2024
The association between salivary oxytocin, age, and puberty in children with and without OCD
Mora-Jensen A, Clemmensen L, Grønberg M, Lebowitz E, Quintana D, Jørgensen N, Larsen C, Bak L, Christensen G, Pretzmann L, Uhre V, Christensen S, Uhre C, Korsbjerg N, Thoustrup C, Hagstrøm J, Ritter M, Plessen K, Pagsberg A, Lønfeldt N. The association between salivary oxytocin, age, and puberty in children with and without OCD. Scientific Reports 2024, 14: 28693. PMID: 39562644, PMCID: PMC11576962, DOI: 10.1038/s41598-024-80194-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOxytocin concentrationsPediatric obsessive-compulsive disorderSalivary oxytocin concentrationsVisual inspection of plotsOxytocin systemPsychiatric disordersSalivary oxytocinEnzyme-linked immunosorbent assayBehavioral changesPubertal stageAdolescentsModerate supportOxytocinInconsistent resultsPost-hocDisordersChildrenPost hoc testSystem activityCovariates ageParentsAssociationImmunosorbent assayHypothesis
2023
Randomized trial comparing standard versus light intensity parent training for anxious youth
Storch E, Guzick A, Ayton D, Palo A, Kook M, Candelari A, Maye C, McNeel M, Trent E, Garcia J, Onyeka O, Rast C, Shimshoni Y, Lebowitz E, Goodman W. Randomized trial comparing standard versus light intensity parent training for anxious youth. Behaviour Research And Therapy 2023, 173: 104451. PMID: 38154287, DOI: 10.1016/j.brat.2023.104451.Peer-Reviewed Original ResearchObsessive-compulsive disorderAnxiety severityAnxious Childhood EmotionsParent-reported anxietyPost-treatment anxietyTreatment conditionsAnxious youthChildhood EmotionsParent trainingFamily accommodationSupportive parentingAnxiety treatmentDiverse sampleAnxietyOne monthSignificant anxietyYouthChange scoresIndependent evaluatorsFunctional impairmentParentsFurther supportSessionsTotal change scoresEmotions
2021
An Initial Study of Symptom Accommodation in Adults with Depression
Leonard R, Guastello A, Cooke D, Storch E, Lebowitz E, Riemann B. An Initial Study of Symptom Accommodation in Adults with Depression. International Journal Of Cognitive Therapy 2021, 14: 537-551. DOI: 10.1007/s41811-020-00097-0.Peer-Reviewed Original ResearchSymptom accommodationObsessive-compulsive disorderAnger outburstsDepression severitySelf-report measuresResidential treatment programGood internal consistencyAnxiety sensitivitySocial anxietyExploratory factor analysisAnxiety disordersAccommodation behaviorSix-item scaleFrequency subscaleGreater depression severitySymptom courseTreatment programInternal consistencyFactor analysisMood disordersSignificant predictorsAnxietyDepressionTotal scoreSubscales
2020
Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study
Lønfeldt NN, Strandberg-Larsen K, Verhulst FC, Plessen KJ, Lebowitz ER. Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study. Journal Of Affective Disorders 2020, 274: 112-117. PMID: 32469793, DOI: 10.1016/j.jad.2020.04.067.Peer-Reviewed Original ResearchConceptsChildhood emotional disordersSynthetic oxytocinNationwide register-based cohort studyDanish Medical Birth RegisterRegister-based cohort studyDanish population-based studyEmotional disordersSelective serotonin reuptake inhibitorsMedical Birth RegisterSerotonin reuptake inhibitorsPopulation-based studyUse of oxytocinRevision of guidelinesCrude Cox modelPrescription RegistryTraumatic Stress DisorderCohort studyLabor inductionReuptake inhibitorsDanish patientsSmoking statusObsessive-compulsive disorderBirth RegisterMaternal historyCox model
2019
Family accommodation in psychopathology: A synthesized review
Shimshoni Y, Shrinivasa B, Cherian AV, Lebowitz ER. Family accommodation in psychopathology: A synthesized review. Indian Journal Of Psychiatry 2019, 61: s93-s103. PMID: 30745682, PMCID: PMC6343404, DOI: 10.4103/psychiatry.indianjpsychiatry_530_18.Peer-Reviewed Original ResearchCaregiver burdenSymptom severityFamily accommodationPoor treatment outcomesEfficacy of treatmentGreater symptom severityPosttraumatic stress disorderEnglish language papersObsessive-compulsive disorderFunctional impairmentTic disordersTreatment outcomesPsychiatric disordersElectronic databasesStress disorderDisordersLanguage papersNumber of studiesFamily membersPsychopathologySeverityAutism spectrum disorderRecent findingsSpectrum disorderTreatment
2018
The SPACE program, a parent-based treatment for childhood and adolescent OCD: The case of Jasmine.
