2019
Longitudinal molecular trajectories of diffuse glioma in adults
Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW. Longitudinal molecular trajectories of diffuse glioma in adults. Nature 2019, 576: 112-120. PMID: 31748746, PMCID: PMC6897368, DOI: 10.1038/s41586-019-1775-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultChromosomes, Human, Pair 1Chromosomes, Human, Pair 19Disease ProgressionGliomaHumansIsocitrate DehydrogenaseMutationPolymorphism, Single NucleotideRecurrenceConceptsAdult patientsDiffuse gliomasRecurrent gliomaOverall survivalPoor outcomeCurrent therapiesChromosome arms 1p/19qAcquired alterationsMajor subtypesTherapeutic resistanceGliomasGlioma developmentGene alterationsIDH mutationsGlioma subtypesPatientsHypermutator phenotypeDriver genesSubtypesClinical annotationSurvivalSubclonal selectionCell cycleAlterationsLittle evidenceGlioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics
Ostrom QT, Egan KM, Nabors LB, Gerke T, Thompson RC, Olson JJ, LaRocca R, Chowdhary S, Eckel‐Passow J, Armstrong G, Wiencke JK, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Houlston RS, Jenkins RB, Wrensch MR, Melin B, Amos CI, Huse JT, Barnholtz‐Sloan J, Bondy ML. Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics. International Journal Of Cancer 2019, 146: 739-748. PMID: 30963577, PMCID: PMC6785354, DOI: 10.1002/ijc.32318.Peer-Reviewed Original ResearchTranscriptome-wide association study identifies new candidate susceptibility genes for glioma
Atkins I, Kinnersley B, Ostrom QT, Labreche K, Il'yasova D, Armstrong GN, Eckel-Passow JE, Schoemaker MJ, Nöthen MM, Barnholtz-Sloan JS, Swerdlow AJ, Simon M, Rajaraman P, Chanock SJ, Shildkraut J, Bernstein JL, Hoffmann P, Jöckel KH, Lai RK, Claus EB, Olson SH, Johansen C, Wrensch MR, Melin B, Jenkins RB, Sanson M, Bondy ML, Houlston RS. Transcriptome-wide association study identifies new candidate susceptibility genes for glioma. Cancer Research 2019, 79: canres.2888.2018. PMID: 30709929, PMCID: PMC6522343, DOI: 10.1158/0008-5472.can-18-2888.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptome-wide association studyNovel risk lociRisk lociAssociation studiesCausal genesGenotype-Tissue Expression project dataNew candidate susceptibility genesGlioma risk variantsGWAS-identified variantsGWAS summary statisticsGlioma risk lociBonferroni-corrected significance levelCandidate susceptibility genesGWAS lociNew genesNovel lociGene expressionGenesLociSusceptibility variantsSusceptibility genesRisk variantsGlioma tumorigenesisNon-GBM tumorsLonger genotypically-estimated leukocyte telomere length is associated with increased meningioma risk
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. Journal Of Neuro-Oncology 2019, 142: 479-487. PMID: 30796745, PMCID: PMC6482066, DOI: 10.1007/s11060-019-03119-w.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesFemaleFollow-Up StudiesGenotypeHumansLeukocytesMaleMeningeal NeoplasmsMeningiomaPolymorphism, Single NucleotidePrognosisRisk FactorsTelomere HomeostasisConceptsMeningioma riskBrain tumorsNon-malignant brain tumoursMalignant brain tumorsEtiology of meningiomaHealthy controlsOdds ratioMeningioma patientsMeningioma casesSurvival rateLogistic regressionMeningiomasGermline DNATelomere lengthTumorsMultiple testingRiskEuropean ancestryWestern European ancestryPatientsPathophysiologyLymphocytesConclusionIncreasedEtiologyControl
2018
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston RS, Wiemels JL. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology 2018, 20: 1485-1493. PMID: 29762745, PMCID: PMC6176799, DOI: 10.1093/neuonc/noy077.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCase-Control StudiesChromosomes, Human, Pair 11FemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMeningeal NeoplasmsMeningiomaMiddle AgedPolymorphism, Single NucleotidePrognosisRisk FactorsYoung AdultConceptsGenome-wide association studiesRisk lociGenome-wide association analysisSusceptibility lociNeural crest-derived structuresSignificant heritable basisNumber of genesIndependent sample seriesNew susceptibility lociHeritable basisGenetic basisGenome ProjectAssociation studiesAssociation analysisLinkage disequilibriumLociMeningioma developmentReference panelPolygenic modelCentral roleUK10K dataAdult brain tumorsRIC8AMeningeal coveringsGenes
2012
Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma
Liu Y, Melin BS, Rajaraman P, Wang Z, Linet M, Shete S, Amos CI, Lau CC, Scheurer ME, Tsavachidis S, Armstrong GN, Houlston RS, Hosking FJ, Claus EB, Barnholtz-Sloan J, Lai R, Il’yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, LaChance D, Vick NA, Wrensch M, Davis F, McCarthy BJ, Andersson U, Thompson PA, Chanock S, The Gliogene Consortium, Bondy ML. Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma. Human Genetics 2012, 131: 1507-1517. PMID: 22688887, PMCID: PMC3604903, DOI: 10.1007/s00439-012-1187-x.Peer-Reviewed Original Research
2011
Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium
Shete S, Lau CC, Houlston RS, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, Yang P, Vick NA, Wrensch M, Davis FG, McCarthy BJ, Leung EH, Davis C, Cheng R, Hosking FJ, Armstrong GN, Liu Y, Yu RK, Henriksson R, Consortium T, Melin BS, Bondy ML. Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium. Cancer Research 2011, 71: 7568-7575. PMID: 22037877, PMCID: PMC3242820, DOI: 10.1158/0008-5472.can-11-0013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrain NeoplasmsChildChromosome MappingFamily HealthFemaleGenetic HeterogeneityGenetic Predisposition to DiseaseGenome, HumanGenome-Wide Association StudyGenotypeGliomaHumansLinkage DisequilibriumLod ScoreMaleMiddle AgedPedigreePolymorphism, Single NucleotideUnited StatesYoung Adult
2007
GLIOGENE—an International Consortium to Understand Familial Glioma
Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE—an International Consortium to Understand Familial Glioma. Cancer Epidemiology Biomarkers & Prevention 2007, 16: 1730-1734. PMID: 17855690, DOI: 10.1158/1055-9965.epi-07-0081.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCohort StudiesEuropeGenetic LinkageGenetic MarkersGenetic Predisposition to DiseaseGenome, HumanGliomaHumansInternational AgenciesIsraelNorth AmericaPedigreePolymorphism, Single NucleotideConceptsNew genomic regionsGlioma familiesSingle nucleotide polymorphism (SNP) approachFamilial gliomaGenomic regionsGlioma genesLinkage analysisGenesPolymorphism approachLinkage studiesInternational ConsortiumNorth AmericaFamilyLi-Fraumeni syndromeFamilial aggregationDevastating cancerLociTurcot syndromeGenetic syndromesConsortiumGliomagenesisInherited factorsType 1GliomasTuberous sclerosis