2 cellsChemokine transcripts
1997
Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration
Campbell J, Foxman E, Butcher E. Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration. European Journal Of Immunology 1997, 27: 2571-2578. PMID: 9368612, DOI: 10.1002/eji.1830271016.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDCell AdhesionChemotaxis, LeukocyteDrug InteractionsHumansInterleukin-8NeutrophilsN-Formylmethionine Leucyl-PhenylalanineReceptors, Formyl PeptideReceptors, ImmunologicReceptors, InterleukinReceptors, Interleukin-8AReceptors, PeptideSignal TransductionTransfectionVascular Cell Adhesion Molecule-1ConceptsIL-8Leukocyte adhesionIL-8 receptor AChemoattractant receptorsComplex cytokine milieuInterleukin-8 receptorFormyl peptide receptorMultiple chemoattractant receptorsChemotactic responseFMLP-stimulated adhesionReceptor cross talkCytokine milieuChemokine receptorsLymphoid cellsLeukocyte migrationReceptor AFormyl peptidePeptide receptorHuman neutrophilsMultiple receptorsReceptorsMigratory responseChemoattractant responsesInvasive bacteriaAsymmetric inhibition