Lebowitz ER, Shimshoni Y. The SPACE program, a parent-based treatment for childhood and adolescent OCD: The case of Jasmine. Bulletin Of The Menninger Clinic 2018, 82: 266-287. PMID: 30589579, DOI: 10.1521/bumc.2018.82.4.266.Peer-Reviewed Original ResearchConceptsParent-based treatmentCurrent evidence-based treatmentsCognitive behavioral therapyObsessive-compulsive disorderEvidence-based treatmentsChild avoidFamily accommodationResponse preventionLack of motivationSupportive responsesAdolescent OCDOwn behaviorChildren's symptomsPsychopharmacological treatmentYouthDisordersOCDAdolescentsDistressMotivationCase descriptionTheoretical backgroundParentsSymptomsChildrenSymptom Insight in Pediatric Obsessive-Compulsive Disorder: Outcomes of an International Aggregated Cross-Sectional Sample
Selles RR, Højgaard DRMA, Ivarsson T, Thomsen PH, McBride N, Storch EA, Geller D, Wilhelm S, Farrell LJ, Waters AM, Mathieu S, Lebowitz E, Elgie M, Soreni N, Stewart SE. Symptom Insight in Pediatric Obsessive-Compulsive Disorder: Outcomes of an International Aggregated Cross-Sectional Sample. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 615-619.e5. PMID: 30071984, PMCID: PMC7176075, DOI: 10.1016/j.jaac.2018.04.012.Peer-Reviewed Original Research
2017
Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study
Taylor JH, Lebowitz ER, Jakubovski E, Coughlin CG, Silverman WK, Bloch MH. Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study. Journal Of Clinical Child & Adolescent Psychology 2017, 47: 266-281. PMID: 28956620, PMCID: PMC6191182, DOI: 10.1080/15374416.2017.1371028.Peer-Reviewed Original ResearchConceptsChild/Adolescent Anxiety Multimodal StudyCognitive behavioral therapyModerators of outcomeSevere anxietyCombination of CBTIndependent evaluator ratingsMultimodal studyParent-rated anxietySeparation anxiety disorderMain effect findingsObsessive-compulsive disorderAnxious youthSocial anxietyChild anxietyBehavioral therapyAnxiety severityPill placeboAnxiety disordersEvaluators' ratingsAnxietyModeratorSocioeconomic statusLow socioeconomic statusYouthEffect findingsFamily‐based Conceptualization and Treatment of Obsessive‐Compulsive Related Disorders
Lebowitz E, Golt J. Family‐based Conceptualization and Treatment of Obsessive‐Compulsive Related Disorders. 2017, 1193-1207. DOI: 10.1002/9781118890233.ch66.Peer-Reviewed Original ResearchObsessive-compulsive related disordersCognitive behavioral therapyFamily accommodationAnxious Childhood EmotionsParent-based interventionsObsessive-compulsive disorderClinical case examplesChildhood EmotionsSupportive parentingAccommodation reductionFamily factorsRelated disordersGreater impairmentPoor treatment outcomesMore severe symptomsSuccessful interventionsCase exampleDisordersTreatment outcomesEmotionsParentingInterventionAnxietyStrong emphasisConceptualization
2015
Family accommodation in obsessive-compulsive and anxiety disorders: a five-year update
Lebowitz ER, Panza KE, Bloch MH. Family accommodation in obsessive-compulsive and anxiety disorders: a five-year update. Expert Review Of Neurotherapeutics 2015, 16: 45-53. PMID: 26613396, PMCID: PMC4895189, DOI: 10.1586/14737175.2016.1126181.Peer-Reviewed Original ResearchConceptsFamily accommodationObsessive-compulsive disorderAnxiety disordersNeurobiological underpinningsSevere psychopathologySynthesis of findingsPsychiatric disordersDisordersPsychopathologyMain findingsDistressAccommodationFindingsUnderpinningsEnglish language papersFive-Year UpdatePsycINFOTherapeutic goalsIndividualsLanguage papersResearchTreatment of Extreme Family Accommodation in a Youth with Obsessive-Compulsive Disorder
Lebowitz E. Treatment of Extreme Family Accommodation in a Youth with Obsessive-Compulsive Disorder. 2015, 321-335. DOI: 10.1007/978-3-319-17139-5_22.Peer-Reviewed Original ResearchObsessive-compulsive disorderFamily accommodationPediatric obsessive-compulsive disorderAnxious Childhood EmotionsParent-based treatmentParent-based interventionsObsessive-compulsive symptomsSevere obsessive-compulsive disorderChildhood EmotionsSupportive parentingParent behaviorGreater symptom severityAnxiety disordersCompulsive disorderYouth responsesIllustrative case examplesSymptom severityYouthAngerForceful attemptsParentsCase exampleDistressDisordersEmotions
2014
Clinical and Family Correlates of Coercive–Disruptive Behavior in Children and Adolescents with Obsessive–Compulsive Disorder
