2015
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation
Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1607-1612. PMID: 25605929, PMCID: PMC4321293, DOI: 10.1073/pnas.1421419112.Peer-Reviewed Original ResearchConceptsSummer active stateNervous tissue functionPalmitate-induced uncouplingDifferential transcriptomicsMolecular mechanismsHibernating mammalsBrown adipose tissueBody temperatureProtein 1Ground squirrelsBiochemical analysisTorpid squirrelsHibernation seasonTissue functionActive stateUCP1 expressionHigh expressionHibernationPharmacologic analysisThermogenic proteinsAdipose tissueBrain temperatureLow body temperatureNervous systemPhysiologic phenotype
2010
Molecular basis of infrared detection by snakes
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D. Molecular basis of infrared detection by snakes. Nature 2010, 464: 1006-1011. PMID: 20228791, PMCID: PMC2855400, DOI: 10.1038/nature08943.Peer-Reviewed Original ResearchConceptsTranscriptional profiling approachVertebrate nervous systemTransient receptor potential channelsPit organsMolecular basisEvolutionary tuningUnique sensory systemPhotochemical transductionIon channelsProfiling approachSnakesPotential channelsNerve fibersPrimary transducerSensory systemsPredatorsOrgansPreySensory nerve fibersTransductionTRPA1 channelsNervous systemTransducesThermosensorsInfrared receptors