2017
Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds
Vora A, Taank V, Dutta SM, Anderson JF, Fish D, Sonenshine DE, Catravas JD, Sultana H, Neelakanta G. Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds. Scientific Reports 2017, 7: 44593. PMID: 28300174, PMCID: PMC5353578, DOI: 10.1038/srep44593.Peer-Reviewed Original ResearchConceptsDifferent immune backgroundsImmune backgroundImmunodeficient animalsImmunocompetent animalsAge-matched miceAntibody-blocking assaysIxodes scapularis ticksFibrinogenolytic activityD-dimerAnti-hemostatic factorsImmune defenseTick feedingScapularis ticksReduced levelsBlood feedingEngorgement weightLC-MS/MSFibrinogenolysisNovel roleAnimalsPCR analysisTicksFeeding
2014
Long-term in vitro cultivation of Borrelia miyamotoi
Margos G, Stockmeier S, Hizo-Teufel C, Hepner S, Fish D, Dautel H, Sing A, Dzaferovic E, Rieger M, Jungnick S, Binder K, Straubinger RK, Fingerle V. Long-term in vitro cultivation of Borrelia miyamotoi. Ticks And Tick-borne Diseases 2014, 6: 181-184. PMID: 25561082, DOI: 10.1016/j.ttbdis.2014.12.001.Peer-Reviewed Original ResearchBlood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice
Krause PJ, Hendrickson JE, Steeves TK, Fish D. Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion 2014, 55: 593-597. PMID: 25251880, DOI: 10.1111/trf.12879.Peer-Reviewed Original ResearchConceptsTransfusion transmissionRed blood cellsBorrelia miyamotoiBlood transfusion transmissionMurine transfusion modelFever spirochete Borrelia miyamotoiSpirochete clearanceRecipient bloodC57BL/6 miceMouse recipientsTransfusion modelMouse modelTransfusionMurine bloodHuman infectionsWet mountLyme diseaseStudy designBlood cellsMiceMiyamotoiSpirochetemiaFever spirochetesBloodBodied ticks
1998
Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks
Hodzic E, Fish D, Maretzki C, De Silva A, Feng S, Barthold S. Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks. Journal Of Clinical Microbiology 1998, 36: 3574-3578. PMID: 9817875, PMCID: PMC105242, DOI: 10.1128/jcm.36.12.3574-3578.1998.Peer-Reviewed Original ResearchConceptsInfected miceHuman granulocytic ehrlichiosisHGE agentIxodes scapularis ticksGranulocytic ehrlichiosisUninfected larval ticksAcquisition of infectionScapularis ticksMedian infectious doseLarval ticksNymphal ticksTick-borne transmissionC3H miceImmunodeficient miceInfectious doseMiceHuman isolatesInfectionOnset of feedingBloodEhrlichiosisPresent studyMammalian hostsCompetitive PCRTicksGranulocytic Ehrlichiosis in the Laboratory Mouse
Hodzic E, IJdo J, Feng S, Katavolos P, Sun W, Maretzki C, Fish D, Fikrig E, Telford S, Barthold S. Granulocytic Ehrlichiosis in the Laboratory Mouse. The Journal Of Infectious Diseases 1998, 177: 737-745. PMID: 9498456, DOI: 10.1086/514236.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisMouse passageGranulocytic ehrlichiosisHL-60 cell culturesPeripheral bloodC3H miceLate infectionEarly infectionCell culturesDay 17Day 5Blood smearsNormal valuesDay 24Polymerase chain reaction amplificationHGE agentChain reaction amplificationSpleen smearsMiceInfectionInfectivity assaysBloodLaboratory miceSmearsReaction amplification