2009
Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice
Vesely DL, Fish D, Shlomchik MJ, Kaplan DH, Bockenstedt LK. Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice. Infection And Immunity 2009, 77: 1881-1887. PMID: 19273564, PMCID: PMC2681756, DOI: 10.1128/iai.00030-09.Peer-Reviewed Original ResearchConceptsTh1 responseTick salivaLangerhans cell subsetsLC-deficient miceSkin dendritic cellsTh1 immune responseTh cell polarizationTh cell responsesRegional lymph nodesT cell responsesTick feedingSecondary lymphoid organsGamma interferon productionSpleens of miceWild-type miceIxodes scapularis ticksT helperDendritic cellsLymph nodesLN cellsCell subsetsImmunomodulatory effectsLymphoid organsTh2 cellsImmune response
2000
Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL‐2 and IFNγ production and promotes an IL‐4 response in C3H/HeJ mice
Zeidner N, Dolan M, Massung R, Piesman J, Fish D. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL‐2 and IFNγ production and promotes an IL‐4 response in C3H/HeJ mice. Parasite Immunology 2000, 22: 581-588. PMID: 11116438, DOI: 10.1046/j.1365-3024.2000.00339.x.Peer-Reviewed Original ResearchConceptsIL-4 productionIL-2Human granulocytic ehrlichiosisT cellsB. burgdorferiGranulocytic ehrlichiosisC3H/HeJ miceSplenic IL-4Systemic IL-2Th2 cytokine responsesIL-4 responsesIFN-gamma productionSplenic T cellsIFN-gamma responsesTick infestationHuman granulocytic ehrlichiosis (HGE) agentBorrelia burgdorferi transmissionIFNγ productionCytokine responsesIL-4HeJ miceGamma productionB cellsCoinfectionDay 10
1998
Granulocytic Ehrlichiosis in the Laboratory Mouse
Hodzic E, IJdo J, Feng S, Katavolos P, Sun W, Maretzki C, Fish D, Fikrig E, Telford S, Barthold S. Granulocytic Ehrlichiosis in the Laboratory Mouse. The Journal Of Infectious Diseases 1998, 177: 737-745. PMID: 9498456, DOI: 10.1086/514236.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisMouse passageGranulocytic ehrlichiosisHL-60 cell culturesPeripheral bloodC3H miceLate infectionEarly infectionCell culturesDay 17Day 5Blood smearsNormal valuesDay 24Polymerase chain reaction amplificationHGE agentChain reaction amplificationSpleen smearsMiceInfectionInfectivity assaysBloodLaboratory miceSmearsReaction amplification