2000
Design of single-layer β-sheets without a hydrophobic core
Koide S, Huang X, Link K, Koide A, Bu Z, Engelman D. Design of single-layer β-sheets without a hydrophobic core. Nature 2000, 403: 456-460. PMID: 10667801, DOI: 10.1038/35000255.Peer-Reviewed Original ResearchConceptsSingle-layer β-sheetΒ-sheetHydrophobic coreΒ-sheet segmentsProtein foldingHydrogen-deuterium exchangeOuter surface protein AΒ-sheet structureChemical denaturationSmall-angle X-rayProtein AFoldingMain thermodynamic driving forceSurface protein ABorrelia burgdorferiNuclear magnetic resonanceThermodynamic driving forceMisfoldingNonpolar moietiesHydrophobic effectSolvent resultsProteinAdjacent unitsDenaturationVariants
1995
Small angle x-ray scattering studies of magnetically oriented lipid bilayers
Hare B, Prestegard J, Engelman D. Small angle x-ray scattering studies of magnetically oriented lipid bilayers. Biophysical Journal 1995, 69: 1891-1896. PMID: 8580332, PMCID: PMC1236422, DOI: 10.1016/s0006-3495(95)80059-7.Peer-Reviewed Original ResearchConceptsNuclear magnetic resonanceLipid bilayersMembrane-associated moleculesBilayer thicknessLipid particlesSmall-angle X-rayX-ray scatteringAngle X-rayNMR dataDLPC vesiclesOrientational parametersX-ray solutionMolar ratioPhospholipid moleculesStructural studiesOrientational energyPhospholipid bilayersAnalogue 3MoleculesBilayersInterparticle spacingX-rayMagnetic resonanceParticlesComplexes
1992
Truncated staphylococcal nuclease is compact but disordered.
Flanagan J, Kataoka M, Shortle D, Engelman D. Truncated staphylococcal nuclease is compact but disordered. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 748-752. PMID: 1731350, PMCID: PMC48316, DOI: 10.1073/pnas.89.2.748.Peer-Reviewed Original ResearchConceptsComplete folding pathwayWild-type levelsCarboxyl-terminal deletionsSecondary structural featuresNative-like conformationPersistent secondary structureProtein foldsCarboxyl terminusFolding pathwaysPolypeptide chainSecondary structureAmino acidsStaphylococcal nucleaseSmall-angle X-rayNuclear magnetic resonanceCircular dichroismPhysiological conditionsNucleasePotent inhibitorDeletionSolvent exclusionMolecules resultsStructural featuresPresence of calciumRibosomes
1972
Molecular Mechanism for the Interaction of Phospholipid with Cholesterol
ROTHMAN J, ENGELMAN D. Molecular Mechanism for the Interaction of Phospholipid with Cholesterol. Nature 1972, 237: 42-44. PMID: 4503742, DOI: 10.1038/newbio237042a0.Peer-Reviewed Original Research