Lebowitz E, Storch E, MacLeod J, Leckman J. Clinical and Family Correlates of Coercive–Disruptive Behavior in Children and Adolescents with Obsessive–Compulsive Disorder. Journal Of Child And Family Studies 2014, 24: 2589-2597. DOI: 10.1007/s10826-014-0061-y.Peer-Reviewed Original ResearchObsessive-compulsive disorderFamily accommodationFamily correlatesDisruptive behaviorPediatric obsessive-compulsive disorderFamily styleTreatment-seeking youthFamily-level variablesOCD symptom severityChild-level variablesSymptom accommodationAttacks of rageMediational modelParental distressOCD symptomsHierarchical regressionParticular symptom dimensionsOCD severityCompulsive disorderSymptom dimensionsReport ScaleSymptom severityCOMPARING FAMILY ACCOMMODATION IN PEDIATRIC OBSESSIVE‐COMPULSIVE DISORDER, ANXIETY DISORDERS, AND NONANXIOUS CHILDREN
Lebowitz ER, Scharfstein LA, Jones J. COMPARING FAMILY ACCOMMODATION IN PEDIATRIC OBSESSIVE‐COMPULSIVE DISORDER, ANXIETY DISORDERS, AND NONANXIOUS CHILDREN. Depression And Anxiety 2014, 31: 1018-1025. PMID: 24677578, DOI: 10.1002/da.22251.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnxiety disordersChildhood obsessive-compulsive disorderHealthy controlsNA groupSymptom severityPoor treatment outcomesFamily accommodationSeverity of anxietyPediatric obsessive-compulsive disorderMothers of childrenAssessment of childrenTreatment outcomesClinical careGeneral populationClinical groupsComparison groupLower functioningDisordersMeasures of accommodationSeverityChildrenChild avoidGreater distressEmotional disorders
2012
FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS
Lebowitz ER, Woolston J, Bar‐Haim Y, Calvocoressi L, Dauser C, Warnick E, Scahill L, Chakir AR, Shechner T, Hermes H, Vitulano LA, King RA, Leckman JF. FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS. Depression And Anxiety 2012, 30: 47-54. PMID: 22965863, PMCID: PMC3932435, DOI: 10.1002/da.21998.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersFamily Accommodation ScaleFamily accommodationAnxiety disordersMeasures of anxietyFamilies of childrenObsessive-compulsive disorderGood internal consistencyTwo-factor solutionAnxious childrenPediatric anxietyAccommodation ScaleSeparation anxietyGreater symptom severityAnxiety symptomsCompulsive disorderDivergent validityFamily routinesAnxietyDiagnostic InterviewPoor treatment outcomesInternal consistencySymptom severityMost parentsFactor analysisTourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder
Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, the Tourette Syndrome Study Group, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 2012, 21: 451-457. PMID: 22543961, PMCID: PMC3722559, DOI: 10.1007/s00787-012-0278-5.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderComorbid tic disordersObsessive-compulsive disorderSeverity of ticsChronic tic disorderTic disordersPsychosocial stressDeficit hyperactivity disorderGlobal functioningComorbid diagnosesHyperactivity disorderMore severe ticsComorbid attention deficit hyperactivity disorderDiagnosis of OCDComorbid obsessive-compulsive disorderAdditional comorbid diagnosesSymptoms of anxietyHigh psychosocial stressMore internalizing disordersGreater psychosocial stressSevere ticsOppositional defiant disorderSevere subtypeTic severityTourette syndromePoor insight in pediatric obsessive compulsive disorder: Developmental considerations, treatment implications, and potential strategies for improving insight
Adelman C, Lebowitz E. Poor insight in pediatric obsessive compulsive disorder: Developmental considerations, treatment implications, and potential strategies for improving insight. Journal Of Obsessive-Compulsive And Related Disorders 2012, 1: 119-124. DOI: 10.1016/j.jocrd.2012.02.003.Peer-Reviewed Original ResearchPediatric obsessive-compulsive disorderObsessive-compulsive disorderPoor insightCompulsive disorderTreatment implicationsCognitive behavioral therapyBehavioral therapyGreater symptom severityObsessive thoughtsOCD symptomsDevelopmental considerationsChildren's insightGreater functional impairmentDevelopmental contextPoor treatment responseSymptom severityDegree of insightEmpirical researchFunctional impairmentDisordersImplicationsTreatment responseImpairmentThoughtChildren
2011
Coercive and Disruptive Behaviors in Pediatric Obsessive Compulsive Disorder: A Qualitative Analysis
Lebowitz ER, Vitulano LA, Omer H. Coercive and Disruptive Behaviors in Pediatric Obsessive Compulsive Disorder: A Qualitative Analysis. Psychiatry 2011, 74: 362-371. PMID: 22168296, DOI: 10.1521/psyc.2011.74.4.362.Peer-Reviewed Original ResearchConceptsFamily accommodationDisruptive behaviorCoercive behaviorPediatric obsessive-compulsive disorderObsessive-compulsive symptom dimensionsObsessive-compulsive childObsessive-compulsive disorderLevel of impairmentChild OCDCompulsive disorderSymptom dimensionsOCDInterview pointsClinical experience pointsSymptom severityTheory methodologyQualitative explorationAdolescentsChildrenEmergent themesSuch situationsParentsExperience pointsTreatment outcomesQualitative analysis