1998
Measuring human brain GABA in vivo
Petroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidGABA concentrationSeizure controlDaily doseRelease of GABACerebrospinal fluid GABA concentrationsGABA synthesisImproved seizure controlComplex partial seizuresPoor seizure controlTraditional antiepileptic drugsSingle oral doseEffects of vigabatrinElevated CSFImportant protective mechanismPartial seizuresOral doseSeizure disorderAntiepileptic drugsNonvesicular releaseSeizure activityGABA levelsTransporter reversalVigabatrin
1996
Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy
Petroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.Peer-Reviewed Original ResearchConceptsBrain GABA contentImproved seizure controlBrain GABA levelsSeizure controlVigabatrin treatmentGABA levelsDaily doseAntiepileptic drugsOccipital lobeBrain gamma-aminobutyric acid (GABA) concentrationsGABA concentrationHuman brain GABA levelsGABA contentGamma-aminobutyric acid concentrationΓ-aminobutyric acid (GABA) levelsComplex partial seizuresNovel antiepileptic drugBrain GABA concentrationsSeizure frequencyPartial seizuresVigabatrin therapySustained elevationHuman occipital lobeGABA synthesisAcid levels
1993
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman D, Petroff O, Behar K, Mattson R. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5662-5666. PMID: 8516315, PMCID: PMC46781, DOI: 10.1073/pnas.90.12.5662.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA concentrationGABA-transaminase inhibitor vigabatrinBrain gamma-aminobutyric acidDose-dependent elevationSeizure suppressionOccipital lobeHigh doseNonepileptic subjectsHuman volunteersHuman cortexVigabatrinDrug vigabatrinBrainPatientsHuman brainVolunteersCortexDose
1992
Localized 1H NMR spectra of glutamate in the human brain
Rothman D, Hanstock C, Petroff O, Novotny E, Prichard J, Shulman R. Localized 1H NMR spectra of glutamate in the human brain. Magnetic Resonance In Medicine 1992, 25: 94-106. PMID: 1350656, DOI: 10.1002/mrm.1910250110.Peer-Reviewed Original Research