2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2018
E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders
DeVito E, Buta E, Sofuoglu M. E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders. Addictive Behaviors 2018, 92: 53-57. PMID: 30583091, PMCID: PMC6699503, DOI: 10.1016/j.addbeh.2018.12.013.Peer-Reviewed Original ResearchConceptsElectronic cigarettesNicotine levelsTobacco useTake-home trialOne monthNicotine electronic cigarettesHigh nicotine dependenceComorbid psychiatric disordersSmoking-related outcomesCombustible cigarette useNicotine e-liquidCombustible tobacco useBaseline characteristicsCessation aidCigarette smokersSmoking characteristicsNicotine doseWorse outcomesEC efficacyNicotine dependenceSmokersPsychiatric disordersCigarette useCombustible cigarettesSmoking
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMenCannabis Abstinence During Treatment and One-Year Follow-Up: Relationship to Neural Activity in Men
Kober H, DeVito EE, DeLeone CM, Carroll KM, Potenza MN. Cannabis Abstinence During Treatment and One-Year Follow-Up: Relationship to Neural Activity in Men. Neuropsychopharmacology 2014, 39: 2288-2298. PMID: 24705568, PMCID: PMC4138744, DOI: 10.1038/npp.2014.82.Peer-Reviewed Original ResearchConceptsCannabis-dependent groupHealthy comparison groupNeural activityCognitive controlLess cannabisDorsal anterior cingulate cortexCognitive control taskCognitive behavioral therapyTreatment development effortsCannabis-dependent individualsAnterior cingulate cortexAddiction-related processesFMRI taskSubstance use disordersCannabis abstinenceCingulate cortexVentral striatumCannabis dependenceCannabis useContingency managementLess abstinenceAbstinenceHealthy individualsCannabisGreater activityToward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes
Carroll KM, Kiluk BD, Nich C, DeVito EE, Decker S, LaPaglia D, Duffey D, Babuscio TA, Ball SA. Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes. Drug And Alcohol Dependence 2014, 137: 3-19. PMID: 24556275, PMCID: PMC4042667, DOI: 10.1016/j.drugalcdep.2014.01.012.Peer-Reviewed Original Research
2013
Gender differences in a clinical trial for prescription opioid dependence
McHugh RK, DeVito EE, Dodd D, Carroll KM, Potter JS, Greenfield SF, Connery HS, Weiss RD. Gender differences in a clinical trial for prescription opioid dependence. Journal Of Substance Use And Addiction Treatment 2013, 45: 38-43. PMID: 23313145, PMCID: PMC3626739, DOI: 10.1016/j.jsat.2012.12.007.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOpioid dependenceClinical trialsOpioid dependence severityPrescription drug dependenceLarge clinical trialsOpioid use outcomesGreater functional impairmentRoute of administrationSubstance use disordersGender differencesGreater psychiatric severityClinical characteristicsMedication doseStudy treatmentOpioid outcomesFunctional impairmentTreatment outcomesPre-treatment differencesPsychiatric severityTreatment retentionUse disordersLegitimate prescriptionDrug dependenceOpioids