1989
Insulin resistance in uremia: An in vivo and in vitro study
Stein P, Hunt W, Johnson C, DeFronzo R, Smith J. Insulin resistance in uremia: An in vivo and in vitro study. Metabolism 1989, 38: 562-567. PMID: 2657327, DOI: 10.1016/0026-0495(89)90217-5.Peer-Reviewed Original ResearchConceptsUremic ratsAbility of insulinInsulin resistanceSoleus muscleTotal body glucose disposalEuglycemic insulin clamp techniqueInsulin clamp techniqueUremic rat modelHepatic glucose productionPair-fed controlsChronic uremiaGlucose disposalRat modelGlucose metabolismClamp techniqueGlucose productionMetabolic defectsInsulinRatsUremiaGlycogen synthesisGlucose oxidationMuscleVivoOxidative pathway
1985
Is glucose intolerance harmful for the uremic patient?
DeFronzo R, Smith J. Is glucose intolerance harmful for the uremic patient? Kidney International Supplement 1985, 17: s88-97. PMID: 3912590.Peer-Reviewed Original ResearchImproved Insulin Sensitivity in Patients with Type I Diabetes Mellitus After CSII
Simonson D, Tamborlane W, Sherwin R, Smith J, DeFronzo R, Group T. Improved Insulin Sensitivity in Patients with Type I Diabetes Mellitus After CSII. Diabetes 1985, 34: 80-86. PMID: 3894130, DOI: 10.2337/diab.34.3.s80.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionGlucose metabolismDiabetic patientsControl subjectsTissue sensitivityAge-matched control subjectsEuglycemic insulin clamp techniqueInsulin-mediated glucose utilizationInsulin clamp techniqueSubcutaneous insulin infusionPlasma glucose concentrationHepatic glucose productionInsulin-stimulated glucose uptakeType IIDDM patientsGlycemic controlInsulin infusionInsulin sensitivityImpaired responseInsulin administrationPeripheral tissuesPatientsClamp techniqueGlucose utilizationMetabolic correctionEffect of insulin on the distribution and disposition of glucose in man.
Ferrannini E, Smith J, Cobelli C, Toffolo G, Pilo A, DeFronzo R. Effect of insulin on the distribution and disposition of glucose in man. Journal Of Clinical Investigation 1985, 76: 357-364. PMID: 3894421, PMCID: PMC423783, DOI: 10.1172/jci111969.Peer-Reviewed Original Research