2018
Structural correlates of cognitive impairment in normal pressure hydrocephalus
Peterson KA, Mole TB, Keong NCH, DeVito EE, Savulich G, Pickard JD, Sahakian BJ. Structural correlates of cognitive impairment in normal pressure hydrocephalus. Acta Neurologica Scandinavica 2018, 139: 305-312. PMID: 30428124, PMCID: PMC6492129, DOI: 10.1111/ane.13052.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusNPH patientsNeuropsychiatric symptomsPressure hydrocephalusNeuropsychiatric measuresNeuropsychological testsStructure volumesStriatal volume lossDeep gray matter structuresMeasures of apathySubcortical deep gray matter structuresT1-weighted magnetic resonanceGray matter structuresNAcc volumeSmaller caudateNeuropsychiatric changesHealthy controlsPathological basisNPH groupCaudate nucleusNucleus accumbensCaudate volumePatientsSubcortical regionsCognitive impairment
2017
Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus
Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, DeVito EE, Housden CR, Sahakian BJ, Pickard JD. Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus. PLOS ONE 2017, 12: e0181624. PMID: 28817574, PMCID: PMC5560677, DOI: 10.1371/journal.pone.0181624.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusWhite matter injuryDiffusion tensor imagingPressure hydrocephalusInternal capsulePosterior limbDTI measuresPatterns of injuryDifferent white matter tractsNon-invasive biomarkersWhite matter tractsInferior longitudinal fasciculusClinical outcomesInjury patternsNPH patientsEarly diagnosisLongitudinal fasciculusAxial diffusivityTensor imagingInjuryHydrocephalusPatientsImaging profileIndividual tractsTract